Abstract: Systems, devices and methods for knotless fixation of tissue during a surgical procedure, including a multi-piece anchor having a separate distal anchor and cannulated proximal anchor component that are used to secure one or more sutures for surgical tissue repair without requiring suture knots. The distal body can include a closed aperture to allow insertion and/or free sliding of one or more suture strands. The multi-piece anchor is secured in a hole formed in bone by placing the distal anchor body in the hole and then advancing the proximal anchor component, such as a cannulated interference screw body, over a portion of the distal anchor body.