Abstract: The present invention relates i.a. to a CSFV (classical swine fever virus) comprising a substitution of proline to lysine at amino acid position 44 of the E2 protein and a substitution of threonine to aspartic acid at amino acid position 45 of the E2 protein. Further, the present invention provides an immunogenic composition comprising the CSFV of the present invention and the use of the immunogenic composition for reducing the incidence of or severity in an animal of one or more clinical signs associated with CSF. Moreover, the present invention provides a method of differentiating animals infected with CSFV from animals vaccinated with the immunogenic composition of the present invention.

Abstract: This invention relates to attenuated pestiviruses characterized in that their enzymatic activity residing in glycoprotein ERNS is inactivated, as well as methods of preparing, using and detecting these pestiviruses.

Abstract: The present invention relates to recombinant attenuated pestiviruses, in particular to recombinant attenuated CSFV, BVDV, or BDV, wherein said recombinant attenuated pestivirus does not produce a dimeric Erns glycoprotein. The present invention also relates to immunogenic compositions comprising such a pestivirus as well to a method of attenuating a pestivirus comprising the step of modifying the Erns glycoprotein by a deletion, insertion or substitution wherein such modification results in a non dimeric Erns glycoprotein.

Abstract: The invention belongs to the field of animal health and in particular Bovine Viral Diarrhea Virus (BVDV). The invention provides infectious BVDV clones and methods to produce said BVDV clones. The invention further relates to methods of attenuating said clones, attenuated BVDV clones and vaccines comprising said attenuated clones.

Abstract: The invention belongs to the field of animal health and in particular Bovine Viral Diarrhea Virus (BVDV). The invention provides infectious BVDV clones and methods to produce said BVDV clones. The invention further relates to methods of attenuating said clones, attenuated BVDV clones and vaccines comprising said attenuated clones.

Abstract: A medium and system for managing an external routine in a computer implemented database management system includes creating a first table for storing external routines in a data store coupled to the database management system. An external routine is stored in the first table so that the database management system is allowed to automatically manage any modification related to the external routine and to control access to the external routine such that administrative support is minimized.

Abstract: A method for managing an external routine in a computer implemented database management system includes creating a first table for storing external routines in a data store coupled to the database management system. An external routine is stored in the first table so that the database management system is allowed to automatically manage any modification related to the external routine and to control access to the external routine such that administrative support is minimized.

Abstract: The present invention relates to recombinant attenuated pestiviruses, in particular to recombinant attenuated CSFV, BVDV, or BDV, wherein said recombinant attenuated pestivirus does not produce a dimeric Ems glycoprotein. The present invention also relates to immunogenic compositions comprising such a pestivirus as well to a method of attenuating a pestivirus comprising the step of modifying the Ems glycoprotein by a deletion, insertion or substitution wherein such modification results in a non dimeric Ems glycoprotein.

Abstract: This invention relates to attenuated pestiviruses characterised in that their enzymatic activity residing in glycoprotein ERNS is inactivated, methods of preparing, using and detecting these.

Abstract: Attenuated pestiviruses, in particular attenuated BVDV, wherein at least one mutation is in the coding sequence for glycoprotein Erns and at least another mutation in the coding sequence for Npro which preferably leads to combined inactivation of the RNase activity residing in glycoprotein Erns in addition to the inactivation of the (hypothesized) immunomodulating activity residing in Npro. Methods for attenuating pestiviruses such as BVDV, nucleic acids encoding the pestiviruses, in particular BVDV, compositions and vaccines comprising the attenuated pestiviruses, in particular BVDV, of the invention.

Abstract: The present invention relates to combination vaccines for the prophylaxis and treatment of microbiological infections in cattle which comprise an attenuated bovine viral diarrhea virus (BVDV) for the prophylaxis and treatment of BVDV caused infections, and a further immunological active component for the prophylaxis and treatment of microbiological infections other than BVDV.

Abstract: This invention relates to attenuated pestiviruses characterised in that their enzymatic activity residing in glycoprotein ERNS is inactivated, methods of preparing, using and detecting these.

Abstract: A medium and system for managing an external routine in a computer implemented database management system includes creating a first table for storing external routines in a data store coupled to the database management system. An external routine is stored in the first table so that the database management system is allowed to automatically manage any modification related to the external routine and to control access to the external routine such that administrative support is minimized.

Abstract: A method for managing an external routine in a computer implemented database management system includes creating a first table for storing external routines in a data store coupled to the database management system. An external routine is stored in the first table so that the database management system is allowed to automatically manage any modification related to the external routine and to control access to the external routine such that administrative support is minimized.

Abstract: A system and method determine numerical representations for categorical data fields by taking advantage of the redundancy of the data records to allow automatic discovery of an order of the categories. A categorical data field is recoded by creating separate tables for each numerical data field occurring in the data records. The separate tables are sorted according to the numerical values of the respective data fields. The recoding of the categories is performed based on the average sort order of occurrences of the category in a specific sorted table. The standard deviation of the numerical codes provided by the categories is calculated for each of the separate recoding tables. The recoding table with the maximum standard deviation is selected as the recoding table to perform the recoding of the categories contained in the respective categorical data field of the data records.

Abstract: This invention relates to attenuated pestiviruses characterised in that their enzymatic activity residing in glycoprotein ERNS is inactivated, methods of preparing, using and detecting these.

Abstract: A method for managing an external routine in a computer implemented database management system includes creating a first table for storing external routines in a data store coupled to the database management system. An external routine is stored in the first table so that the database management system is allowed to automatically manage any modification related to the external routine and to control access to the external routine such that administrative support is minimized.

Abstract: The invention belongs to the field of animal health and in particular Bovine Viral Diarrhea Virus (BVDV). The invention provides infectious BVDV clones and methods to produce said BVDV clones. The invention further relates to methods of attenuating said clones, attenuated BVDV clones and vaccines comprising said attenuated clones.

Abstract: The invention belongs to the field of animal health and in particular Bovine Viral Diarrhea Virus (BVDV). The invention provides infectious BVDV clones and methods to produce said BVDV clones. The invention further relates to methods of attenuating said clones, attenuated BVDV clones and vaccines comprising said attenuated clones.

Abstract: A system and associated method for data mining prediction is presented according to which the user selects a database table by means of a graphical user interface. Some records in the table are complete, while other records are incomplete. A subset of records of the database table is determined wherein each record of the subset contains a data value in the column selected for prediction. This subset of records is used to generate a model by means of a data mining algorithm, such as linear regression, radial basis function, decision tree or neural network methods. The resulting model is then utilized to predict the empty data fields in the column. After completing the prediction, the predicted values are entered into the column for display to the user.