Abstract: This invention relates, e.g., to a synthetic compound, Oxy149, having the structure (Formula I) or a bioactive or pharmaceutical composition comprising Oxy149 and a pharmaceutically acceptable carrier. Methods are also disclosed for using the compound or bioactive or pharmaceutical composition to treat a variety of disorders, including e.g. bone disorders, obesity, cardiovascular disorders, and neurological disorders. Oxy149 can be delivered either locally or systemically.

Abstract: The invention described herein generally pertains to a variably radiused curvilinear gooseneck nozzle for a welding torch.

Abstract: The invention described herein pertains generally to split goosenecks (synonymously swan necks) having a fixed or non-fixed radius for use with welding guns.

Abstract: Bone targeted compounds and methods are provided. Compounds can include a Bone Targeting Portion (RT), having an affinity for bone; a Bone Active Portion (RA) for interacting with and affecting bone; and a Linking Portion (RL) connecting the Bone Targeting Portion and the Bone Active Portion.

Abstract: Bone targeted compounds and methods are provided. Compounds can include a Bone Targeting Portion (RT), having an affinity for bone; a Bone Active Portion (RA) for interacting with and affecting bone; and a Linking Portion (RL) connecting the Bone Targeting Portion and the Bone Active Portion.

Abstract: An apparatus for searching for expressions that appear on a microform medium, the apparatus comprising a microform imager including a sensor for generating digital microform images of one segment of the microform medium at a time, a display screen; and a processor programmed to, while the microform imager is generating a digital microform image: (i) use the digital microform image generated by the microform imager to drive the display screen, (ii) search the digital microform image presented via the display screen for instances of a search expression and (iii) visually distinguish the located search expressions in the digital microform image presented via the display screen.

Abstract: Bone targeted compounds and methods are provided. Compounds can include a Bone Targeting Portion (RT), having an affinity for bone; a Bone Active Portion (RA) for interacting with and affecting bone; and a Linking Portion (RL) connecting the Bone Targeting Portion and the Bone Active Portion.

Abstract: Bone targeted compounds and methods are provided. Compounds can include a Bone Targeting Portion (RT), having an affinity for bone; a Bone Active Portion (RA) for interacting with and affecting bone; and a Linking Portion (RL) connecting the Bone Targeting Portion and the Bone Active Portion.

Abstract: Bone targeted compounds and methods are provided. Compounds can include a Bone Targeting Portion (RT), having an affinity for bone; a Bone Active Portion (RA) for interacting with and affecting bone; a Linking Portion (RL) connecting the Bone Targeting Portion and the Bone Active Portion. The Bone Active Portion is derived from an estrogenic agent. Compounds can also include a Blocking Group (RP) that reduces or eliminates the estrogenic activity of the Bone Active Portion.

Abstract: The present invention relates to compounds of the formula or pharmaceutically acceptable salts thereof, useful for delivering agents having the capacity to diagnose, treat or prevent bone injury or disease to the bone for interaction therewith.

Abstract: The present invention relates to compounds of the formula or pharmaceutically acceptable salts thereof, useful for delivering agents having the capacity to diagnose, treat or prevent bone injury or disease to the bone for interaction therewith.

Abstract: The present invention relates to compounds of the formula or pharmaceutically acceptable salts thereof, useful for delivering agents having the capacity to diagnose, treat or prevent bone injury or disease to the bone for interaction therewith.

Abstract: The present invention relates to alkylated C-sugars which are new carbohydrate derivatives based on the “C-Sugar” platform. These alkylated C-sugars are converted from hydrophilic, hydrogen-bonded saccaride derivatives and are very stable, highly soluble and relatively low molecular weight structures. These alkylated C-sugars can serve as effective bioconjugates and pharmaceutical carriers. The alkylated C-sugar have the formula wherein n=0, 1, 2, 3, 4, Rx=aryl, alkyl, or halogen-substituted aryl or alkyl, Y=(CH2)mNH2,(CH2)mCO2H,(CH2)mOH,(CH2)mCH, or (CH2)mCl, and m=0, 1, 2 or 3.

Abstract: A wheeled vehicle (200) for carrying a person comprising a frame (218, 220, 222, 250) rotatably supporting two substantially in-line wheels (204, 206), and foot support means (254, 256) for, in use, supporting the feet of a user. The wheels are ring-shaped, and the foot support means are in the form of spaced platform structures coupled to the frame and which extend axially through respective said wheels. In order to allow the foot platforms to extend through the central portion of the ring shaped wheels whilst allowing the wheels to rotate, the wheels are rotatably supported on the frame by a plurality of rollers (210) mounted on the frame and arranged around the wheels to bear on circumferential surfaces thereof (208). A motor (236) may also be included to drive one of the wheels under control of the user who is able to operate a hand held throttle control (239).