Patents by Inventor Grant Masaaki SHIBUYA

Grant Masaaki SHIBUYA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 11,13-modified saxitoxins for the treatment of pain
    Patent number: 11834456
    Abstract: Provided herein are compounds, pharmaceutical compositions comprising the compounds, methods of preparing the compounds, and methods of using the compounds and compositions in treating conditions associated with voltage-gated sodium channel function where the compounds are 11,13-modified saxitoxins according to Formula (I): where R4, R4a, R7, R7a, and X2 are as described herein.
    Type: Grant
    Filed: January 26, 2022
    Date of Patent: December 5, 2023
    Assignees: SITEONE THERAPEUTICS, INC., THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: John Mulcahy, Hassan Pajouhesh, George Miljanich, Anton Delwig, Jacob Beckley, Grant Masaaki Shibuya, Justin Du Bois
  • 11,13-MODIFIED SAXITOXINS FOR THE TREATMENT OF PAIN
    Publication number: 20220259218
    Abstract: Provided herein are compounds, pharmaceutical compositions comprising the compounds, methods of preparing the compounds, and methods of using the compounds and compositions in treating conditions associated with voltage-gated sodium channel function where the compounds are 11,13-modified saxitoxins according to Formula (I): where R4, R4a, R7, R7a, and X2 are as described herein.
    Type: Application
    Filed: January 26, 2022
    Publication date: August 18, 2022
    Inventors: John Mulcahy, Hassan Pajouhesh, George Miljanich, Anton Delwig, Jacob Beckley, Grant Masaaki Shibuya, Justin Du Bois
  • 11,13-modified saxitoxins for the treatment of pain
    Patent number: 11279706
    Abstract: Provided herein are compounds, pharmaceutical compositions comprising the compounds, methods of preparing the compounds, and methods of using the compounds and compositions in treating conditions associated with voltage-gated sodium channel function where the compounds are 11,13-modified saxitoxins according to Formula (I): where R1, X1, and X2 are as described herein.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: March 22, 2022
    Assignees: SITEONE THERAPEUTICS, INC., THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: John Mulcahy, Hassan Pajouhesh, George Miljanich, Anton Delwig, Jacob Beckley, Grant Masaaki Shibuya, Justin Du Bois
  • 11,13-modified saxitoxins for the treatment of pain
    Patent number: 11236097
    Abstract: Provided herein are compounds, pharmaceutical compositions comprising the compounds, methods of preparing the compounds, and methods of using the compounds and compositions in treating conditions associated with voltage-gated sodium channel function where the compounds are 11,13-modified saxitoxins according to Formula (I): where R4, R4a, R7, R7a, and X2 are as described herein.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: February 1, 2022
    Assignees: SITEONE THERAPEUTICS, INC., THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: John Mulcahy, Hassan Pajouhesh, George Miljanich, Anton Delwig, Jacob Beckley, Grant Masaaki Shibuya, Justin Du Bois
  • 11,13-MODIFIED SAXITOXINS FOR THE TREATMENT OF PAIN
    Publication number: 20200102318
    Abstract: Provided herein are compounds, pharmaceutical compositions comprising the compounds, methods of preparing the compounds, and methods of using the compounds and compositions in treating conditions associated with voltage-gated sodium channel function where the compounds are 11,13-modified saxitoxins according to Formula (I): where R4, R4a, R7, R7a, and X2 are as described herein.
    Type: Application
    Filed: March 29, 2018
    Publication date: April 2, 2020
    Inventors: John MULCAHY, Hassan PAJOUHESH, George MILJANICH, Anton DELWIG, Jacob BECKLEY, Grant Masaaki SHIBUYA, Justin DU BOIS
  • 11,13-MODIFIED SAXITOXINS FOR THE TREATMENT OF PAIN
    Publication number: 20200102317
    Abstract: Provided herein are compounds, pharmaceutical compositions comprising the compounds, methods of preparing the compounds, and methods of using the compounds and compositions in treating conditions associated with voltage-gated sodium channel function where the compounds are 11,13-modified saxitoxins according to Formula (I): where R1, X1, and X2 are as described herein.
    Type: Application
    Filed: March 29, 2018
    Publication date: April 2, 2020
    Inventors: John MULCAHY, Hassan PAJOUHESH, George MILJANICH, Anton DELWIG, Jacob BECKLEY, Grant Masaaki SHIBUYA, Justin DU BOIS
  • 11,13-modified saxitoxins for the treatment of pain
    Patent number: 10112953
    Abstract: Provided herein are compounds, pharmaceutical compositions comprising the compounds, methods of preparing the compounds, and methods of using the compounds and compositions in treating conditions associated with voltage-gated sodium channel function where the compounds are 11,13-modified saxitoxins according to Formula (I): where R1, X1 and X3 are as described herein.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: October 30, 2018
    Assignees: SITEONE THERAPEUTICS, INC., THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: John Mulcahy, Hassan Pajouhesh, Grant Masaaki Shibuya, Anton Delwig, George Miljanich, Justin Du Bois
  • 11,13-MODIFIED SAXITOXINS FOR THE TREATMENT OF PAIN
    Publication number: 20170233398
    Abstract: Provided herein are compounds, pharmaceutical compositions comprising the compounds, methods of preparing the compounds, and methods of using the compounds and compositions in treating conditions associated with voltage-gated sodium channel function where the compounds are 11,13-modified saxitoxins according to Formula (I): where R1, X1 and X3 are as described herein.
    Type: Application
    Filed: September 30, 2016
    Publication date: August 17, 2017
    Inventors: John MULCAHY, Hassan PAJOUHESH, Grant Masaaki SHIBUYA, Anton DELWIG, George MILJANICH, Justin DU BOIS