Patents by Inventor Greg Biesecker

Greg Biesecker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYSTEMATIC EVOLUTION OF LIGANDS BY EXPONENTIAL ENRICHMENT: BLENDED SELEX
    Publication number: 20070134715
    Abstract: A method is described for generating blended nucleic acid ligands containing non-nucleic acid functional units. Specifically, a SELEX identified RNA ligand to the integrin gpIIbIIIa is conjugated to the peptide Gly-Arg-Gly-Asp-Thr-Pro (SEQ ID NO:1). This blended RNA ligand inhibits the biological activity of gpIIbIIIa with high specificity. Also described is a single-stranded DNA ligand to elastase coupled to N-methoxysuccinyl-Ala-Ala-Pro-Val-chloromethyl ketone (SEQ ID NO:2). This elastase blended nucleic acid ligand inhibits the biological activity of elastase.
    Type: Application
    Filed: January 29, 2007
    Publication date: June 14, 2007
    Applicant: GILEAD SCIENCES, INC.
    Inventors: Greg Biesecker, Sumedha Jayasena, Larry Gold, Drew Smith, Gary Kirschenheuter
  • Systematic evolution of ligands by exponential enrichment: blended SELEX
    Publication number: 20030077646
    Abstract: A method is described for generating blended nucleic acid ligands containing non-nucleic acid functional units. Specifically, a SELEX identified RNA ligand to the integrin gpIIbIIIa is conjugated to the peptide Gly-Arg-Gly-Asp-Thr-Pro (SEQ ID NO: 1). This blended RNA ligand inhibits the biological activity of gpIIbIIIa with high specificity. Also described is a single-stranded DNA ligand to elastase coupled to N-methoxysuccinyl-Ala-Ala-Pro-Val-chloromethyl ketone (SEQ ID NO: 2). This elastase blended nucleic acid ligand inhibits the biological activity of elastase.
    Type: Application
    Filed: October 2, 2002
    Publication date: April 24, 2003
    Applicant: GILEAD SCIENCES, INC.
    Inventors: Greg Biesecker, Sumedha D. Jayasena, Larry Gold, Drew Smith, Gary P. Kirschenheuter
  • Systematic evolution of ligands by exponential enrichment: blended selex
    Patent number: 6465189
    Abstract: A method is described for generating blended nucleic acid ligands containing non-nucleic acid functional units. Specifically, a SELEX identified RNA ligand to the integrin gpIIbIIIa is conjugated to the peptide Gly-Arg-Gly-Asp-Thr-Pro (SEQ ID NO:1). This blended RNA ligand inhibits the biological activity of gpIIbIIIa with high specificity. Also described is a single-stranded DNA ligand to elastase coupled to N-methoxysuccinyl-Ala-Ala-Pro-Val-chloromethyl ketone (SEQ ID NO:2). This elastase blended nucleic acid ligand inhibits the biological activity of elastase.
    Type: Grant
    Filed: June 29, 2000
    Date of Patent: October 15, 2002
    Assignee: Gilead Sciences, Inc.
    Inventors: Greg Biesecker, Sumedha Jayasena, Larry Gold, Drew Smith, Gary Kirschenheuter
  • Systematic evolution of ligands exponential enrichment: blended selex
    Patent number: 6083696
    Abstract: A method is described for generating blended nucleic acid ligands containing non-nucleic acid functional units. Specifically, a SELEX identified RNA ligand to the integrin gpIIbIIIa is conjugated to the peptide Gly-Arg-Gly-Asp-Thr-Pro (SEQ ID NO:1). This blended RNA ligand inhibits the biological activity of gpIIbIIIa with high specificity. Also described is a single-stranded DNA ligand to elastase coupled to N-methoxysuccinyl-Ala-Ala-Pro-Val-chloromethyl (SEQ ID NO:3) ketone. This elastase blended nucleic acid ligand inhibits the biological activity of elastase.
    Type: Grant
    Filed: October 23, 1997
    Date of Patent: July 4, 2000
    Assignee: NeXstar Pharmaceuticals, Inc.
    Inventors: Greg Biesecker, Sumedha D. Jayasena, Larry Gold, Drew Smith, Gary Kirschenheuter
  • Systematic evolution of ligands by exponential enrichment: blended SELEX
    Patent number: 5683867
    Abstract: A method is described for generating blended nucleic acid ligands containing non-nucleic acid functional units. Specifically, a SELEX identified RNA ligand to the integrin gpIIbIIIa is conjugated to the peptide Gly-Arg-Gly-Asp-Thr-Pro (SEQ ID NO:1). This blended RNA ligand inhibits the biological activity of gpIIbIIIa with high specificity. Also described is a single-stranded DNA ligand to elastase coupled to N-methoxysuccinyl-Ala-Ala-Pro-Val-chloromethyl (SEQ ID NO:2) ketone. This elastase blended nucleic acid ligand inhibits the biological activity of elastase.
    Type: Grant
    Filed: April 28, 1994
    Date of Patent: November 4, 1997
    Assignee: NeXstar Pharmaceuticals, Inc.
    Inventors: Greg Biesecker, Sumedha D. Jayasena, Larry Gold, Drew Smith, Gary P. Kirschenheuter