Abstract: A method of treating Parkinson's disease in humans is disclosed, wherein glial cell-line derive neurotrophic factor (GDNF) is chronically administered directly to one or both putamen of a human in need of treatment thereof via convection-enhanced infusion using at least one implantable pump and at least one catheter. In one aspect of the present invention the GDNF is infused directly into one or both putamen through one or more indwelling intraparenchymal mutitiport brain catheters connected to one or moreimplantable pumps wherein the flow rate is pulsed.

Abstract: A method of treating Parkinson's disease in humans is disclosed, wherein glial cell-line derive neurotrophic factor (GDNF) is chronically administered directly to one or both putamen of a human in need of treatment thereof via convection-enhanced infusion using at least one implantable pump and at least one catheter. In one aspect of the present invention the GDNF is infused directly into one or both putamen through one or more indwelling intraparenchymal mutitiport brain catheters connected to one or moreimplantable pumps wherein the flow rate is pulsed.

Abstract: A chemical detection and analysis system performs chemical measurements using microsensors. The in vivo or in vitro system records chemical concentrations of any substance that can be oxidized or reduced at the sensor surface in response to a voltage waveform applied to a reference electrode. The electrochemical technique has utility relative to molecules that are electroactive. Diffusion and metabolism of these chemicals are tracked in real time. A visual display of the measurements is provided in near real time. The system consists of: a 32 bit, digital computer; application software; an I/O board with analog to digital convertors, digital to analog converters, and digital input/output capability; a potentiostat; one to four microsensors; and a reference electrode. Calibrated microsensors, of carbon, platinum, or gold, are placed in brain tissue or other aqueous environments to detect chemical activity. A reference electrode is placed in the tissue at a location that is spaced from the sensors.