Patents by Inventor Grant Wishart

Grant Wishart has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HETEROCYCLIC DERIVATIVES
    Publication number: 20120258957
    Abstract: The present invention relates to a heterocyclic derivative according to formula I wherein the variables are defined as in the specification, or to a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to a pharmaceutical composition comprising said heterocyclic derivatives and to their use in therapy, for instance in the treatment or prevention of disorders or diseases influenced by modulation of orexins, such as sleep disorders.
    Type: Application
    Filed: November 22, 2010
    Publication date: October 11, 2012
    Inventors: Matilda Jane Bingham, Andrew Dunbar, Margaret Jean Laats, Grant Wishart
  • TRICYCLIC HETEROCYCLIC DERIVATIVES
    Publication number: 20120232122
    Abstract: The present invention relates to a tricyclic heterocyclic derivative according to Formula (I), wherein the variables are defined as in the specification, or to a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to pharmaceutical compositions comprising said tricyclic heterocyclic derivatives and to their use in therapy, for instance in the treatment or prevention of serotonin mediated disorders, such as obesity.
    Type: Application
    Filed: March 9, 2010
    Publication date: September 13, 2012
    Inventors: Keneth Davies, Takao Kiyoi, Ashvinkumar Dhirubhai Mistry, Peter Christopher Ray, Mark Reid, Grant Wishart
  • BICYCLIC COMPOUNDS AS INHIBITORS OF DIACYGLYCEROL ACYLTRANSFERASE
    Publication number: 20120022057
    Abstract: The present invention relates to novel heterocyclic compounds as diacylglycerol acyltransferase (“DGAT”) inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventing a cardiovascular disease, a metabolic disorder, obesity or an obesity-related disorder, diabetes, dyslipidemia, a diabetic complication, impaired glucose tolerance or impaired fasting glucose. An illustrative compound of the invention is shown below (I).
    Type: Application
    Filed: March 16, 2010
    Publication date: January 26, 2012
    Applicant: Schering Corporation
    Inventors: Gang Zhou, Grant Wishart, Pauline C. Ting, Robert G. Aslanian, Nicolas Zorn, Jianhua Cao
  • BICYCLIC COMPOUNDS AS INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE
    Publication number: 20110319403
    Abstract: The present invention relates to novel heterocyclic compounds as diacylglycerol acyltransferase (“DGAT”) inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventing a cardiovascular disease, a metabolic disorder, obesity or an obesity-related disorder, diabetes, dyslipidemia, a diabetic complication, impaired glucose tolerance or impaired fasting glucose. An illustrative compound of the invention is shown below: formula (I).
    Type: Application
    Filed: March 16, 2010
    Publication date: December 29, 2011
    Applicant: SCHERING CORPORATION
    Inventors: Gang Zhou, Grant Wishart, Pauline C. Ting, Robert G. Aslanian, Nicolas Zorn, David Won-shik Kim
  • Blockade of voltage dependent sodium channels
    Patent number: 7790761
    Abstract: Compounds of Formula I and pharmaceutically acceptable salts thereof, are capable of blockading voltage-dependent sodium channels and are useful in particular, in treating glaucoma and multiple sclerosis.
    Type: Grant
    Filed: December 21, 2005
    Date of Patent: September 7, 2010
    Assignee: University College London
    Inventors: Giti Garthwaite, David Selwood, Marcel Kling, Grant Wishart
  • TRICYCLIC HETEROCYCLIC DERIVATIVES
    Publication number: 20100210680
    Abstract: The present invention relates to a tricyclic heterocyclic derivative of Formula (I) wherein the variables are as defined in the specification. The present invention further relates to pharmaceutical compositions comprising these compounds and to their use in therapy, in particular for the treatment of serotonin-mediated disorders such as obesity, schizophrenia and cognitive dysfunction.
