Patents by Inventor Gregg Feigelson

Gregg Feigelson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes for preparing 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide
    Patent number: 11312699
    Abstract: Provided herein are processes for preparing 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: April 26, 2022
    Assignee: Celgene Corporation
    Inventors: Marie G. Beauchamps, Gregg Feigelson, Jianxin Han, Joshua Hansen, Mohit A. Kothare, Michael James Williams, Michael J. Zacuto, Weihong Zhang
  • PROCESSES FOR PREPARING 2-(4-CHLOROPHENYL)-N-((2-(2,6-DIOXOPIPERIDIN-3-YL)-1-OXOISOINDOLIN-5-YL)METHYL)-2,2-DIFLUOROACETAMIDE
    Publication number: 20210171493
    Abstract: Provided herein are processes for preparing 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide.
    Type: Application
    Filed: December 4, 2020
    Publication date: June 10, 2021
    Inventors: Marie G. Beauchamps, Gregg Feigelson, Jianxin Han, Joshua Hansen, Mohit A. Kothare, Michael James Williams, Michael J. Zacuto, Weihong Zhang
  • Crystalline forms of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile and methods of preparing the same
    Patent number: 8445496
    Abstract: This invention is directed to a crystalline 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile monohydrate having an x-ray diffraction pattern wherein 2? angles (°) of significant peaks are at about: 9.19, 11.48, 14.32, 19.16, 19.45, 20.46, 21.29, 22.33, 23.96, 24.95, 25.29, 25.84, 26.55, 27.61, and 29.51, and a transition temperature of about 109° C. to about 115° C.
    Type: Grant
    Filed: June 22, 2010
    Date of Patent: May 21, 2013
    Assignee: Wyeth LLC
    Inventors: Marc Sadler Tesconi, Gregg Feigelson, Henry Strong, Hong Wen
  • CRYSTALLINE FORMS OF 4-[(2,4-DICHLORO-5-METHOXYPHENYL)AMINO]-6-METHOXY-7-[3-(4-METHYL-1-PIPERAZINYL)PROPOXY]-3-QUINOLINECARBONITRILE AND METHODS OF PREPARING THE SAME
    Publication number: 20100324066
    Abstract: This invention is directed to a crystalline 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile monohydrate having an x-ray diffraction pattern wherein 2? angles (°) of significant peaks are at about: 9.19, 11.48, 14.32, 19.16, 19.45, 20.46, 21.29, 22.33, 23.96, 24.95, 25.29, 25.84, 26.55, 27.61, and 29.51, and a transition temperature of about 109° C. to about 115° C.
    Type: Application
    Filed: June 22, 2010
    Publication date: December 23, 2010
    Applicant: Wyeth LLC
    Inventors: Marc Sadler Tesconi, Gregg Feigelson, Henry Strong, Hong Wen
  • Crystalline forms of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile and methods of preparing the same
    Patent number: 7767678
    Abstract: This invention is directed to a crystalline 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile monohydrate having an x-ray diffraction pattern wherein 2? angles (°) of significant peaks are at about: 9.19, 11.48, 14.32, 19.16, 19.45, 20.46, 21.29, 22.33, 23.96, 24.95, 25.29, 25.84, 26.55, 27.61, and 29.51, and a transition temperature of about 109° C. to about 115° C.
    Type: Grant
    Filed: June 29, 2006
    Date of Patent: August 3, 2010
    Assignee: Wyeth LLC
    Inventors: Marc Sadler Tesconi, Gregg Feigelson, Henry Strong, Hong Wen
  • PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF HETEROCYCLIC SULFONAMIDE COMPOUNDS
    Publication number: 20090023930
    Abstract: Methods for preparing compound of formula (I) are described, wherein R1-R3 are defined herein, as are methods for preparing the intermediates formed therein. Also described are methods for enantioselectively preparing a chiral compound of the following structure, wherein R2 and R3 are defined herein.
    Type: Application
    Filed: July 14, 2008
    Publication date: January 22, 2009
    Applicant: Wyeth
    Inventors: Asaf Alimardanov, Antonia Nikitenko, Gregg Feigelson, John Potoski
  • Process for making chiral 1,4-disubstituted piperazines
    Publication number: 20080058543
    Abstract: A process for a stereoselective preparation of novel chiral nitrogen mustard derivatives useful in synthesizing optically active 1,4-disubstituted piperazines of formula: wherein R, Ar, and Q are defined as set forth herein, and intermediate compounds therefor. The 1,4-disubstituted piperazines act as 5HT1A receptor binding agents useful in the treatment of Central Nervous System (CNS) disorders.
