Abstract: Needle devices for accessing tissue at a desired location within a patient's body in order to deliver biologic, chemical or other therapeutic agents to the tissue, or obtain a sample of the tissue, or to obtain a sample of body fluid or otherwise drain body fluid from the body of a patient, and secured after access to the tissue node is described. The needle device includes a hub, a needle and a stabilizing wire. Securing the needle can be accomplished via stabilizing wire with a helical tissue engagement portion, which can be introduced via an open needle tip or a lumen aperture. The stabilizing wire may be attached to a slidable trigger on the hub. Fluid can be introduced into the needle device through an injection port in the hub with an extension element thereon.

Abstract: An implant delivery system is described, having a distal tip and outer sheath that remain in a fixed position during implant delivery. A pusher mechanism within the sheath pushes an implant out of a gap between a distal end of the sheath and the distal tip.

Abstract: An implant delivery system is described, having a distal tip and outer sheath that remain in a fixed position during implant delivery. A pusher mechanism within the sheath pushes an implant out of a gap between a distal end of the sheath and the distal tip.

Abstract: An implant delivery system is described, having a distal tip and outer sheath that remain in a fixed position during implant delivery. A pusher mechanism within the sheath pushes an implant out of a gap between a distal end of the sheath and the distal tip.

Abstract: An implant delivery system is described, having a distal tip and outer sheath that remain in a fixed position during implant delivery. A pusher mechanism within the sheath pushes an implant out of a gap between a distal end of the sheath and the distal tip.

Abstract: A system for treatment of a vessel lesion comprises an expandable balloon and at least one cutting blade engaged to an exterior surface of the balloon. At least a portion of the cutting blade has a substantially serpentine configuration defined by a plurality of interconnected peaks and troughs wherein each trough is in closer proximity to the balloon than each peak.

Abstract: A tool for imparting a plurality of folds to a balloon comprises a housing, which defines a passage therethrough. The passage has a longitudinal axis and a first opening at a first end of the passage, and a second opening at a second end of the passage. The passage has an inner surface, which defines a plurality of peaks and valleys, wherein the height of each peak is greater at the first end of the passage than at the second end of the passage and the height of each valley is greater at the first end of the passage than at the second end of the passage.