Abstract: The invention relates, in part, to compositions and methods for validating antibodies utilizing immunoprecipitation and mass spectrometry.

Abstract: The present invention relates to fungal histidine kinases. In particular, the present invention is directed to histidine kinases from Neurospora (e.g., N. crassa), Candida (e.g, C. albicans), and Aspergillus (e.g., A. fumigatus), and related compositions. Furthermore, the present invention provides compositions and methods for the identification of compounds having antifungal activity, as well as compositions and methods for the treatment of fungal infections.

Abstract: Improvements to integrated blood pump/oxygenator having a rotating hollow fiber bundle assembly that both oxygenates and pumps blood are provided. An inner member arranged along a central axis of the device accelerates blood entering the fiber bundle to reduce microbubble generation and blood trauma. Shearing loads imposed on the fiber elements of the fiber bundle are reduced by the addition of a reinforcement structure, while the gas flow path is configured to reduce flooding and loss of oxygenation efficiency due to occasional rupture of fiber elements.

Abstract: An integrated blood pump/oxygenator having a rotating hollow fiber bundle assembly that both oxygenates and pumps blood is provided that includes a plurality of partitions disposed within or about the fiber bundle assembly to lengthen the flow path of blood passing through the fiber bundle. Alternatively, or in addition, blood flow paths may be lengthened and oxygenation improved by providing internal recirculation paths within the pump/oxygenator, which also advantageously may be used to reduce blood trauma caused by stagnation nearing moving parts and heat build-up.