Abstract: A phage dispensing method, phage dispensing apparatus a phage dispensing system configured to dispense a phage prescription. A dose calculation is performed using the patient weight, the target phage dose, a titer of a phage vial and a contaminant level of a phage vial to determine a dispensing set and associated dispensing volumes from phage vials stored in a phage storage apparatus. Storage locations and dose preparation instructions including respective dispensing volumes are provided to a pharmacist and a verification of the vials is performed to check the correct vials are removed from the phage storage apparatus.

Abstract: A phage dispensing system comprises a user interface, a phage treatment computing system, a phage laboratory, and a phage dispensing apparatus, including a dispensing kiosk. The user interface allows a treating physician to request testing of a patient sample by the phage laboratory to identify a phage mixture treatment. The phage computing system arranges shipping of the sample and provision of the identified phage mixture treatment to a dispensing apparatus located near the patient. The dispensing apparatus has a stock of phage vials which are used to prepare and dispense doses of the identified phage mixture treatment.

Abstract: A phage dispensing system comprises a user interface, a phage treatment computing system, a phage laboratory, and a phage dispensing apparatus, including a dispensing kiosk. The user interface allows a treating physician to request testing of a patient sample by the phage laboratory to identify a phage mixture treatment. The phage computing system arranges shipping of the sample and provision of the identified phage mixture treatment to a dispensing apparatus located near the patient. The dispensing apparatus has a stock of phage vials which are used to prepare and dispense doses of the identified phage mixture treatment.

Abstract: A method of selecting a phage formulation is described wherein the method comprises storing bacterial infection/contamination data at one or more treatment locations in a spatio-temporal infection database, the database comprising at least one of the following data fields: (1) a clinical indication, (2) a bacteria identification, (3) a clinical outcome, (4) a phage resistance status, (5) a phage susceptibility profile, (6) an antibiotic susceptibility profile, and/or (7) a lab test result relating to any one of (1)-(6); identifying one or more phage suitable for inclusion in the phage formulation by analyzing the data fields of (1)-(7) in the database to identify to one or more infections associated with a treatment location during a historical time period based at least on one or more of a frequency of infections/contamination, a geographic clustering of infections/contamination, and/or phage usage data; and generating a selected list of phage to be included in the phage formulation.

Abstract: A computer implemented method of generating a machine learning model for interpreting host phage response data comprising receiving datasets and labels for a host phage response, training a machine learning model and using this model to estimate the efficacy of a test phage in inhibiting growth of a test bacteria.

Abstract: A phage dispensing system comprises a user interface, a phage treatment computing system, a phage laboratory, and a phage dispensing apparatus, including a dispensing kiosk. The user interface allows a treating physician to request testing of a patient sample by the phage laboratory to identify a phage mixture treatment. The phage computing system arranges shipping of the sample and provision of the identified phage mixture treatment to a dispensing apparatus located near the patient. The dispensing apparatus has a stock of phage vials which are used to prepare and dispense doses of the identified phage mixture treatment.

Abstract: A safe, physically demanding interface device for children or other users to play video games according to the present invention includes a base and a joystick or control rod. The base supports a significant portion or the entirety of the child weight (e.g., supports a child in a seated or standing position), while the joystick is manipulable by the child to play the games. The device is configured to force the child to utilize many of the large muscle groups to interact with the game. Since the child weight is supported by the base, the interface device is stable (e.g., unlikely to tip or move) and, therefore, provides for safe, compelling video game play for users either alone or with other users.

Abstract: An isometric exercise system according to the present invention facilitates user interaction with a host computer system and includes at least one effector, at least one sensor coupled to the effector, a platform to accommodate the user and control circuitry including a processor. The platform accommodates a user and includes the effector attached thereto. The sensor measures at least one force applied by a user to the effector, where the applied force effects a strain on or deflects the effector. The processor receives and processes data corresponding to applied force information measured by the sensor for transference to the host computer system in a compatible format and facilitates user interaction with the host computer system via effector manipulation by the user. The host computer system processes the information to update or respond to events within an executing software application (e.g., a game).

Abstract: The present invention embodiments promote performance of exercise by users during a computer simulation or game. An embodiment of the present invention includes an exercise device with a plurality of effector or gripping members in the form of handles to be manipulated by a user. A coil steel spring provides the resistance for the handles that may be compressed together or pulled apart for resistance-based exercise. The device further includes additional input devices to interact with a simulation or gaming scenario. The user applies forces to the handles to interact with the scenario, thereby requiring the user to perform exercises during the simulation or game play.

Abstract: A motion platform system includes a support and a motion platform supported by the support and rotatable about a plurality of bearing axes The motion platform is further rotatable with respect to the support about at least one axis that is offset from the plurality of bearing axes. The motion platform may include an intermediate frame supported by the support, where the intermediate frame is rotatable about a first bearing axis with respect to the support. The motion platform may further include an inner frame supported by the intermediate frame, where the inner frame is rotatable about a second bearing axis with respect to the intermediate frame. Rotations of the inner and intermediate frames about the first and second bearing axes facilitate rotation of the inner frame with respect to the support about at least one axis offset from the bearing axes.