    Type: Application
    Filed: August 8, 2007
    Publication date: March 6, 2008
    Inventors: Joseph Zeldis, Gregg Feigelson, Ivo Jirkovsky
  • Process for preparation of 4-amino-3-quinolinecarbonitriles
    Publication number: 20080033175
    Abstract: This invention discloses a process for the preparation of a 4-amino-3-quinolinecarbonitrile comprising combining an amine compound with a cyanoacetic acid and an acid catalyst to yield a cyanoacetamide; condensing the cyanoacetamide with an optionally up to tetra-substituted aniline in an alcoholic solvent and a trialkylorthoformate to yield a 3-amino-2-cyanoacrylamide; combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride in acetonitrile, butyronitrile, toluene or xylene, optionally in the presence of a catalyst to yield a 4-amino-3-quinolinecarbonitrile and also discloses a process for the preparation of a 7-amino-thieno[3,2-b]pyridine-6-carbonitrile comprising combining a disubstituted 3-amino thiophene with a cyanoacetamide and trialkylorthoformate in an alcoholic solvent to obtain a 3-amino-2-cyanoacrylamide; and combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride and acetonitrile, butyronitrile, toluene or xylene, optionally in the presence of a catalyst to yield a 7-amino-
    Type: Application
    Filed: October 5, 2007
    Publication date: February 7, 2008
    Applicant: Wyeth Holdings Corporation
    Inventors: Karen Sutherland, Gregg Feigelson, Diane Boschelli, David Blum, Henry Strong
  • Process for the Synthesis of Derivatives of 2,3-Dihydro-1,4-Dioxino-[2,3-f] Quinolines
    Publication number: 20070123705
    Abstract: Methods of preparing compounds of Formula I are provided.
    Type: Application
    Filed: December 4, 2006
    Publication date: May 31, 2007
    Applicant: Wyeth
    Inventors: Anita Chan, Timothy Curran, Silvio Iera, Warren Chew, John Sellstedt, Galina Vid, Gregg Feigelson, Zhixian Ding
  • Tetrahydroquinolines, synthesis thereof, and intermediates thereto
    Publication number: 20070088022
    Abstract: The present invention relates to methods for synthesizing compounds useful as 5HT2C agonists or partial agonists, derivatives thereof, and to intermediates thereto.
    Type: Application
    Filed: October 16, 2006
    Publication date: April 19, 2007
    Applicant: Wyeth
    Inventor: Gregg Feigelson
  • Diazepinoquinolines, synthesis thereof, and intermediates thereto
    Publication number: 20070027142
    Abstract: The present invention relates to methods for synthesizing compounds useful as 5HT2C agonists or partial agonists, derivatives thereof, and to intermediates thereto.
    Type: Application
    Filed: July 24, 2006
    Publication date: February 1, 2007
    Applicant: Wyeth
    Inventors: Sreenivasulu Megati, Anita Chan, Gregg Feigelson
  • Process for the synthesis of derivatives of 2,3-dihydro-1,4-dioxino-[2,3-f] quinoline
    Patent number: 7166723
    Abstract: Methods of preparing compounds of Formula I are provided.
    Type: Grant
    Filed: November 18, 2005
    Date of Patent: January 23, 2007
    Assignee: Wyeth
    Inventors: Anita Wai-Yin Chan, Timothy T. Curran, Silvio Iera, Warren Chew, John Hamilton Sellstedt, Galina Vid, Gregg Feigelson, Zhixian Ding
  • Crystalline forms of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile and methods of preparing the same
    Publication number: 20070015767
    Abstract: This invention is directed to a crystalline 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile monohydrate having an x-ray diffraction pattern wherein 2? angles (°) of significant peaks are at about: 9.19, 11.48, 14.32, 19.16, 19.45, 20.46, 21.29, 22.33, 23.96, 24.95, 25.29, 25.84, 26.55, 27.61, and 29.51, and a transition temperature of about 109° C. to about 115° C.
    Type: Application
    Filed: June 29, 2006
    Publication date: January 18, 2007
    Inventors: Marc Tesconi, Gregg Feigelson, Henry Strong, Hong Wen
  • Process for the synthesis of derivatives of 2, 3-dihydro-1, 4-dioxino- [2, 3-f] quinoline
    Patent number: 7038052
    Abstract: Methods of preparing compounds of Formula I are provided.
