Abstract: A terminally sterilized isotope generator for producing an alpha-emitting Lead-212 (212Pb) daughter isotope by emanation of Radon-220 (220Rn) gas from Radium-224, comprising a closed retainer assembly including a parent-isotope chamber for receiving a parent isotope, a daughter-isotope chamber for collecting the 212Pb daughter isotope, and a gas permeable membrane separating the parent-isotope chamber from the daughter-isotope chamber, wherein the parent isotope is naturally decaying into 220Rn within the parent-isotope chamber, wherein the gas permeable membrane allows the 220Rn to passively pass therethrough, wherein the 220Rn is spontaneously decaying into 212Pb within the daughter-isotope chamber. An eluent is delivered in the daughter-isotope chamber, to elute in a liquid form the 212Pb generated in a gaseous form; and a collection container collects the 212Pb daughter-isotope eluted.

Abstract: Systems and methods for formulating a radioactive liquid using a disposable container are described. The disposable container includes a flexible sidewall defining an interior space for containing the radioactive liquid during formulation. The flexible sidewall is constructed of sterile, pyrogen-free material to prevent contamination of the radioactive liquid. The flexible sidewall includes a first portion and a second portion. The disposable container also includes an access port and a dispense port. The access port is defined by the first portion of the flexible sidewall to provide access to the interior space. The dispense port is defined by the second portion of the flexible sidewall for the radioactive liquid within the interior space to be dispensed through.

Abstract: Systems and methods for formulating a radioactive liquid using a disposable container are described. The disposable container includes a flexible sidewall defining an interior space for containing the radioactive liquid during formulation. The flexible sidewall is constructed of sterile, pyrogen-free material to prevent contamination of the radioactive liquid. The flexible sidewall includes a first portion and a second portion. The disposable container also includes an access port and a dispense port. The access port is defined by the first portion of the flexible sidewall to provide access to the interior space. The dispense port is defined by the second portion of the flexible sidewall for the radioactive liquid within the interior space to be dispensed through.