Abstract: Disclosed herein is a multi-electrode catheter system including an amplifier stage and an amplifier interface. The amplifier stage includes at least a first quantity of amplifier channels. The amplifier interface includes a first interface having at least the first quantity of interface channels. The amplifier channels are respectively electrically coupled to the interface channels. The amplifier interface includes a second interface having a second quantity of catheter channels, the second quantity being greater than the first quantity. The catheter channels are configured to be respectively electrically coupled to corresponding electrode leads of a multi-electrode catheter. The amplifier interface includes a switching matrix electrically coupled between the first interface and the second interface. The switching matrix is configured to selectively electrically couple a selected subset of catheter channels to respective interface channels of the first quantity of interface channels.

Abstract: A catheter includes a shaft including a proximal end and a distal end, an electrical conductor coupled to the catheter, and an electrode coupled to the electrical conductor. The electrode includes at least one recessed portion, and an impedance reduction layer disposed in the at least one recessed portion. The impedance reduction layer has a thickness less than a depth of the recessed portion.

Abstract: Disclosed herein is a multi-electrode catheter system including an amplifier stage and an amplifier interface. The amplifier stage includes at least a first quantity of amplifier channels. The amplifier interface includes a first interface having at least the first quantity of interface channels. The amplifier channels are respectively electrically coupled to the interface channels The amplifier interface includes a second interface having a second quantity of catheter channels, the second quantity being greater than the first quantity. The catheter channels are configured to be respectively electrically coupled to corresponding electrode leads of a multi-electrode catheter. The amplifier interface includes a switching matrix electrically coupled between the first interface and the second interface. The switching matrix is configured to selectively electrically couple a selected subset of catheter channels to respective interface channels of the first quantity of interface channels.

Abstract: An aluminum alloy with high strength at high temperature includes an aluminum matrix with over 80 molar % aluminum and L12 precipitate phases having a maximum dimension no greater than 20 nm in the aluminum matrix. The L12 precipitate phases have a formula of Al3M, wherein M in the L12 precipitate phases comprises at least one of erbium and zirconium. This alloy and other compositions as well as the processing conditions for producing the compositions can be formulated via a computer-implemented method involving evaluation of material properties of simulated products formed from a plurality of precursor compositions.

Abstract: Described is a steerable catheter assembly including an elongated catheter shaft with a steerable section that can be articulated to navigate the catheter shaft through a tortuous path through a patient's vasculature. The steerable section includes a planarity member(s) disposed within and fixedly attached (e.g., row of holes extending along a length of the planarity member). The planarity member extend along the centerline of the steerable section. The planarity member has a cross-sectional area perpendicular to the centerline. The cross-sectional area has a maximum principal area moment of inertia of at least 5 times a minimum principal area moment of inertia. The catheter shaft also includes a deflection lumen offset from the planarity member, and a pull wire disposed within the deflection lumen and operable to induce deflection of the elongated catheter shaft section.

Abstract: Embodiments of the present disclosure describe hybrid catheters having flexible array of electrodes configured for both mapping and high power ablation delivery. In one embodiment, a hybrid mapping and ablation catheter having a planar assembly with a plurality of flexible arms and a plurality of electrodes disposed on each arm of the plurality of flexible arms, wherein at least one arm comprises: a first lumen housing a strut that extends along a length of at least one of the flexible arms; and a second lumen and a third lumen housing a conductive wire configured to independently energize one or more of the plurality of electrodes disposed on the flexible arm to deliver pulsed field ablation energy to a tissue is provided.

Abstract: A multi-electrode assembly of the present disclosure includes a plurality of electrodes; and an electrode support member; wherein a portion of the electrode support member is adapted to selectively ablate a tissue in contact therewith, and at least a portion of the electrodes are configured and arranged on the electrode support member to detect electrophysiological characteristics of the tissue. The electrode support member can be constructed of flexible material and shaped to facilitate contact with certain anatomical structures (e.g., linear, loop, spiral, planar array, or basket shapes). Embodiments described enable selective activation of the electrode support member for ablation and selective activation of electrodes for electrophysiological mapping and/or ablation.

Abstract: A catheter assembly is provided. The catheter assembly includes a catheter including at least one lesion generating electrode, the at least one lesion generating electrode configured to be positioned within a patient, and at least one return array configured to be positioned within the patient and remote from the at least one lesion generating electrode, the at least one return array including at least one return electrode, wherein the catheter assembly is configured to apply energy between i) the at least one lesion generating electrode and ii) a return patch and the at least one return electrode to generate lesions proximate the at least one lesion generating electrode.

Abstract: A treadmill for backward walking is disclosed. The treadmill may include a static frame and dynamic platform pivotally mounted to the static frame. A C-shaped support handle includes side portions that may be grasped or otherwise used by a user to stabilize their position, and a cross member against which the user may lean, e.g. with the user's hips or back. A user may press against a treadmill belt with the user's feet, against resistance from a brake, to move the treadmill belt away from the user's body.

