Abstract: Provided are methods and systems for inserting custom content. An example method can comprise receiving, at a first computing device, an insertion instruction over a first non-packet-switching protocol information stream. The method can also comprise querying, by the first computing device, a second computing device in response to receiving the insertion instruction. The method can further comprise receiving, at the first computing device, content over a packet-switching protocol information stream in response to querying the second computing device. The content can be customized for an end-user associated with the first computing device.

Abstract: Methods and systems for managing data are disclosed. One method can comprise storing first data locally relative to a user device and storing second data remotely relative to the user device. The first data and the second data can relate to the same content. The method can also comprise generating a manifest comprising location information relating to the first data and the second data and receiving a request for transmission of one or more of the first data and the second data based upon the manifest.

Abstract: An apparatus comprises a hopper housing, a first auger, a second auger, a dividing panel, and a motor. The hopper housing holds a bulk material, with the hopper housing including a first end at which the bulk material is added to the hopper housing and a second end comprising a discharge opening at which the bulk material exits the hopper housing. The first auger is disposed proximate to the discharge opening. The second auger is disposed between the first end of the hopper housing and the first auger. The dividing panel is disposed between the first auger and the second auger and the dividing panel is coupled to the hopper housing at the first side thereof and forming a panel opening between the hopper housing and the second side thereof. The motor rotates the first auger and the second auger to move the bulk material into the discharge opening.

Abstract: A thermal management system for a computing device often includes one or more internal heat pipes and conductive structures to move heat from one or more heat-generating components within the computing device to a heat exchanger. For an air-cooled device, one or more exhaust fans blow air across the heat exchanger to transfer heat from the heat exchanger to the air before it is exhausted out of the computing device. While operation of the exhaust fans may be necessary to maintain device temperature below one or more thresholds, exhaust fan operation may be optimized to maximize the user experience. The presently disclosed technology applies distinct exhaust fan speed and/or direction profiles for each of one or more exhaust fans within the computing device to maximize the user experience, particularly to reduce or avoid blowing hot air at the user's hand.

Abstract: Nucleic acid aptamers having a high binding affinity and specificity for malodorous molecules and the use of such aptamers to reduce the intensity of the undesirable smells in personal care compositions.

Abstract: An aptamer composition is disclosed which has one or more oligonucleotides that include at least one of deoxyribonucleotides, ribonucleotides, derivatives of deoxyribonucleotides, derivatives of ribonucleotides, or mixtures thereof. The aptamer composition has a binding affinity for one or more cellular membrane glycoproteins selected from the group consisting of: intercellular adhesion molecule 1 (ICAM-1), low-density lipoprotein receptor (LDLR) family members, and cadherin-related family member 3 (CDHR3), preferably intercellular adhesion molecule 1 (ICAM-1), and is configured to reduce the binding of one or more human rhinoviruses to the intercellular adhesion molecule 1 (ICAM-1).

Abstract: The present disclosure provides immune cells genetically modified to produce two antigen-triggered polypeptides, each recognizing a different cell surface antigen, wherein the two different cell surface antigens employed are selected from those pairs described herein. The present disclosure further provides systems comprising two antigen-triggered polypeptides (or nucleic acids encoding same), each recognizing a different cell surface antigen, wherein the two different cell surface antigens employed are selected from those pairs described herein. Also provided are method of killing a target cancer cell, using the described genetically modified immune cells and/or systems. The present disclosure also provides polyspecific-immune inducing polypeptides including first and second antigen binding domains specific for first and second antigens, respectively, present on the surface of a target cancer cell.

Abstract: A content delivery network may provide content items to requesting devices using a popularity-based distribution hierarchy. A central analysis system may determine popularity data for a content item stored in a first caching device. The central analysis system may determine that a change in the popularity data is beyond a threshold value. The central analysis system may then transmit an instruction to move the content item from the first caching device to a second caching device in a different tier of caching devices than the first caching device. The central analysis system may update a content index to indicate that the content item has been moved to the second caching device. A user device may be redirected to request the content item directly from the second caching device.

Abstract: A natural language understanding method begins with a radiological report text containing clinical findings. Errors in the text are corrected by analyzing character-level optical transformation costs weighted by a frequency analysis over a corpus corresponding to the report text. For each word within the report text, a word embedding is obtained, character-level embeddings are determined, and the word and character-level embeddings are concatenated to a neural network which generates a plurality of NER tagged spans for the report text. A set of linked relationships are calculated for the NER tagged spans by generating masked text sequences based on the report text and determined pairs of potentially linked NER spans. A dense adjacency matrix is calculated based on attention weights obtained from providing the one or more masked text sequences to a Transformer deep learning network, and graph convolutions are then performed over the calculated dense adjacency matrix.

Abstract: Methods and systems for providing content are disclosed. One method can comprise receiving a request for content comprising at least a first segment. The method can also comprise determining an expiration condition of the first segment, and replacing the first segment with a second segment based on the expiration condition. The method can also comprise providing the second segment to a user or a device.

Abstract: A system includes a multiplexer, an input/output (I/O) pin, a logic circuit, and a control register. The multiplexer has multiple inputs, an output, and a selection input. The logic circuit is coupled between the multiplexer and the I/O pin. The logic circuit has a first input. The control register includes first and second bit fields corresponding to the I/O pin. The first bit field is coupled to the selection input of the multiplexer, and the second bit field is coupled to the first input of the logic circuit.

