Abstract: Provided herein are systems for modeling a patients cardiac electrical activity data, including at least one diagnostic catheter for insertion into the heart of the patient and a processing unit. The at least one diagnostic catheter includes at least one recording element to record patient data over multiple cardiac cycles. The patient data includes biopotential data and localization data of the at least one recording element. The processing unit includes a clustering routine that: receives the recorded patient data; segments the recorded patient data by cardiac cycle to produce segmented patient data; groups the segments based on one or more characteristics of the segments to produce segmented data groups; and combines the segmented patient data within each segmented data group to produce one or more composite recordings. The systems create one or more models of cardiac electrical activity of the patient based on the one or more composite recordings.

Abstract: A system for mapping electrical activity of a patient's heart. The system includes a set of electrodes spaced from the heart wall and a set of electrodes in contact with the heart wall. Voltage measurements from the electrodes are used to generate three-dimensional and two-dimensional maps of the electrical activity of the heart.

Abstract: A mapping catheter is positioned in a heart chamber, and active electrode sites are activated to impose an electric field within the chamber. The blood volume and wall motion modulates the electric field, which is detected by passive electrode sites on the preferred catheter. Electrophysiology measurements, as well as geometry measurements, are taken from the passive electrodes and used to display a map of intrinsic heart activity.

Abstract: A method of acquiring and mapping physiological data in a heart chamber includes inserting a catheter into the heart chamber. Physiological data in the heart chamber is acquired with the catheter. The position of the catheter is determined, and the location of the acquired physiological data is determined using the position of the catheter. Information related to the three-dimensional geometry of at least a portion of the heart chamber is received, and a three-dimensional map of the physiological data is created and superimposed on a geometrical representation of the three-dimensional geometry information.

Abstract: A method of delivering ablation therapy in a heart chamber includes inserting a catheter in the heart chamber. Electrophysiological data in the heart chamber is acquired with the catheter. The position of the catheter is determined using an electromagnetic field source external to the heart chamber, and the location of the acquired electrophysiological data is determined using the position of the catheter. The acquired electrophysiological data is integrated with the location of the acquired electrophysiological data. Information related to the three-dimensional geometry of at least a portion of the heart chamber is received. A continuous three-dimensional color-coded map of the electrophysiological data is created and superimposed on a geometrical representation of the three-dimensional geometry information. The map is then utilized to deliver ablation therapy.

Abstract: A method of acquiring and mapping electrophysiological data in a heart chamber includes inserting a catheter having an electrode into the heart chamber. Electrophysiological data in the heart chamber is acquired with the electrode, and the position of the electrode is determined by using an electromagnetic field source external to the heart chamber. A geometrical representation of at least a portion of the heart chamber is created, and a three-dimensional map of the electrophysiological data is created and superimposed on the geometrical representation.

Abstract: A method of acquiring and mapping physiological data in a heart chamber includes inserting a catheter having an electrode into the heart chamber. Physiological data in the heart chamber is acquired with the electrode. The position of the electrode is determined, and the location of the acquired physiological data is determined using the position of the electrode. The acquired physiological data is integrated with the location of the acquired physiological data. Information related to the three-dimensional geometry of at least a portion of the heart chamber is received, and a continuous three-dimensional color-coded map of the physiological data is created and superimposed on a geometrical representation of the three-dimensional geometry information. The map is then utilized to deliver ablation therapy.

Abstract: A method of acquiring and mapping physiological data in a heart chamber includes inserting a catheter having an electrode into the heart chamber. Physiological data in the heart chamber is acquired with the electrode, and the position of the electrode is determined. A geometrical representation of at least a portion of the heart chamber is created, and a three-dimensional map of the physiological data is created and superimposed on the geometrical representation.

Abstract: A method of acquiring and mapping electrophysiological data in a heart chamber includes inserting a catheter into the heart chamber. Electrophysiological data in the heart chamber is acquired with the catheter. The position of the catheter is determined by using an electromagnetic field source external to the heart chamber, and the location of the acquired electrophysiological data is determined using the position of the catheter. Information related to the three-dimensional geometry of at least a portion of the heart chamber is received, and a continuous three-dimensional color-coded map of the electrophysiological data is created and superimposed on a geometrical representation of the three-dimensional geometry information.

Abstract: A method of representing the geometry of at least a portion of a human heart chamber includes positioning a catheter in a heart chamber. The position of the catheter in the heart chamber is determined. The catheter is re-positioned and the position is re-determined a plurality of times to determine the geometry of at least a portion of the heart chamber. A three-dimensional, anatomical representation of at least a portion of the heart chamber is then created.

Abstract: A mapping catheter is positioned in a heart chamber, and active electrode sites are activated to impose an electric field within the chamber. The blood volume and wall motion modulates the electric field, which is detected by passive electrode sites on the preferred catheter. Electrophysiology measurements, as well as geometry measurements, are taken from the passive electrodes and used to display a map of intrinsic heart activity.

Abstract: A computer software program is described that maps the electrical activity of a patient's heart. The software program utilizes inputs from electrodes contained within a heart chamber. Inputs from the electrodes cause the program to calculate the heart chamber volume, and then to determine the position of the electrodes within the heart chamber. The program then utilizes inputs from the electrodes to calculate the three-dimensional volumetric electrical field distribution of said heart chamber. This calculation is accomplished using a spherical harmonic series expression. Finally, the computer program displays the electrical field distribution of the heart chamber.

Abstract: A system for mapping electrical activity of a patient's heart. The system includes a set of electrodes spaced from the heart wall and a set of electrodes in contact with the heart wall. Voltage measurements from the electrodes are used to generate three-dimensional and two-dimensional maps of the electrical activity of the heart.

Abstract: A method and apparatus for processing biological signals on an event basis. An event low pass filter (LPF) is provided which passes variations in event features below an event cut-off value, which is analogous to the time-based cutoff frequency. An event high pass filter (HPF) is provided which passes variations in event features that are above an event-rate cutoff. An event variability detector is provided which determines the variation of a discrete variable from values at prior events. An event discriminator is provided for filtering out contributions of unrelated events that are superimposed on a discrete periodic measurement of interest. In all of these techniques, sampling of a biological signal is performed in coincidence with a biological event which does not occur at a constant frequency. In accordance with another aspect, an algorithm is provided using event-based techniques for discriminating abnormal rhythms from normal sinus rhythm on the basis of atrial rate, ventricular rate, and A-V intervals.