Abstract: Materials, methods and techniques relate to steel alloys. In some instances, steel alloys can include chromium, molybdenum, vanadium, copper, nickel, manganese, niobium, aluminum, and iron. In some instances, exemplary steel alloys are subjected to solution carburizing, tempering, and/or plasma nitriding. Exemplary steel alloys are typically precipitation strengthened carburizable and nitridable steel alloys.

Abstract: A treadmill for backward walking is disclosed. The treadmill may include a static frame and dynamic platform pivotally mounted to the static frame. A C-shaped support handle includes side portions that may be grasped or otherwise used by a user to stabilize their position, and a cross member against which the user may lean, e.g. with the user's hips or back. A user may press against a treadmill belt with the user's feet, against resistance from a brake, to move the treadmill belt away from the user's body.

Abstract: Exemplary alloys may comprise, by weight percentage, 13.25% to 14.75% chromium; 4.5% to 5.5% nickel; 0.11% to 0.17% carbon; 0.01% to 0.31% titanium; and the balance of weight percent comprising iron and incidental elements and impurities. Exemplary methods may include conducting additive manufacturing with an atomized alloy powder to generate a manufactured article, where the atomized alloy powder may comprise, by weight percentage, 13.25% to 14.75% chromium; 4.5% to 5.5% nickel; 0.11% to 0.17% carbon; 0.01% to 0.31% titanium; and the balance of weight percent comprising iron and incidental elements and impurities.

Abstract: The present disclosure provides electroporation catheters that are capable of forming a loop, generally a circular loop, an oval loop, or like in shape, located on the distal end portion of a catheter shaft within the vasculature of an individual. The electroporation catheters of the present disclosure may be delivered into the vasculature of the individual in a straight conformation and allow for the formation of the loop once positioned in the desired location. Some embodiments of the present disclosure include an electroporation catheter that includes a loop member pull wire in a spiral or helical configuration on an inside surface of the distal end portion of the catheter shaft.

Abstract: A method of navigating a catheter to a target location in an anatomical structure of a patient includes inserting a portion of a catheter into the patient. The catheter includes an elongate shaft having a proximal and a distal end, and a loop subassembly coupled to the distal end. The loop subassembly includes a loop coupled to the distal end and positioned parallel to the elongate shaft, and electrodes disposed on the loop. The method includes positioning one of a portion of the loop subassembly and a portion of the distal end of the elongate shaft in contact with a surface of the anatomical structure a distance from the target location, and translating the loop subassembly toward the target location with the one of the portion of the loop subassembly and the portion of the distal end of the elongate shaft in contact with the surface of the anatomical structure.

Abstract: A catheter assembly is provided. The catheter assembly includes a tip electrode array including at least one tip electrode, the tip electrode array located at a distal end of the catheter assembly, and a mini electrode array including a plurality of mini electrodes, the mini electrode array positioned proximal of the tip electrode array, wherein each of the at least one tip electrode and each of the plurality of mini electrodes are configured to be activated independent of one another for mapping applications, and wherein at least some of the at least one tip electrode and the plurality of mini electrodes are configured to be activated in unison for ablation applications.

Abstract: A catheter includes a shaft including a proximal end and a distal end, an electrical conductor coupled to the catheter, and an electrode coupled to the electrical conductor. The electrode includes at least one recessed portion, and an impedance reduction layer disposed in the at least one recessed portion. The impedance reduction layer has a thickness less than a depth of the recessed portion.

Abstract: The present disclosure provides electroporation catheters that are capable of forming a loop, generally a circular loop, an oval loop, or like in shape, located on the distal end portion of a catheter shaft within the vasculature of an individual. The electroporation catheters of the present disclosure may be delivered into the vasculature of the individual in a straight conformation and allow for the formation of the loop once positioned in the desired location. Some embodiments of the present disclosure include an electroporation catheter that includes a loop member pull wire in a spiral or helical configuration on an inside surface of the distal end portion of the catheter shaft.

Abstract: A treadmill for backward walking is disclosed. The treadmill may include a static frame and dynamic platform pivotally mounted to the static frame. A C-shaped support handle includes side portions that may be grasped or otherwise used by a user to stabilize their position, and a cross member against which the user may lean, e.g. with the user's hips or back. A user may press against a treadmill belt with the user's feet, against resistance from a brake, to move the treadmill belt away from the user's body.

Abstract: Exemplary martensitic steel alloys may be particularly suited for additive manufacturing applications. Exemplary atomized alloy powders usable in additive manufacturing may include carbon, nickel, manganese, chromium, and the balance iron and incidental impurities. Exemplary steel alloys can be molybdenum free.

Abstract: A method of forming a spline for an electrode assembly includes providing a structural member including a first surface and a second surface. The method also includes providing a flexible circuit assembly including a plurality of electrodes and at least one flexible circuit substrate having a contact surface and an outer surface opposite the contact surface. The plurality of electrodes are disposed on the outer surface of the at least one flexible circuit substrate. The method includes positioning the flexible circuit assembly relative to the structural member such that a first set of electrodes is aligned with the first surface and a second set of electrodes is aligned with the second surface. The method also includes coupling the at least one flexible circuit substrate to at least one of the structural member and the at least one flexible circuit substrate.