Patents by Inventor Grayson W. Stowell

Grayson W. Stowell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for treating pain
    Patent number: 9233159
    Abstract: Methods and compositions for treating pain are disclosed. The compositions are based on dry powders comprising microparticles of diketopiperazines and an analgesic active agent. The analgesic in the compositions comprises one or more peptide analgesics or derivatives thereof, which are administered to a subject using a pulmonary inhalation drug delivery system comprising a dry powder inhaler and the analgesic composition. The present compositions produce fewer side effects associated with current opioid therapy.
    Type: Grant
    Filed: October 24, 2012
    Date of Patent: January 12, 2016
    Assignees: MannKind Corporation, Torrey Pines Institute for Molecular Studies
    Inventors: Andrea Leone-Bay, Richard A. Houghten, Joseph J. Guarneri, Grayson W. Stowell
  • METHODS AND COMPOSITIONS FOR TREATING PAIN
    Publication number: 20150150980
    Abstract: Methods and compositions for treating pain are disclosed. The compositions are based on dry powders comprising microparticles of diketopiperazines and an analgesic active agent. The analgesic in the compositions comprises one or more peptide analgesics or derivatives thereof, which are administered to a subject using a pulmonary inhalation drug delivery system comprising a dry powder inhaler and the analgesic composition. The present compositions produce fewer side effects associated with current opioid therapy.
    Type: Application
    Filed: February 13, 2015
    Publication date: June 4, 2015
    Inventors: Andrea Leone-Bay, Richard A. Houghten, Joseph J. Guarneri, Grayson W. Stowell
  • METHOD AND COMPOSITION FOR TREATING MIGRAINES
    Publication number: 20140315953
    Abstract: A method for treating migraines is disclosed. The method utilizes a rapid drug delivery system which prevents deactivation or degradation of the active agent, including small molecules and peptides being administered to a patient in need of treatment. In particular, the drug delivery system is designed for inhalation for delivery of drugs to the pulmonary circulation in a rapid and therapeutically effective manner.
    Type: Application
    Filed: June 16, 2014
    Publication date: October 23, 2014
    Inventors: Andrea Leone-Bay, Grayson W. Stowell, Joseph J. Guarneri, Dawn M. Carlson, Marshall Grant, Chad C. Smutney
  • METHODS AND COMPOSITIONS FOR TREATING PAIN
    Publication number: 20140302151
    Abstract: Methods and compositions for treating pain are disclosed. The compositions are based on dry powders comprising microparticles of diketopiperazines and an analgesic active agent. The analgesic in the compositions comprises one or more peptide analgesics or derivatives thereof, which are administered to a subject using a pulmonary inhalation drug delivery system comprising a dry powder inhaler and the analgesic composition. The present compositions produce fewer side effects associated with current opioid therapy.
    Type: Application
    Filed: October 24, 2012
    Publication date: October 9, 2014
    Inventors: Andrea Leone-Bay, Richard A. Houghten, Joseph J. Guarneri, Grayson W. Stowell
  • DIKETOPIPERAZINE MICROPARTICLES WITH DEFINED SPECIFIC SURFACE AREAS
    Publication number: 20140271888
    Abstract: Disclosed herein are diketopiperazine microparticles having a specific surface area of less than about 67 m2/g. The diketopiperazine microparticle can be fumaryl diketopiperazine and can comprise a drug such as insulin.
    Type: Application
    Filed: April 11, 2014
    Publication date: September 18, 2014
    Applicant: MannKind Corporation
    Inventors: Marshall L. Grant, Grayson W. Stowell, Paul Menkin
  • Method and composition for treating migraines
    Patent number: 8785396
    Abstract: A method for treating migraines is disclosed. The method utilizes a rapid drug delivery system which prevents deactivation or degradation of the active agent, including small molecules and peptides being administered to a patient in need of treatment. In particular, the drug delivery system is designed for inhalation for delivery of drugs to the pulmonary circulation in a rapid and therapeutically effective manner.
    Type: Grant
    Filed: November 9, 2011
    Date of Patent: July 22, 2014
    Assignee: Mannkind Corporation
    Inventors: Andrea Leone-Bay, Grayson W. Stowell, Joseph J. Guarneri, Dawn M. Carlson, Marshall Grant, Chad C. Smutney
  • HIGH CAPACITY DIEKTOPIPERAZINE MICROPARTICLES AND METHODS
    Publication number: 20140199398
    Abstract: Disclosed herein are diketopiperazine microparticles having high capacity for adsorbing a drug or active agent. In particular, the diketopiperazine microparticle are formed using fumaryl diketopiperazine and can comprise a drug in large doses for the treatment of disease or disorders by pulmonary delivery via oral inhalation.
    Type: Application
    Filed: June 18, 2012
    Publication date: July 17, 2014
    Applicant: MANNKIND CORPORATION
    Inventors: Marshall Grant, Paul Menkin, Grayson W. Stowell
  • Diketopiperazine microparticles with defined specific surface areas
    Patent number: 8778403
    Abstract: Disclosed herein are diketopiperazine microparticles having a specific surface area of less than about 67 m2/g. The diketopiperazine microparticle can be fumaryl diketopiperazine and can comprise a drug such as insulin.
    Type: Grant
    Filed: September 3, 2013
    Date of Patent: July 15, 2014
    Assignee: Mannkind Corporation
    Inventors: Marshall L. Grant, Grayson W. Stowell, Paul Menkin
  • Val (8) GLP-1 Composition and Method for Treating Functional Dyspepsia and/or Irritable Bowel Syndrome
    Publication number: 20140187490
    Abstract: A method of treating functional dyspepsia and/or irritable bowel syndrome in mammals in need of treatment is disclosed herein. The method comprises administering to the mammal a formulation by inhalation, wherein the formulation avoids first pass metabolism of the active ingredient. The method comprises administering a formulation by pulmonary inhalation comprising a diketopiperazine and a glucagon-like peptide (GLP-1), analog, ROSE-010.
