Abstract: Memory devices and systems with post-packaging master die selection, and associated methods, are disclosed herein. In one embodiment, a memory device includes a plurality of memory dies. Each memory die of the plurality includes a command/address decoder. The command/address decoders are configured to receive command and address signals from external contacts of the memory device. The command/address decoders are also configured, when enabled, to decode the command and address signals and transmit the decoded command and address signals to every other memory die of the plurality. Each memory die further includes circuitry configured to enable, or disable, or both individual command/address decoders of the plurality of memory dies. In some embodiments, the circuitry can enable a command/address decoder of a memory die of the plurality after the plurality of memory dies are packaged into a memory device.

Abstract: A material handling system includes a conveyor, an actuation unit, and a chute. The chute is mechanically coupled to the conveyor at a defined angle with respect to a surface of the conveyor. The chute includes an inlet defining a first end and a second end, where the first end of the inlet is mechanically coupled to the surface of the conveyor. Further, the chute includes at least one tube configured to be rotated by the actuation unit at a defined rotational speed. The chute also includes an outlet mechanically coupled to the at least one tube. In this aspect, the defined angle and the defined rotational speed is based on at least one of: physical characteristic of an item to be passed through the chute, a rate of inflow of the item through the inlet, and a rate of outflow of the item through the outlet.

Abstract: A material handling system includes a conveyor, an actuation unit, and a chute. The chute is mechanically coupled to the conveyor at a defined angle with respect to a surface of the conveyor. The chute includes an inlet defining a first end and a second end, where the first end of the inlet is mechanically coupled to the surface of the conveyor. Further, the chute includes at least one tube configured to be rotated by the actuation unit at a defined rotational speed. The chute also includes an outlet mechanically coupled to the at least one tube. In this aspect, the defined angle and the defined rotational speed is based on at least one of: physical characteristic of an item to be passed through the chute, a rate of inflow of the item through the inlet, and a rate of outflow of the item through the outlet.

Abstract: According to the embodiments described herein, a SUMOylation inhibitor compound comprising a singleton scaffold is provided. In some embodiments, a method for inhibiting a SUMOylation enzyme in a cell is provided. Such a method may include administering a SUMOylation inhibitor compound to the cell. In some aspects, the SUMOylation enzyme is SUMO E1 or SUMO E2. In some aspects, the method may be used to inhibit a cancer cell in vitro (e.g., grown in culture) or in vivo (e.g., as part of a tumor in a subject). In other embodiments, a method for treating a cancer, degenerative diseases and viral infection is provided. Such a method may include administering an effective amount of a pharmaceutical composition to a subject having the cancer. The pharmaceutical composition may include a singleton SUMOylation inhibitor compound.

Abstract: According to the embodiments described herein, a methods for inhibiting small ubiquitin-like modifier enzymes in a cell are provided. Such methods may include administering certain substituted pyrrolo[2,3-b]-quinoxalines to the cell. In some aspects, the small ubiquitin-like modifier enzyme is SUMO E1 or SUMO E2. In some aspects, the methods may be used to inhibit a cancer cell in vitro (e.g., grown in culture) or in vivo (e.g., as part of a tumor in a subject). In other embodiments, methods for treating a cancer, degenerative diseases and viral infection are provided. Such methods may include administering an effective amount of a pharmaceutical composition to a subject having cancer. The pharmaceutical composition may include a small ubiquitin-like modifier inhibitor compound. In some embodiments, the method for treating a disease may further comprise administering one or more DNA-damaging therapy in combination with administration of the pharmaceutical composition.

Abstract: According to the embodiments described herein, a SUMOylation inhibitor compound comprising a singleton scaffold is provided. In some embodiments, a method for inhibiting a SUMOylation enzyme in a cell is provided. Such a method may include administering a SUMOylation inhibitor compound to the cell. In some aspects, the SUMOylation enzyme is SUMO E1 or SUMO E2. In some aspects, the method may be used to inhibit a cancer cell in vitro (e.g., grown in culture) or in vivo (e.g., as part of a tumor in a subject). In other embodiments, a method for treating a cancer, degenerative diseases and viral infection is provided. Such a method may include administering an effective amount of a pharmaceutical composition to a subject having the cancer. The pharmaceutical composition may include a singleton SUMOylation inhibitor compound.