Abstract: The present invention embodiments promote performance of exercise by users during a video or computer game by enabling a user to perform exercises to interact with the game. An embodiment of the present invention includes an exercise gaming device with a plurality of effector or gripping members in the form of handles to be manipulated by a user. The exercise gaming device further includes additional input devices to interact with a simulation or gaming scenario. The user applies forces to the handles to interact with the gaming scenario, thereby requiring the user to perform exercises during game play. The exercise gaming device may employ various damping mechanisms to provide resistance to the handles for the user. Alternatively, the handles may be fixedly attached to the exercise gaming device to resist the applied forces and provide isometric exercises for the user.

Abstract: A force measurement system includes an effector device with a hollow interior, an inner support secured within the hollow interior of the effector device, and at least one sensor secured at a selected location to the inner support and configured to measure a force applied to the inner support. At least one outer surface portion of the inner support is coupled with at least one interior surface portion of the effector device such that forces applied to the effector device are at least partially transferred to the inner support for measurement by the sensor.

Abstract: An interface, in the form of an isometric exercise system, according to the present invention includes an effector with at least one sensor, a platform and control circuitry including a processor. The platform accommodates a user in a standing position and includes the effector attached thereto. The sensor measures at least one force applied by a user lower body portion to the effector and causing a measurable strain on the effector. An additional effector with at least one sensor and a game controller or other input device may further be attached to the platform. The sensor measures at least one force applied by a user upper body portion to the additional effector and causing a measurable strain on that effector. The processor receives and processes data corresponding to applied force information for transference to the host computer system to update a virtual reality scenario.

Abstract: A game controller according to the present invention enables a user to perform exercises to control a gaming or virtual reality scenario. The game controller or exercise device includes an exercise structure and control circuitry. The exercise structure enables a user seated on a rotatable support member to apply forces to rotate the support member and user body. The rotation of the user on the exercise structure is measured and utilized to control the game scenario.

Abstract: An interface, in the form of an isometric exercise system, according to the present invention includes an effector with at least one sensor, a platform and control circuitry including a processor. The platform accommodates a user in a standing position and includes the effector attached thereto. The sensor measures at least one force applied by a user lower body portion to the effector and causing a measurable strain on the effector. An additional effector with at least one sensor and a game controller or other input device may further be attached to the platform. The sensor measures at least one force applied by a user upper body portion to the additional effector and causing a measurable strain on that effector. The processor receives and processes data corresponding to applied force information for transference to the host computer system to update a virtual reality scenario.

Abstract: A force measurement system includes an effector device with a hollow interior, an inner support secured within the hollow interior of the effector device, and at least one sensor secured at a selected location to the inner support and configured to measure a force applied to the inner support. At least one outer surface portion of the inner support is coupled with at least one interior surface portion of the effector device such that forces applied to the effector device are at least partially transferred to the inner support for measurement by the sensor.

Abstract: A game controller, according to the present invention, interacts with a plurality of different game processors including different gaming applications utilizing a communication link. The game controller includes a plurality of user-manipulable input devices, and at least one signal processor to receive and process signals associated with manipulations of the user-manipulable input devices and to communicate with a plurality of different game processors. The communication link includes a plurality of connection plugs, where at least two of the connection plugs are configured to connect with different game processors. In addition, the communication link may facilitate wired or wireless transfer of signals between the at least one signal processor and a selected game processor, where a wired transfer may employ an extension cable to cover greater distances.

Abstract: An isometric exercise system according to the present invention facilitates user interaction with a host computer system and includes at least one effector, at least one sensor coupled to the effector, a platform to accommodate the user and control circuitry including a processor. The platform accommodates a user and includes the effector attached thereto. The sensor measures at least one force applied by a user to the effector, where the applied force effects a strain on or deflects the effector. The processor receives and processes data corresponding to applied force information measured by the sensor for transference to the host computer system in a compatible format and facilitates user interaction with the host computer system via effector manipulation by the user. The host computer system processes the information to update or respond to events within an executing software application (e.g., a game).

Abstract: A motion platform system includes a support and a motion platform supported by the support and rotatable about a plurality of bearing axes. The motion platform is further rotatable with respect to the support about at least one axis that is offset from the plurality of bearing axes. The motion platform may include an intermediate frame supported by the support, where the intermediate frame is rotatable about a first bearing axis with respect to the support. The motion platform may further include an inner frame supported by the intermediate frame, where the inner frame is rotatable about a second bearing axis with respect to the intermediate frame. Rotations of the inner and intermediate frames about the first and second bearing axes facilitate rotation of the inner frame with respect to the support about at least one axis offset from the bearing axes.

Abstract: A safe, physically demanding interface device for children or other users to play video games according to the present invention includes a base and a joystick or control rod. The base supports a significant portion or the entirety of the child weight (e.g., supports a child in a seated or standing position), while the joystick is manipulable by the child to play the games. The device is configured to force the child to utilize many of the large muscle groups to interact with the game. Since the child weight is supported by the base, the interface device is stable (e.g., unlikely to tip or move) and, therefore, provides for safe, compelling video game play for users either alone or with other users.