    Type: Application
    Filed: September 15, 2008
    Publication date: August 19, 2010
    Inventors: Simon James Anthony Grove, Takao Kiyoi, Ashvinkumar Dhirubhai Mistry, Peter Christopher Ray, Grant Wishart
  • (Indol-3-yl) heterocycle derivatives as agonists of the cannabinoid CB1 receptor
    Patent number: 7700634
    Abstract: Disclosed herein are indole derivatives of the formula (I) wherein each of the substitutents is given the definition as set forth in the specification and claims. Also disclosed are pharmaceutical compositions containing the indole derivatives and use of the derivatives for the treatment of pain.
    Type: Grant
    Filed: February 28, 2005
    Date of Patent: April 20, 2010
    Assignee: N.V. Organon
    Inventors: Julia Adam-Worrall, Angus John Morrison, Grant Wishart, Takao Kiyoi, Duncan Robert McArthur
  • 1-benzylindole-2-carboxamide derivatives
    Patent number: 7671080
    Abstract: The present invention relates to i-benzylindole-2-carboxamide derivatives of formula I, or a pharmaceutically acceptable salt or solvate thereof. The invention also relates to pharmaceutical compositions comprising said 1-benzylindole-2-carboxamide derivatives and to their use in therapy, particularly for the treatment of obesity or nicotine dependence.
    Type: Grant
    Filed: March 17, 2006
    Date of Patent: March 2, 2010
    Assignee: N.V. Organon
    Inventors: Phillip Martin Cowley, Samuel George Gibson, Grant Wishart
  • 1-Benzylindole-2-Carboxamide Derivatives
    Publication number: 20080280923
    Abstract: The present invention relates to i-benzylindole-2-carboxamide derivatives of formula I, or a pharmaceutically acceptable salt or solvate thereof. The invention also relates to pharmaceutical compositions comprising said 1-benzylindole-2-carboxamide derivatives and to their use in therapy, particularly for the treatment of obesity or nicotine dependence.
    Type: Application
    Filed: March 17, 2006
    Publication date: November 13, 2008
    Applicant: N.V. Organon
    Inventors: Phillip Martin Cowley, Samuel George Gibson, Grant Wishart
  • (Indol-3-yl) heterocycle derivatives as a agonists of the cannabinoid cb1 receptor
    Publication number: 20070142446
    Abstract: Disclosed herein are indole derivatives of the formula (I) wherein each of the substitutents is given the definition as set forth in the specification and claims. Also disclosed are pharmaceutical compositions containing the indole derivatives and use of the derivatives for the treatment of pain.
    Type: Application
    Filed: February 28, 2005
    Publication date: June 21, 2007
    Inventors: Julia Adam-Worrall, Angus Morrison, Grant Wishart, Takao Kiyoi, Duncan McArthur
  • Blockade of voltage dependent sodium channels
    Publication number: 20060100248
    Abstract: Compounds of Formula I and pharmaceutically acceptable salts thereof, are capable of blockading voltage-dependent sodium channels and are useful in particular, in treating glaucoma and multiple sclerosis.
    Type: Application
    Filed: December 21, 2005
    Publication date: May 11, 2006
    Inventors: Giti Garthwaite, David Selwood, Marcel Kling, Grant Wishart
  • Blockade of voltage dependent sodium channels
    Patent number: 7009056
    Abstract: Compounds of formula (I), and pharmaceutically acceptable salts thereof, are capable of blockading voltage-dependent sodium channels and are useful in particular, in treating glaucoma and multiple sclerosis.
    Type: Grant
    Filed: February 5, 2001
    Date of Patent: March 7, 2006
    Assignee: University College London
    Inventors: Giti Garthwaite, David Selwood, Marcel Kling, Grant Wishart
  • Blockade of voltage dependent sodium channels
    Publication number: 20030171403
    Abstract: Compounds of formula (1), and pharmaceutically acceptable salts thereof, are capable of blockading voltage-dependent sodium channels and are useful in particular, in treating glaucoma and multiple sclerosis.
    Type: Application
    Filed: February 25, 2003
    Publication date: September 11, 2003
    Inventors: Giti Garthwaite, David Selwood, Marcel Kling, Grant Wishart