    Type: Application
    Filed: December 23, 2013
    Publication date: July 3, 2014
    Applicants: Rose Pharma A/S, MannKind Corporation
    Inventors: Peter Richardson, Edna Kenny, Per Hellstrom, Marshall L. Grant, Grayson W. Stowell, Scott Daniels, Anthony Smithson, Stephanie Greene
  • Diketopiperazine microparticles with defined specific surface areas
    Patent number: 8734845
    Abstract: Disclosed herein are diketopiperazine microparticles having a specific surface area of less than about 67 m2/g. The diketopiperazine microparticle can be fumaryl diketopiperazine and can comprise a drug such as insulin.
    Type: Grant
    Filed: June 11, 2010
    Date of Patent: May 27, 2014
    Assignee: Mannkind Corporation
    Inventors: Marshall L. Grant, Grayson W. Stowell, Paul Menkin
  • DIKETOPIPERAZINE MICROPARTICLES WITH DEFINED SPECIFIC SURFACE AREAS
    Publication number: 20140045745
    Abstract: Disclosed herein are diketopiperazine microparticles having a specific surface area of less than about 67 m2/g. The diketopiperazine microparticle can be fumaryl diketopiperazine and can comprise a drug such as insulin.
    Type: Application
    Filed: September 3, 2013
    Publication date: February 13, 2014
    Applicant: MannKind Corporation
    Inventors: Marshall L. Grant, Grayson W. Stowell, Paul Menkin
  • Val (8) GLP-1 composition and method for treating functional dyspepsia and/or irritable bowel syndrome
    Patent number: 8642548
    Abstract: A method of treating functional dyspepsia and/or irritable bowel syndrome in mammals in need of treatment is disclosed herein. The method comprises administering to the mammal a formulation by inhalation, wherein the formulation avoids first pass metabolism of the active ingredient. The method comprises administering a formulation by pulmonary inhalation comprising a diketopiperazine and a glucagon-like peptide (GLP-1), analog, ROSE-010.
    Type: Grant
    Filed: August 5, 2010
    Date of Patent: February 4, 2014
    Assignee: Mannkind Corporation
    Inventors: Peter Richardson, Enda Kenny, Per Hellstrom, Marshall L. Grant, Grayson W. Stowell, Scott Daniels, Anthony Smithson, Stephanie Greene
  • Diketopiperazine microparticles with defined specific surface areas
    Patent number: 8551528
    Abstract: Disclosed herein are diketopiperazine microparticles having a specific surface area of less than about 67 m2/g. The diketopiperazine microparticle can be fumaryl diketopiperazine and can comprise a drug such as insulin.
    Type: Grant
    Filed: June 11, 2010
    Date of Patent: October 8, 2013
    Assignee: Mannkind Corporation
    Inventors: Marshall L. Grant, Grayson W. Stowell, Paul Menkin
  • Val (8) GLP-1 Composition and Method for Treating Functional Dyspepsia and/or Irritable Bowel Syndrome
    Publication number: 20120252728
    Abstract: A method of treating functional dyspepsia and/or irritable bowel syndrome in mammals in need of treatment is disclosed herein. The method comprises administering to the mammal a formulation by inhalation, wherein the formulation avoids first pass metabolism of the active ingredient. The method comprises administering a formulation by pulmonary inhalation comprising a diketopiperazine and a glucagon-like peptide (GLP-1), analog, ROSE-010.
    Type: Application
    Filed: August 5, 2010
    Publication date: October 4, 2012
    Inventors: Peter Richardson, Enda Kenny, Per Hellstrom, Marshall L. Grant, Grayson W. Stowell, Scott Daniels, Anthony Smithson, Stephanie Greene
  • Diketopiperazine Microparticles with Defined Specific Surface Areas
    Publication number: 20120164186
    Abstract: Disclosed herein are diketopiperazine microparticles having a specific surface area of less than about 67 m2/g. The diketopiperazine microparticle can be fumaryl diketopiperazine and can comprise a drug such as insulin.
    Type: Application
    Filed: June 11, 2010
    Publication date: June 28, 2012
    Applicant: MANNKIND CORPORATION
    Inventors: Marshall L. Grant, Grayson W. Stowell, Paul Menkin
  • Method and Composition for Treating Migraines
    Publication number: 20120071510
    Abstract: A method for treating migraines is disclosed. The method utilizes a rapid drug delivery system which prevents deactivation or degradation of the active agent, including small molecules and peptides being administered to a patient in need of treatment. In particular, the drug delivery system is designed for inhalation for delivery of drugs to the pulmonary circulation in a rapid and therapeutically effective manner.
    Type: Application
    Filed: November 9, 2011
    Publication date: March 22, 2012
    Applicant: MANNKIND CORPORATION
    Inventors: Andrea Leone-Bay, Grayson W. Stowell, Joseph J. Guarneri, Dawn M. Carlson, Marshall Grant, Chad C. Smutney
  • Diketopiperazine Microparticles with Defined Specific Surface Areas
    Publication number: 20120014999
    Abstract: Disclosed herein are diketopiperazine microparticles having a specific surface area of less than about 67 m2/g. The diketopiperazine microparticle can be fumaryl diketopiperazine and can comprise a drug such as insulin.
    Type: Application
    Filed: June 11, 2010
    Publication date: January 19, 2012
    Inventors: Marshall L. Grant, Grayson W. Stowell, Paul Menkin