Abstract: A subsea friction welding apparatus comprises a chuck for supporting and retaining a weld item prior to welding the weld item to a work-piece, said chuck comprises a plurality of jaws having an internal profile to grip a corresponding profiled surface on the weld item and means for radially expanding the internal profile of the jaws of the chuck, said means actuable by axial insertion of the weld item into the chuck thereby avoiding relative rotation of the chuck and the weld item during insertion of the weld item into the chuck. In operation of the method, a supply of weld items and a weld head are deployed to a subsea location and the weld items are loaded via ROV into the weld head at the subsea location.

Abstract: A subsea friction welding apparatus comprises a chuck for supporting and retaining a weld item prior to welding the weld item to a work-piece, said chuck comprises a plurality of jaws having an internal profile to grip a corresponding profiled surface on the weld item and means for radially expanding the internal profile of the jaws of the chuck, said means actuable by axial insertion of the weld item into the chuck thereby avoiding relative rotation of the chuck and the weld item during insertion of the weld item into the chuck. In operation of the method, a supply of weld items and a weld head are deployed to a subsea location and the weld items are loaded via ROV into the weld head at the subsea location.

Abstract: Compositions for the treatment and/or prevention of IgE-mediated disorders in a mammal by means of RNA interference are provided, together with methods for the use of such compounds. The inventive compositions comprise a binding agent that specifically binds to a target internalizable antigen that is expressed on the surface of a target cell of interest and a genetic construct that is capable of expressing a small interfering nucleic acid molecule (siNA) that suppresses expression of a target gene within the target cell, whereby, after binding to the target antigen, the binding agent and genetic construct are internalized into the cell, and the genetic construct released.