Abstract: Provided herein is a method of treating a PIM-1 and/or PIM-2 and/or PIM-3 kinase-mediated condition in a mammal, which comprises administering to said mammal a therapeutically effective amount of a compound of Formula I: in which A, B, R1, R1a, R2, R3, R4, R5, R6, and R7 have the meanings given in the specification.

Abstract: Provided herein is a method of treating a PIM-1 and/or PIM-2 and/or PIM-3 kinase-mediated condition in a mammal, which comprises administering to said mammal a therapeutically effective amount of a compound of Formula I: in which A, B, R1, R1a, R2, R3, R4, R5, R6, and R7 have the meanings given in the specification.

Abstract: Compounds of Formula (I), in which A, B, R1, R1a, R2, R3, R4, R5, R6, and R7 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of immune cell-associated diseases and disorders, such as inflammatory and autoimmune diseases.

Abstract: Compounds of Formula (I), in which A, B, R1, R1a, R2, R3, R4, R5, R6, and R7 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of immune cell-associated diseases and disorders, such as inflammatory and autoimmune diseases.

Abstract: Data traffic, through a data bridge that couples two entities, is monitored and logged in a data traffic log. If the size of the data traffic log does not change within a pre-determined period of time, the data bridge is automatically reset.

Abstract: The present invention provides a file monitoring approach that runs on bridge servers in an SNI environment, monitors a defined folder and detects the same file existing (by its file name persisting) for a predetermined interval period or longer. Optionally, the program can attempt to unlock the ticket corresponding to the inbound update. It also sends notification of the condition to bridge support. If the option to unlock the ticket is used, it reports on the success or failure of the attempt to unlock the ticket in the notification sent. One advantage of using this approach is to automatically detect when this condition is occurring to avoid bridge log space problems, possible customer calls to a helpdesk to request tickets be unlocked, and to notify bridge support. This approach helps to automate bridge support.

Abstract: A wireless node location mechanism that employs a differential signal strength metric to reduce the errors caused by variations in wireless node transmit power, errors in signal strength detection, and/or direction-dependent path loss. As opposed to using the absolute signal strength or power of an RF signal transmitted by a wireless node, implementations of the location mechanism compare the differences between signal strength values detected at various pairs of radio receivers to corresponding differences characterized in a model of the RF environment. One implementation searches for the locations in the model between each pair of radio receivers where their signal strength is different by an observed amount.

Abstract: A wireless node location mechanism that defines a search region to optimize the computations associated with estimating the location of a given wireless node. According to one implementation, a coverage map associated with each radio receiver that records signal strength data is defined out to a threshold signal strength level. Before computing the estimated location of a given wireless nodes, a search region is defined based on the intersection of the coverage maps associated with each radio receiver that detects the wireless node. Some implementations use information provided by the fact that certain radio receivers did not detect the wireless node to further optimize the location estimate. By defining a search region, which is a generally small area relative to the space encompassed by an entire RF environment, the present invention provides several advantages, such as reducing the processing time and/or power to compute estimated locations for wireless nodes.