Abstract: Described herein are methods, compositions, and systems derived from uncultivated microorganisms useful for gene editing.

Abstract: This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, and R9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.

Abstract: Forward-looking sales activities are poorly served by existing Customer Relationship Managements systems, as the customer information those systems maintain by definition does not include the speculatively interested “leads” pursued in initial sales contacts. An Enrichment database, asynchronously loaded with corporate and optionally individual contact information in anticipation of use, provides real-time access to information in support of such first customer contacts. The Enrichment information may also be used to expedite creation and revision of CRM records.

Abstract: Forward-looking sales activities are poorly served by existing Customer Relationship Managements systems, as the customer information those systems maintain by definition does not include the speculatively interested “leads” pursued in initial sales contacts. An Enrichment database, asynchronously loaded with corporate and optionally individual contact information in anticipation of use, provides real-time access to information in support of such first customer contacts. The Enrichment information may also be used to expedite creation and revision of CRM records.

Abstract: This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, and R9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.

Abstract: Forward-looking sales activities are poorly served by existing Customer Relationship Managements systems, as the customer information those systems maintain by definition does not include the speculatively interested “leads” pursued in initial sales contacts. An Enrichment database, asynchronously loaded with corporate and optionally individual contact information in anticipation of use, provides real-time access to information in support of such first customer contacts. The Enrichment information may also be used to expedite creation and revision of CRM records.

Abstract: This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, and R9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.

Abstract: A manual transmission includes a housing having a longitudinal axis and an aperture, and a shift lever assembly comprising a shift lever having a pivot ball. At least three shift lever sockets are coaxially disposed along the longitudinal axis and within the aperture, with each of the at least three shift lever sockets being configured to receive the pivot ball therein when the shift lever is disposed at a corresponding, different discrete longitudinal position along an axis parallel to the longitudinal axis of the housing. A first shift lever assembly comprises a cover plate and a shift tower supporting the shift lever, wherein the shift tower is substantially centered within a periphery of the cover plate. A second shift lever assembly has a shift tower offset from a center of the periphery of the cover plate.

Abstract: A system and method for vent gas combustion in storage tank for heavy oil production is provided. Auxiliary burners located are provided for combusting the well casing gas. A burner management system for controlling the auxiliary burners is provided which receives a gas pressure value and initiates the auxiliary burners based upon one or more threshold values when the gas pressure exceeds the one or more pressure values. An auxiliary exhaust stack may be collocated with a main exhaust stack of a tank heater for the storage tank.

Abstract: This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, and R9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.

Abstract: A tool attachment 10 comprising a plurality of pick-up pins 32, 34 or excavator bucket pins, each for threading through a pair of spaced apart holes 26 in a mounting part 22 of the tool, a bush 40 for each hole 26, fasteners 44 for fastening each bush to a surround of the respective hole and retainers 46 for each end of each pick-up pin 32, 34, wherein each of the bushes 40 has an eccentric hole 58 there through for receiving a portion of one of the pick-up pins 32, 34 so that the spacing between the pick-up pins 32, 34 can be selected according to the axial orientation of the bushes 40 in relation to the surround 22.

Abstract: This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, and R9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.

Abstract: A system and method for vent gas combustion in storage tank for heavy oil production is provided. Auxiliary burners located are provided for combusting the well casing gas. A burner management system for controlling the auxiliary burners is provided which receives a gas pressure value and initiates the auxiliary burners based upon one or more threshold values when the gas pressure exceeds the one or more pressure values. An auxiliary exhaust stack may be collocated with a main exhaust stack of a tank heater for the storage tank.

Abstract: This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, and R9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.

Abstract: Forward-looking sales activities are poorly served by existing Customer Relationship Managements systems, as the customer information those systems maintain by definition does not include the speculatively interested “leads” pursued in initial sales contacts. An Enrichment database, asynchronously loaded with corporate and optionally individual contact information in anticipation of use, provides real-time access to information in support of such first customer contacts. The Enrichment information may also be used to expedite creation and revision of CRM records.

Abstract: A system for creating composite encoded video from two or more encoded video sources in the encoded domain. In response to user input, a markup language-based graphical layout is retrieved. The graphical layout includes frame locations within a composite frame for at least a first encoded source and a second encoded source. The system either retrieves or receives the first and second encoded sources. The sources include block-based transform encoded data. The system also includes a stitcher module for stitching together the first encoded source and the second encoded source according to the frame locations of the graphical layout to form an encoded frame. The system outputs an encoded video stream that is transmitted to a client device associated with the user. In response to further user input, the system updates the state of an object model and replaces all or a portion of one or more frames of the encoded video stream. The system may be used with MPEG encoded video.

Abstract: This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, and R9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.

Abstract: This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, and R9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.

Abstract: Systems and methods for interfacing interactive content items and shared data variables include electronically generating a first program interface to provide a module for creating one or more interactive content items (e.g., new graphical user interfaces or other activities). A second program interface is also electronically generated to provide a module for creating one or more shared data variables (e.g., data tables or the like) and for entering data into such shared data variables. Features are also provided to generate a third program interface for defining instructions to reference one or more shared data variables from an interactive content item. The instructions created using the third program interface are electronically executed to populate one or more elements in the interactive content item with data from one or more of the shared data variables.

Abstract: This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, and R9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.