Patents by Inventor Gray D. Shaw

Gray D. Shaw has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for treatment of thrombosis and for prolonging survival of stored platelets
    Patent number: 9266923
    Abstract: Provided herein are methods and compositions, including pharmaceutical compositions, for treating thrombosis, vascular inflammation, and thrombocytopenia. The methods and compositions of the present invention are also useful for extending the useful storage shelf life of platelets.
    Type: Grant
    Filed: June 24, 2011
    Date of Patent: February 23, 2016
    Inventor: Gray D. Shaw
  • Novel Enhanced Selectin Antagonists
    Publication number: 20130136741
    Abstract: Recombinant proteins comprised of multiple selectin binding domains derived from the glycopeptide PSGL-1, in a novel tandem configuration, are disclosed, including their fusions with immunoglobulins and/or other polypeptides. Polynucleotides encoding such proteins, compositions and kits containing such proteins, and methods of using such proteins are also disclosed.
    Type: Application
    Filed: November 28, 2012
    Publication date: May 30, 2013
    Inventor: Gray D. Shaw
  • Compositions and Methods for Treatment of Thrombosis and for Prolonging Survival of Stored Platelets
    Publication number: 20120165258
    Abstract: Provided herein are methods and compositions, including pharmaceutical compositions, for treating thrombosis, vascular inflammation, and thrombocytopenia. The methods and compositions of the present invention are also useful for extending the useful storage shelf life of platelets.
    Type: Application
    Filed: June 24, 2011
    Publication date: June 28, 2012
    Applicant: VASCULOGICS, INC.
    Inventor: Gray D. Shaw
  • PLATELET GLYCOPROTEIN IB ALPHA FUSION POLYPEPTIDES AND METHODS OF USE THEREOF
    Publication number: 20090148427
    Abstract: The present invention provides compositions and methods for treating or preventing vascular-associated disorders.
    Type: Application
    Filed: October 21, 2008
    Publication date: June 11, 2009
    Applicant: Genetics Institute, LLC
    Inventors: Gray D. Shaw, Dianne S. Sako, Ravindra Kumar, Francis Sullivan, Tom McDonagh
  • Selectin ligand interactor cytoplasmic (SLIC-1), a P-selectin glycoprotein ligand (PSGL-1) binding protein
    Patent number: 7405272
    Abstract: The invention provides isolated nucleic acids molecules, designated SLIC-1 nucleic acid molecules, which encode novel P-selectin glycoprotein ligand (PSGL-1) binding molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SLIC-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a SLIC-1 gene has been introduced or disrupted. The invention still further provides isolated SLIC-1 proteins, fusion proteins, antigenic peptides and anti-SLIC-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
    Type: Grant
    Filed: October 12, 2004
    Date of Patent: July 29, 2008
    Assignee: Genetics Institute, L.L.C.
    Inventors: Meike Lorenz, Ron Kriz, Nadine Weich, Gray D. Shaw
  • Platelet glycoprotein Ib? fusion polypeptides and methods of use thereof
    Patent number: 7049128
    Abstract: The present invention provides compositions and methods for treating or preventing vascular-associated disorders.
    Type: Grant
    Filed: March 6, 2003
    Date of Patent: May 23, 2006
    Assignee: Genetics Institute LLC
    Inventors: Gray D. Shaw, Dianne S. Sako, Ravindra Kumar, Francis Sullivan, Tom McDonagh
  • Platlet glycoprotein IB? fusion polypeptides and methods of use thereof
    Patent number: 6991796
    Abstract: The present invention provides compositions and methods for treating or preventing vascular-associated disorders.
    Type: Grant
    Filed: February 6, 2002
    Date of Patent: January 31, 2006
    Assignee: Genetics Institute LLC
    Inventors: Gray D. Shaw, Dianne S. Sako, Ravindra Kumar, Francis Sullivan, Tom McDonagh
  • Methods of identifying compounds which inhibit binding of SLIC-1 to PSGL-1
    Patent number: 6852497
    Abstract: The invention provides isolated nucleic acids molecules, designated SLIC-1 nucleic acid molecules, which encode novel P-selectin glycoprotein ligand (PSGL-1) binding molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SLIC-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a SLIC-1 gene has been introduced or disrupted. The invention still further provides isolated SLIC-1 proteins, fusion proteins, antigenic peptides and anti-SLIC-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
    Type: Grant
    Filed: March 23, 2001
    Date of Patent: February 8, 2005
    Assignee: Genetics Institute, LLC
    Inventors: Meike Lorenz, Ron Kriz, Nadine Weich, Gray D. Shaw
  • Platlet glycoprotein IB alpha fusion polypeptides and methods of use thereof
    Publication number: 20030232047
    Abstract: The present invention provides compositions and methods for treating or preventing vascular-associated disorders.
    Type: Application
    Filed: March 6, 2003
    Publication date: December 18, 2003
    Inventors: Gray D. Shaw, Dianne S. Sako, Ravindra Kumar, Francis Sullivan, Tom McDonagh
  • Platlet glycoprotein Ib alpha fusion polypeptides and methods of use thereof
    Publication number: 20030091576
    Abstract: The present invention provides compositions and methods for treating or preventing vascular-associated disorders.
    Type: Application
    Filed: February 6, 2002
    Publication date: May 15, 2003
    Inventors: Gray D. Shaw, Dianne S. Sako, Ravindra Kumar, Francis Sullivan, Tom McDonagh
  • Novel P-selectin glycoprotein ligand (PSGL-1) binding protein and uses therefor
    Publication number: 20020037840
    Abstract: The invention provides isolated nucleic acids molecules, designated SLIC-1 nucleic acid molecules, which encode novel P-selectin glycoprotein ligand (PSGL-1) binding molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SLIC-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a SLIC-1 gene has been introduced or disrupted. The invention still further provides isolated SLIC-1 proteins, fusion proteins, antigenic peptides and anti-SLIC-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
    Type: Application
    Filed: March 23, 2001
    Publication date: March 28, 2002
    Inventors: Meike Lorenz, Ron Kriz, Nadine Weich, Gray D. Shaw