Patents by Inventor Grayson B. Lipford

Grayson B. Lipford has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DOSE SELECTION OF ADJUVANTED SYNTHETIC NANOCARRIERS
    Publication number: 20150328309
    Abstract: Disclosed are synthetic nanocarrier compositions with coupled adjuvant compositions as well as related methods.
    Type: Application
    Filed: May 20, 2015
    Publication date: November 19, 2015
    Applicant: Selecta Biosciences, Inc.
    Inventors: Petr Ilyinskii, Grayson B. Lipford, Charles Zepp
  • TOLEROGENIC SYNTHETIC NANOCARRIERS
    Publication number: 20150328333
    Abstract: This invention relates, at least in part, to compositions comprising synthetic nanocarriers and immunosuppressants that result in immune suppressive effects. Such compositions can further comprise antigen and provide antigen-specific tolerogenic immune responses.
    Type: Application
    Filed: July 27, 2015
    Publication date: November 19, 2015
    Applicant: Selecta Biosciences, Inc.
    Inventors: Christopher Fraser, Grayson B. Lipford, Christopher J. Roy, Roberto A. Maldonado
  • Immune system modulators
    Patent number: 9126996
    Abstract: The present invention relates to a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same; and a method for treating or preventing autoimmunity disease using the same.
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: September 8, 2015
    Assignee: JANUS BIOTHERAPEUTICS, INC.
    Inventors: Grayson B. Lipford, Charles M. Zepp
  • Dose selection of adjuvanted synthetic nanocarriers
    Patent number: 9066978
    Abstract: Disclosed are synthetic nanocarrier compositions with coupled adjuvant compositions as well as related methods.
    Type: Grant
    Filed: May 26, 2011
    Date of Patent: June 30, 2015
    Assignee: Selecta Biosciences, Inc.
    Inventors: Petr Ilyinskii, Grayson B. Lipford, Charles Zepp
  • Immunomodulatory agent-polymeric compounds
    Patent number: 9006254
    Abstract: This invention relates to compositions, and related compounds and methods, of conjugates of immunomodulatory agents and polymers or unit(s) thereof. The conjugates may be contained within synthetic nanocarriers, and the immunomodulatory agents may be released from the synthetic nanocarriers in a pH sensitive manner.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: April 14, 2015
    Assignee: Selecta Biosciences, Inc.
    Inventors: Charles Zepp, Grayson B. Lipford, Yun Gao, Lloyd Johnston, Fen-ni Fu, Mark J. Keegan, Sam Baldwin
  • TARGETED SYNTHETIC NANOCARRIERS WITH PH SENSITIVE RELEASE OF IMMUNOMODULATORY AGENTS
    Publication number: 20140242173
    Abstract: This invention relates to compositions, and related methods, of synthetic nanocarriers that target sites of action in cells, such as antigen presenting cells (APCs), and comprise immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner. Also disclosed are compositions and methods relating to synthetic nanocarriers that encapsulate labile immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner.
    Type: Application
    Filed: May 8, 2014
    Publication date: August 28, 2014
    Applicant: Selecta Biosciences, Inc.
    Inventors: Charles Zepp, Yun Gao, Mark J. Keegan, Sam Baldwin, Fen-ni Fu, Lloyd Johnston, Grayson B. Lipford
  • NOVEL IMIDAZOLE QUINOLINE-BASED IMMUNE SYSTEM MODULATORS
    Publication number: 20140242121
    Abstract: The present invention relates to a compound of Formula I: or an enantiomer, diastereomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same; and a method for treating or preventing autoimmunity disease using the same.
    Type: Application
    Filed: October 3, 2012
    Publication date: August 28, 2014
    Applicant: JANUS BIOTHERAPEUTICS, INC.
    Inventors: Grayson B. Lipford, Charles M. Zepp
  • NOVEL IMMUNE SYSTEM MODULATORS
    Publication number: 20140221646
    Abstract: The present invention relates to a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same; and a method for treating or preventing autoimmunity disease using the same.
