Abstract: A fluid laying device includes a manifold block. The manifold block defines a first channel, and also defines a first fluid inlet, a first fluid outlet, and several carrier interfaces. Each carrier interface has a first hole connecting one of a channel inlet and channel outlets of the flow cell carrier. The manifold block is provided with an inlet valve device, a bypass valve device, and outlet valve devices. The inlet valve device and the outlet valve devices are one-to-one corresponding to the carrier interfaces, and disposed on a fluid path from the corresponding carrier interface to the first channel. The first channel includes a first section and a second section. A bypass valve device is between the first and second sections to control connection and disconnection between the first and second sections. The inlet valve device connects the first section, and the outlet valve devices connect the second section.

Abstract: A fluid transportation system and method use a negative pressure driving mode to absorb fluids from a fluid storage assembly and a positive pressure driving mode to load the absorbed fluids into the fluid-using system. At least two working modules are used to transport fluids to the fluid-using system, the process of transporting fluid in each working module being divided into the processes of absorbing fluids into a fluid transfer assembly, and loading fluids into a fluid transfer assembly. The process of absorbing fluids in each working module and the processes of absorbing fluids and/or loading fluids in any other working module overlap at least partially along the time axis. With the present disclosure, the accuracy and speed of fluids transportation are improved, a device utilizing the system and method is also disclosed.

Abstract: The invention provides for devices and methods for interfacing microchips to cartridges and pneumatic manifolds. The design of the cartridges, microchips, and pneumatic manifolds can allow for the use of magnetic forces to capture magnetic beads in a chamber formed between the microchip and the cartridge or a chamber within the microchip. The devices of the invention can be used for mRNA amplification and purification.