Abstract: A system for mixing powdered materials includes a cannula and an actuator adapted to vibrate the cannula. An optional fluid delivery system is operable to add fluid to the powdered mixture through the cannula. The cannula can be extended into a powder bed and vibrated by the actuator to mix the powder bed. Fluid can be added to the powder bed through the cannula. The systems and methods are suitable for preparing relatively small quantities of candidate mixtures for high-throughput screening. Sample mixtures prepared by the mixing system can be pressed into tablets that are substantially devoid of foreign objects used to mix the samples. The sample mixtures can be subjected to one or more tests, such as an accelerated aging or forced degradation test, to assess one or more characteristics of the sample mixtures.