    Type: Application
    Filed: February 12, 2014
    Publication date: August 7, 2014
    Applicant: JANUS BIOTHERAPEUTICS, INC.
    Inventors: Grayson B. LIPFORD, Charles M. ZEPP
  • IMMUNOMODULATORY AGENT-POLYMERIC COMPOUNDS
    Publication number: 20140193453
    Abstract: This invention relates to compositions, and related compounds and methods, of conjugates of immunomodulatory agents and polymers or unit(s) thereof. The conjugates may be contained within synthetic nanocarriers, and the immunomodulatory agents may be released from the synthetic nanocarriers in a pH sensitive manner.
    Type: Application
    Filed: December 23, 2013
    Publication date: July 10, 2014
    Applicant: SELECTA BIOSCIENCES, INC.
    Inventors: CHARLES ZEPP, GRAYSON B. LIPFORD, YUN GAO, LLOYD JOHNSTON, FEN-NI FU, MARK J. KEEGAN, SAM BALDWIN
  • IMMUNOSTIMULATORY G, U-CONTAINING OLIGORIBONUCLEOTIDES
    Publication number: 20140135487
    Abstract: Compositions and methods relating to immunostimulatory RNA oligomers are provided. The immunostimulatory RNA molecules are believed to represent natural ligands of one or more Toll-like receptors, including Toll-like receptor 7 (TLR7) and Toll-like receptor 8 (TLR8). The compositions and methods are useful for stimulating immune activation. Methods useful for screening candidate immunostimulatory compounds are also provided.
    Type: Application
    Filed: January 21, 2014
    Publication date: May 15, 2014
    Applicant: COLEY PHARMACEUTICAL GMBH
    Inventors: GRAYSON B. LIPFORD, STEFAN BAUER, HERMANN WAGNER
  • NOVEL IMMUNE SYSTEM MODULATORS
    Publication number: 20140107115
    Abstract: The present invention relates to a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same; and a method for treating or preventing autoimmunity disease using the same.
    Type: Application
    Filed: June 1, 2012
    Publication date: April 17, 2014
    Applicant: Janus Biotherapeutics, Inc.
    Inventors: Grayson B. Lipford, Charles M. Zepp
  • NOVEL IMMUNE SYSTEM MODULATORS
    Publication number: 20140079724
    Abstract: The present invention relates to a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same; and a method for treating or preventing autoimmunity disease using the same.
    Type: Application
    Filed: June 1, 2012
    Publication date: March 20, 2014
    Applicant: Janus Biotherapeutics, Inc.
    Inventors: Grayson B. Lipford, Charles M. Zepp
  • Immunostimulatory G, U-containing oligoribonucleotides
    Patent number: 8658607
    Abstract: Compositions and methods relating to immunostimulatory RNA oligomers are provided. The immunostimulatory RNA molecules are believed to represent natural ligands of one or more Toll-like receptors, including Toll-like receptor 7 (TLR7) and Toll-like receptor 8 (TLR8). The compositions and methods are useful for stimulating immune activation. Methods useful for screening candidate immunostimulatory compounds are also provided.
    Type: Grant
    Filed: March 3, 2006
    Date of Patent: February 25, 2014
    Assignee: Zoetis Belgium
    Inventors: Grayson B. Lipford, Stefan Bauer, Hermann Wagner
  • TARGETED SYNTHETIC NANOCARRIERS WITH PH SENSITIVE RELEASE OF IMMUNOSTIMULATORY AGENTS
    Publication number: 20140030344
    Abstract: This invention relates to compositions, and related methods, of synthetic nanocarriers that target sites of action in cells, such as antigen presenting cells (APCs), and comprise immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner. Also disclosed are compositions and methods relating to synthetic nanocarriers that encapsulate labile immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner.
    Type: Application
    Filed: July 22, 2013
    Publication date: January 30, 2014
    Applicant: Selecta Biosciences, Inc.
