Abstract: Apparatuses and methods for accessing and disrupting a tissue are disclosed herein. In one embodiment, an apparatus includes a first elongate member having a tissue interaction portion disposed at a distal end of the first elongate member. The tissue interaction portion is configured to be inserted within a biological body. A second elongate member is movably disposed within a lumen defined by the first elongate member. The second elongate member has a threaded exterior surface. A drive motor is coupled to the first elongate member and coupled to the second elongate member. The drive motor is configured to rotate the first elongate member in a first direction and configured to rotate the second elongate member in a second direction opposite the first direction. The tissue interaction portion is configured to disrupt tissue when disposed into the biological body and when the first elongate member is rotated.

Abstract: Apparatuses and methods for accessing and disrupting a tissue are disclosed herein. In one embodiment, an apparatus includes a first elongate member having a tissue interaction portion disposed at a distal end of the first elongate member. The tissue interaction portion is configured to be inserted within a biological body. A second elongate member is movably disposed within a lumen defined by the first elongate member. The second elongate member has a threaded exterior surface. A drive motor is coupled to the first elongate member and coupled to the second elongate member. The drive motor is configured to rotate the first elongate member in a first direction and configured to rotate the second elongate member in a second direction opposite the first direction. The tissue interaction portion is configured to disrupt tissue when disposed into the biological body and when the first elongate member is rotated.

Abstract: Apparatuses and methods for accessing and disrupting a tissue are disclosed herein. In one embodiment, an apparatus includes an elongate member. A distal end portion of the elongate member includes multiple elastically deformable arms that are configured to perform a medical procedure in a biological body. The elastically deformable arms collectively have an unconstrained expanded configuration. Each of the elastically deformable arms has a serrated edge portion. The distal end portion of the elongate member can be rotated while disposed within a biological body such that the serrated edge portion of the arms disrupts tissue within the biological body. The elastically deformable arms can collectively have a collapsed configuration in which the elastically deformable arms define a smaller outer diameter than an outer diameter of the elastically deformable arms in the unconstrained expanded configuration.

Abstract: Apparatuses and methods for accessing and disrupting a tissue are disclosed herein. In one embodiment, a method includes inserting a distal end portion of an elongate member into a biological body. After inserting the elongate member, an actuator is manually actuated to produce translational motion of a drive element. The translational motion is converted into rotational movement of the distal end portion of the elongate member. In one embodiment, an apparatus includes an elongate member having a tissue interaction member at a distal end portion that is configured to be inserted within a biological body. A conversion mechanism is coupled to the elongate member and includes a drive element. An actuator is coupled to the conversion mechanism and is configured to cause translational motion of the drive element. The conversion mechanism is configured to convert the translational motion of the drive element into rotational motion of the elongate member.

Abstract: Apparatuses and methods for accessing and disrupting a tissue are disclosed herein. In one embodiment, a method includes inserting a distal end portion of a medical device into a biological body such that a cutting member disposed at a distal end of the medical device is at a first location within the biological body. A tissue is disrupted at the first location within the biological body. The distal end portion of the medical device is reconfigured from a first configuration in which the distal end portion of the medical device has a first curvature to a second configuration in which the distal end portion of the medical device has a second curvature different than the first curvature and the cutting member is at a second location within the biological body. A tissue is then disrupted at the second location within the biological body.