    Type: Grant
    Filed: December 12, 2003
    Date of Patent: May 2, 2006
    Assignee: Wyeth
    Inventors: Anita W. Chan, Timothy T. Curran, Silvio Iera, Warren Chew, John H. Sellstedt, Galina Vid, Gregg Feigelson, Zhixian Ding
  • Process for the synthesis of derivatives of 2,3-dihydro-1,4-dioxino-[2,3-f] quinoline
    Publication number: 20060074240
    Abstract: Methods of preparing compounds of Formula I are provided.
    Type: Application
    Filed: November 18, 2005
    Publication date: April 6, 2006
    Applicant: Wyeth
    Inventors: Anita Chan, Timothy Curran, Silvio Iera, Warren Chew, John Sellstedt, Galina Vid, Gregg Feigelson, Zhixian Ding
  • Process for making chiral 1,4-disubstituted piperazines
    Publication number: 20050228181
    Abstract: A process for a stereoselective preparation of novel chiral nitrogen mustard derivatives useful in synthesizing optically active 1,4-disubstituted piperazines of formula: wherein R, Ar, and Q are defined as set forth herein, and intermediate compounds therefor. The 1,4-disubstituted piperazines act as 5HT1A receptor binding agents useful in the treatment of Central Nervous System (CNS) disorders.
    Type: Application
    Filed: June 7, 2005
    Publication date: October 13, 2005
    Applicant: Wyeth
    Inventors: Joseph Zeldis, Gregg Feigelson, Ivo Jirkovsky
  • Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines
    Publication number: 20050070709
    Abstract: A process for making an N1-(2?-pyridyl)-1,2-alkanediamine sulfamic acid of formula II by reacting a compound of formula I with NH2R? wherein R and R? are as defined in the specification. The invention also includes the compound of formula II, and optical isomers thereof. The compound of formula II is an intermediate useful for making chiral piperazine derivatives which are active at the 5-HT1A receptor.
    Type: Application
    Filed: August 16, 2004
    Publication date: March 31, 2005
    Applicant: Wyeth
    Inventors: Anita Chan, Gregg Feigelson, Joseph Zeldis, Ivo Jirkovsky
  • Process for preparation of 4-amino-3-quinolinecarbonitriles
    Publication number: 20050043537
    Abstract: This invention discloses a process for the preparation of a 4-amino-3-quinolinecarbonitrile comprising combining an amine compound with a cyanoacetic acid and an acid catalyst to yield a cyanoacetamide; condensing the cyanoacetamide with an optionally up to tetra-substituted aniline in an alcoholic solvent and a trialkylorthoformate to yield a 3-amino-2-cyanoacrylamide; combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride in acetonitrile, butyronitrile, toluene or xylene, optionally in the presence of a catalyst to yield a 4-amino-3-quinolinecarbonitrile and also discloses a process for the preparation of a 7-amino-thieno[3,2-b]pyridine-6-carbonitrile comprising combining a disubstituted 3-amino thiophene with a cyanoacetamide and trialkylorthoformate in an alcoholic solvent to obtain a 3-amino-2-cyanoacrylamide; and combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride and acetonitrile, butyronitrile, toluene or xylene, optionally in the presence of a catalyst to yield a 7-amino-
    Type: Application
    Filed: August 16, 2004
    Publication date: February 24, 2005
    Applicant: Wyeth Holdings Corporation
    Inventors: Karen Sutherland, Gregg Feigelson, Diane Boschelli, David Blum, Henry Strong
  • Process for the synthesis of derivatives of 2, 3-dihydro-1, 4-dioxino- [2, 3-f] quinoline
    Publication number: 20040186123
    Abstract: Methods of preparing compounds of Formula I 1
    Type: Application
    Filed: December 12, 2003
    Publication date: September 23, 2004
    Applicant: Wyeth
    Inventors: Anita W. Chan, Timothy T. Curran, Silvio Iera, Warren Chew, John H. Sellstedt, Galina Vid, Gregg Feigelson, Zhixian Ding
  • Rake
    Patent number: D701097
    Type: Grant
    Filed: December 24, 2012
    Date of Patent: March 18, 2014
    Assignee: Innovative Garden Products, LLC
    Inventors: Rocco Petruzzelli, Gregg Feigelson