    Inventors: Charles Zepp, Yun Gao, Mark J. Keegan, Sam Baldwin, Fen-ni Fu, Lloyd Johnston, Grayson B. Lipford
  • Immunomodulatory agent-polymeric compounds
    Patent number: 8629151
    Abstract: This invention relates to compositions, and related compounds and methods, of conjugates of immunomodulatory agents and polymers or unit(s) thereof. The conjugates may be contained within synthetic nanocarriers, and the immunomodulatory agents may be released from the synthetic nanocarriers in a pH sensitive manner.
    Type: Grant
    Filed: May 26, 2010
    Date of Patent: January 14, 2014
    Assignee: Selecta Biosciences, Inc.
    Inventors: Charles Zepp, Grayson B. Lipford, Yun Gao, Lloyd Johnston, Fen-ni Fu, Mark J. Keegan, Sam Baldwin
  • Immunostimulatory oligonucleotides
    Patent number: 8546550
    Abstract: Compositions that include immunostimulatory nucleic acids are disclosed, along with the use of such compositions to induce immune responses.
    Type: Grant
    Filed: November 16, 2011
    Date of Patent: October 1, 2013
    Assignee: Selecta Biosciences, Inc.
    Inventors: Grayson B. Lipford, Christopher Fraser
  • Immunostimulatory oligoribonucleotides
    Patent number: 8354522
    Abstract: The invention provides immunostimulatory compositions and use of those compounds in the preparation of medicaments for the treatment of disease as well as in vitro uses. In particular, the compositions of the invention include immunostimulatory oligoribonucleotides that incorporate a sequence-dependent immunostimulatory sequence motif. Specific modifications involving phosphate linkages, nucleotide analogs, adducts, and combinations thereof are provided. Compositions of the invention, which optionally can include an antigen, can be used alone or together with other treatments to stimulate or enhance an immune response. Also provided are compositions and methods useful for treating a subject having an infection, a cancer, an allergic condition, asthma, airway remodeling, or immunodeficiency. Immunostimulatory oligoribonucleotides of the invention are believed to stimulate Toll-like receptor 8 (TLR8).
    Type: Grant
    Filed: March 14, 2011
    Date of Patent: January 15, 2013
    Assignees: Coley Pharmaceutical GmbH, Coley Pharmaceutical Group, Inc.
    Inventors: Alexandra Forsbach, Jorg Vollmer, Grayson B. Lipford
  • Immunostimulatory nucleic acids
    Patent number: 8304396
    Abstract: The invention relates to a class of soft or semi-soft CpG immunostimulatory oligonucleotides that are useful for stimulating an immune response.
    Type: Grant
    Filed: October 4, 2006
    Date of Patent: November 6, 2012
    Assignees: Coley Pharmaceutical Group, Inc., Coley Pharmaceutical GmbH, Pfizer Inc.
    Inventors: Arthur M. Krieg, Ulrike Samulowitz, Jörg Vollmer, Eugen Uhlmann, Marion Jurk, Grayson B. Lipford, Robert Rankin
  • TOLEROGENIC SYNTHETIC NANOCARRIERS
    Publication number: 20120276159
    Abstract: This invention relates, at least in part, to compositions comprising synthetic nanocarriers and immunosuppressants that result in immune suppressive effects. Such compositions can further comprise antigen and provide antigen-specific tolerogenic immune responses.
    Type: Application
    Filed: April 27, 2012
    Publication date: November 1, 2012
    Applicant: Selecta Biosciences, Inc.
    Inventors: Christopher Fraser, Grayson B. Lipford, Christopher J. Roy, Roberto A. Maldonado
  • Immunostimulatory Oligonucleotides
    Publication number: 20120213812
    Abstract: Compositions that include immunostimulatory nucleic acids are disclosed, along with the use of such compositions to induce immune responses.
    Type: Application
    Filed: November 16, 2011
    Publication date: August 23, 2012
    Inventors: Grayson B. Lipford, Christopher Fraser