Abstract: The present disclosure provides methods and systems for preparing and using contrived nucleic acid samples for process validation and control. The contrived nucleic acid samples have prescribed specific physical and chemical characteristics, and are present in quantities sufficient to validate and confirm large-scale sequencing processes. Method validation may require known samples to confirm expected outcomes of the processes being validated. The inherent biological variability of biological samples obtained from individuals may not be suitable for the rigid requirements of process validation. The contrived biological samples described herein may approximate the complexity and biological features of a biological sample in a known and defined manner that may be controlled accordingly for the processes being validated.

Abstract: Methods and systems provided herein address current limitations of bisulfite-based methylation sequencing by improving the quality and accuracy of nucleic acid methylation sequencing and uses thereof for detection of disease. Methods that include minimally-destructive conversion methods for methylation sequencing as well as specialized UMI adapters provide for improved quality of sequencing libraries and sequencing information. Greater accuracy and more complete methylation-state information permits higher quality feature generation for use in machine learning models and classifier generation.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable media for automated fleet tracking. A route management system enables fleet managers to define and assign routes for vehicles in a fleet, as well as set route tracking configurations for customized tracking of the vehicles. For example, the route tracking configuration may include customizations to the scheduled start and/or end time of a route, a threshold for determining that a vehicle has arrived and/or departed from a scheduled stop, and the like.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable media for automated fleet tracking. A route management system enables fleet managers to define and assign routes for vehicles in a fleet, as well as set route tracking configurations for customized tracking of the vehicles. For example, the route tracking configuration may include customizations to the scheduled start and/or end time of a route, a threshold for determining that a vehicle has arrived and/or departed from a scheduled stop, and the like.

Abstract: Disclosed are systems, methods, and non-transitory computer-readable media for automated fleet tracking. A route management system enables fleet managers to define and assign routes for vehicles in a fleet, as well as set route tracking configurations for customized tracking of the vehicles. For example, the route tracking configuration may include customizations to the scheduled start and/or end time of a route, a threshold for determining that a vehicle has arrived and/or departed from a scheduled stop, and the like.

Abstract: Methods and systems provided herein address current limitations of bisulfate-based methylation sequencing by improving the quality and accuracy of nucleic acid methylation sequencing and uses thereof for detection of disease. Methods that include minimally-destructive conversion methods for methylation sequencing as well as specialized UMI adapters provide for improved quality of sequencing libraries and sequencing information. Greater accuracy and more complete methylation-state information permits higher quality feature generation for use in machine learning models and classifier generation.

Abstract: A method to provide additional gaming network functionality links a user's gaming network identity with the user's social network identity. Linkage of the user's gaming network and social network identities establishes a two way communication link by which a gaming (social) network service can obtain information from, and send information to, a social (gaming) network service on behalf of the user. The gaming (social) network service may obtain information regarding the social (gaming) network relationships of the user's social (gaming) network identity and suggest gaming (social) network relationships to the user based on the social (gaming) network relationships. The gaming (social) network service additionally enables a user having linked identities to post gaming (social) network related messages as social (gaming) network messages via their social (gaming) network identity.

Abstract: A method to provide additional gaming network functionality links a user's gaming network identity with the user's social network identity. Linkage of the user's gaming network and social network identities establishes a two way communication link by which a gaming (social) network service can obtain information from, and send information to, a social (gaming) network service on behalf of the user. The gaming (social) network service may obtain information regarding the social (gaming) network relationships of the user's social (gaming) network identity and suggest gaming (social) network relationships to the user based on the social (gaming) network relationships. The gaming (social) network service additionally enables a user having linked identities to post gaming (social) network related messages as social (gaming) network messages via their social (gaming) network identity.

Abstract: A method to provide additional gaming network functionality links a user's gaming network identity with the user's social network identity. Linkage of the user's gaming network and social network identities establishes a two way communication link by which a gaming (social) network service can obtain information from, and send information to, a social (gaming) network service on behalf of the user. The gaming (social) network service may obtain information regarding the social (gaming) network relationships of the user's social (gaming) network identity and suggest gaming (social) network relationships to the user based on the social (gaming) network relationships. The gaming (social) network service additionally enables a user having linked identities to post gaming (social) network related messages as social (gaming) network messages via their social (gaming) network identity.

Abstract: A method to provide additional gaming network functionality links a user's gaming network identity with the user's social network identity. Linkage of the user's gaming network and social network identities establishes a two way communication link by which a gaming (social) network service can obtain information from, and send information to, a social (gaming) network service on behalf of the user. The gaming (social) network service may obtain information regarding the social (gaming) network relationships of the user's social (gaming) network identity and suggest gaming (social) network relationships to the user based on the social (gaming) network relationships. The gaming (social) network service additionally enables a user having linked identities to post gaming (social) network related messages as social (gaming) network messages via their social (gaming) network identity.