Abstract: The present application relates to cyclosporine analogues and their use in medical applications, including as antiviral compounds and in gene therapy.

Abstract: A cyclosporin derivative which is a compound of formula (I), or a pharmaceutically acceptable salt thereof, for use in the treatment or prevention of a viral infection: wherein: A represents B represents methyl or ethyl, R2 represents ethyl or isopropyl, R4 represents —CH2CH(CH3)CH3, —CH2CH(CH3)CH2CH3, —CH(CH3)CH3 or —CH(CH3)CH2CH3, and either (a) one of R1 and R1* represents hydrogen and the other represents methyl, and R3 represents -L3-G3, or (b) one of R1 and R1* represents hydrogen and the other represents -L1-G1, and R3 represents H, wherein L1 and L3 represent a direct bond, a C1-C6 alkylene group or a C2-C6 alkenylene group; and G1 and G3 represent a hydrogen atom, a —COOR? group, or a phenyl moiety which is unsubstituted or substituted by one, two or three substituents selected from a halogen atom, a —COOR? group, a —CONR?R? group, a hydroxyl group, a C1-C6 alkyl group and a C1-C6 alkoxy group, wherein R? and R? are the same or different and represent hydrogen or a C1-C6 alkyl group,

Abstract: A cyclosporin derivative which is a compound of formula (I), or a pharmaceutically acceptable salt thereof, for use in the treatment or prevention of a viral infection: wherein: A represents (F(II)) or (F(III)) B represents methyl or ethyl, R2 represents ethyl or isopropyl, R4 represents —CH2CH(CH3)CH3, —CH2CH(CH3)CH2CH3, —CH(CH3)CH3 or —CH(CH3)CH2CH3, and either (a) one of R1 and R1* represents hydrogen and the other represents methyl, and R3 represents —L3-G3, or (b) one of R1 and R1* represents hydrogen and the other represents and R3 represents H, wherein L1 and L3 represent a direct bond, a C1-C6 alkylene group or a C2-C6 alkenylene group; and G1 and G3 represent a hydrogen atom, a —COOR? group, or a phenyl moiety which is unsubstituted or substituted by one, two or three substituents selected from a halogen atom, a —COOR? group, a —CONR?R? group, a hydroxyl group, a C1-C6 alkyl group and a C1-C6 alkoxy group, wherein R? and R? are the same or different and represent hydrogen or a C1-C6 alkyl group, prov