Abstract: A method and system for filling small volume containers, tubes, and wells while maintaining a clean room environment around such containers, tubes, and wells by isolating all engaging moving components of the drive mechanism from the environmental area containing the containers, tubes, or wells. A unitary nozzle support arm extends through a base unit housing the drive mechanism and out over the containers, tubes, or wells intended to be filled. A nozzle mounted to the support arm is preferably in fluid communication with a source of the fluid that is to be analyzed. Optionally, such source may comprise an electronically controlled pump which interfaces with the control unit for the filling system so that both components may be controlled from a single operator interface.