Abstract: An aptamer composition is disclosed which has one or more oligonucleotides that include at least one of deoxyribonucleotides, ribonucleotides, derivatives of deoxyribonucleotides, derivatives of ribonucleotides, or mixtures thereof. The aptamer composition has a binding affinity for one or more cellular membrane glycoproteins selected from the group consisting of: intercellular adhesion molecule 1 (ICAM-1), low-density lipoprotein receptor (LDLR) family members, and cadherin-related family member 3 (CDHR3), preferably intercellular adhesion molecule 1 (ICAM-1), and is configured to reduce the binding of one or more human rhinoviruses to the intercellular adhesion molecule 1 (ICAM-1).

Abstract: A method of adaptively controlling the distribution of power supplied by a charger of an electronic device between an energy storage device and one or more hardware elements is provided. The method includes determining whether current communicated between the charger of the electronic device and the energy storage device satisfies a charging condition, the charging condition based on one or more of a direction of the current communicated and a magnitude of the current communicated, determining whether consumed system power consumed by the hardware elements satisfies a system power condition based on a determined system power limit, and adjusting power consumption of the one or more hardware elements of the electronic device to consume a different consumed system power within a predefined range of system power limits, based at least in part on satisfaction of the charging condition and satisfaction of the power supply condition.

Abstract: A downhole acoustic stimulation tool comprises: a sealed chamber containing a liquid; a pair of electrodes located in the chamber; at least one transducer arranged to generate an acoustic field between the electrodes thereby inducing cavitation in a volume of the liquid between the electrodes; and at least one capacitor configured to apply a pulse voltage across the electrodes when discharged, thereby causing the cavitating volume of liquid to form a plasma which collapses to form a shockwave. The at least one transducer constitutes a first energy source, and the at least one capacitor back and electrodes constitute a second energy source. Alternative forms and arrangements of the first and second energy sources are also disclosed.

Abstract: A treadmill has a front or rear set of pulleys and a looped running belt. The pulleys rotate with the movement of the belt, e.g., when a user walks, jogs, or runs on the treadmill. The pulleys are mounted on a rotating roller tube so that the roller tube rotates with the pulleys. The roller tube is mounted on a stationary shaft using bearings on each side and a one-way device that allows the pulleys to rotate in one direction. The rotation direction corresponds to the movement of the top of the belt from the front to the rear of the treadmill. The one-way device prevents the pulleys from rotating in the opposite direction, preventing the top of the belt from moving from the rear of the treadmill to the front. The one-way device may be a sprag clutch. The treadmill may be a motor-less, curved treadmill.

Abstract: An aptamer composition is disclosed which has one or more oligonucleotides that include at least one of deoxyribonucleotides, ribonucleotides, derivatives of deoxyribonucleotides, derivatives of ribonucleotides, or mixtures thereof. The aptamer composition has a binding affinity for one or more cellular membrane glycoproteins selected from the group consisting of: intercellular adhesion molecule 1 (ICAM-1), low-density lipoprotein receptor (LDLR) family members, and cadherin-related family member 3 (CDHR3), preferably intercellular adhesion molecule 1 (ICAM-1), and is configured to reduce the binding of one or more human rhinoviruses to the intercellular adhesion molecule 1 (ICAM-1).

Abstract: An aptamer composition is disclosed which has one or more oligonucleotides that include at least one of deoxyribonucleotides, ribonucleotides, derivatives of deoxyribonucleotides, derivatives of ribonucleotides, or mixtures thereof. The aptamer composition has a binding affinity for one or more cellular membrane glycoproteins selected from the group consisting of: intercellular adhesion molecule 1 (ICAM-1), low-density lipoprotein receptor (LDLR) family members, and cadherin-related family member 3 (CDHR3), preferably intercellular adhesion molecule 1 (ICAM-1), and is configured to reduce the binding of one or more human rhinoviruses to the intercellular adhesion molecule 1 (ICAM-1).

Abstract: Cartridge loaders for fluid mixture dispensing systems are disclosed. One disclosed fluid mixture dispensing system comprises an interface surface, a cartridge receiver carriage, and an actuator configured to depress the cartridge receiver carriage towards the interface surface to load a cartridge. The fluid mixture dispensing system is configured to apply continuous downward pressure on the cartridge towards the interface surface when the cartridge is loaded and is in contact with the interface surface.

Abstract: Cartridge loaders for fluid mixture dispensing systems are disclosed. One disclosed fluid mixture dispensing system comprises an interface surface, a cartridge receiver carriage, and an actuator configured to depress the cartridge receiver carriage towards the interface surface to load a cartridge. The fluid mixture dispensing system is configured to apply continuous downward pressure on the cartridge towards the interface surface when the cartridge is loaded and is in contact with the interface surface.

Abstract: A refinery spacecraft comprises a hub section defining a longitudinal axis, an excavator segment to convey material into the hub section, first, second and third rotary ring segments rotatable about the hub section with adjustable speed and direction, each rotary ring segments comprising three modules configured to carry out refining or storage processes and wherein two of the three modules in each rotary ring segment have adjustable angular positions relative to the longitudinal axis. Methods of collecting and refining substances from an asteroid, derelict orbiting spacecraft or other space junk, can comprise attaching a refining spacecraft to an asteroid, extracting material from the asteroid, transferring material into a refining hub, transferring material to refining rings orbiting the refining hub, and controlling orbiting of the refining rings about the hub to establish and maintain angular momentum of the refining spacecraft at a stable condition.