Abstract: According to the embodiments described herein, a tricyclic SUMOylation inhibitor compound is provided. In some embodiments, a method for inhibiting a SUMOylation enzyme in a cell is provided. Such a method may include administering a SUMOylation inhibitor compound to the cell. In some aspects, the SUMOylation enzyme is SUMO E1 or SUMO E2. In some aspects, the method may be used to inhibit a cancer cell in vitro (e.g., grown in culture) or in vivo (e.g., as part of a tumor in a subject). In other embodiments, a method for treating a cancer, degenerative diseases and viral infection is provided. Such a method may include administering an effective amount of a pharmaceutical composition to a subject having the cancer. The pharmaceutical composition may include a SUMOylation inhibitor compound. In some embodiments, the method for treating a disease may further comprise administering one or more DNA-damaging therapy in combination with administration of the pharmaceutical composition.

Abstract: The present application relates to a Raman amplifier having an increased dynamic range, and particularly for laser pump sources and a method of pumping Raman fiber amplifiers over a greater dynamic range. In a multi-channel optical system, optical amplifiers must be able to provide gains over a large dynamic range, which is determined by the distribution of node-to-node distances in the network, as well as the number of channels. The present invention has found that the dynamic range of a Raman amplifier can be significantly increased by using pulse width modulation to pulse pump current at or near the minimum current stability threshold, in order to produce lower power output. The duty cycle of the pulsed current is selected to achieve a time-averaged operating condition, thus the time averaged pump power can be reduced in a linear fashion well below the capability of a continuous wave system.

Abstract: Systems and methods for permitting consumers to securely purchase, access, download and/or stream entertainment content such as musical and audio visual works, including a remote terminal or terminals. Consumers subscribe to the system and obtain a terminal or terminals. The terminals permit the subscribers to access the system to obtain content, either by downloading same to the terminal or by directly perceiving the content while streaming the content to the terminal. The invention prevents unauthorized copying, distribution and/or performance of protected works while at the same time eliminating the need for consumers to possess the tangible objects, e.g. CDS and DVDs, upon which detectable works normally reside. The software associated with the system regulates the transmission of content from the database(s) upon which it is stored, through a central server associated with the system, to the subscriber terminals for storage or immediate, i.e., “streaming”, playback.

Abstract: The invention relates to a method for automatic dynamic gain control in optical Raman amplifiers and an optical Raman amplifier adapted for the same. The present invention has found that in multiple pump Raman amplifiers a substantially linear relationship exists between total amplified signal power and pump power for each of different wavelength pumps, in order to maintain an original gain profile and gain levels for an optical link with a fully loaded channel configuration, in response to dropped channels. In accordance with the method, and an amplifier programmed to practice the method, a set of pump power values and signal level values required to maintain the characterized gain profile and gain levels for a plurality of channel loading configurations are pre-established for the each pump wavelength. A linear function from each set of pre-established values is derived for each pump wavelength.

Abstract: The invention relates to a method for automatic dynamic gain control in optical Raman amplifiers and an optical Raman amplifier adapted for the same. The present invention has found that in multiple pump Raman amplifiers a substantially linear relationship exists between total amplified signal power and pump power for each of different wavelength pumps, in order to maintain an original gain profile and gain levels for an optical link with a fully loaded channel configuration, in response to dropped channels. In accordance with the method, and an amplifier programmed to practice the method, a set of pump power values and signal level values required to maintain the characterized gain profile and gain levels for a plurality of channel loading configurations are pre-established for the each pump wavelength. A linear function from each set of pre-established values is derived for each pump wavelength.

Abstract: The present application relates to a Raman amplifier having an increased dynamic range, and particularly for laser pump sources and a method of pumping Raman fiber amplifiers over a greater dynamic range. In a multi-channel optical system, optical amplifiers must be able to provide gains over a large dynamic range, which is determined by the distribution of node-to-node distances in the network, as well as the number of channels. The present invention has found that the dynamic range of a Raman amplifier can be significantly increased by using pulse width modulation to pulse pump current at or near the minimum current stability threshold, in order to produce lower power output. The duty cycle of the pulsed current is selected to achieve a time-averaged operating condition, thus the time averaged pump power can be reduced in a linear fashion well below the capability of a continuous wave system.

Abstract: Systems and methods for permitting consumers to securely purchase, access, download and/or stream entertainment content such as musical and audio visual works, including a remote terminal or terminals. Consumers subscribe to the system and obtain a terminal or terminals. The terminals permit the subscribers to access the system to obtain content, either by downloading same to the terminal or by directly perceiving the content while streaming the content to the terminal. The invention prevents unauthorized copying, distribution and/or performance of protected works while at the same time eliminating the need for consumers to possess the tangible objects, e.g. CDS and DVDs, upon which detectable works normally reside. The software associated with the system regulates the transmission of content from the database(s) upon which it is stored, through a central server associated with the system, to the subscriber terminals for storage or immediate, i.e., “streaming”, playback.