Patents by Inventor Gregory A. Dasch

Gregory A. Dasch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20110045011
    Abstract: A recombinant, refolded non-fusion polypeptide expressed from a truncated r56 gene of the causative agent of scrub typhus, Orientia tsutsugamushi for the Karp, Kato and Gilliam strains has been produced. The invention is useful for detecting prior exposure to scrub typhus, screening for and/or identification of at least one infectious strain-similarity (i.e. a Karp-like, Kato-like or Gilliam-like strain) based on its strength of reaction toward a truncated protein and as a component in vaccine formulation sand production of immune globulins for passive prophylaxis and immunity in subjects.
    Type: Application
    Filed: October 29, 2010
    Publication date: February 24, 2011
    Inventors: Wei-Mei Ching, Daryl J. Kelly, Gregory A. Dasch
  • Patent number: 7846675
    Abstract: A recombinant, refolded non-fusion polypeptide expressed from a truncated r56 gene of the causative agent of scrub typhus, Orientia tsutsugamushi for the Karp, Kato and Gilliam strains has been produced. The invention is useful for detecting prior exposure to scrub typhus, screening for and/or identification of at least one infectious strain-similarity (i.e. a Karp-like, Kato-like or Gilliam-like strain) based on its strength of reaction toward a truncated protein and as a component in vaccine formulation sand production of immune globulins for passive prophylaxis and immunity in subjects.
    Type: Grant
    Filed: December 27, 2007
    Date of Patent: December 7, 2010
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Wei-Mei Ching, Daryl J. Kelly, Gregory A. Dasch
  • Patent number: 7638130
    Abstract: A recombinant, refolded non-fusion polypeptide expressed from a truncated r56 gene of the causative agent of scrub typhus, Orientia tsutsugamushi for the Karp, Kato and Gilliam strains has been produced. The invention is useful for detecting prior exposure to scrub typhus, screening for and/or identification of at least one infectious strain-similarity (i.e. a Karp-like, Kato-like or Gilliam-like strain) based on its strength of reaction toward a truncated protein and as a component in vaccine formulation sand production of immune globulins for passive prophylaxis and immunity in subjects.
    Type: Grant
    Filed: December 27, 2007
    Date of Patent: December 29, 2009
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Wei-Mei Ching, Daryl J. Kelly, Gregory A. Dasch
  • Publication number: 20090311722
    Abstract: A recombinant, refolded non-fusion polypeptide expressed from a truncated r56 gene of the causative agent of scrub typhus, Orientia tsutsugamushi for the Karp, Kato and Gilliam strains has been produced. The invention is useful for detecting prior exposure to scrub typhus, screening for and/or identification of at least one infectious strain-similarity (i.e. a Karp-like, Kato-like or Gilliam-like strain) based on its strength of reaction toward a truncated protein and as a component in vaccine formulation sand production of immune globulins for passive prophylaxis and immunity in subjects.
    Type: Application
    Filed: December 27, 2007
    Publication date: December 17, 2009
    Inventors: Wei-Mei Ching, Daryl J. Kelly, Gregory A. Dasch
  • Publication number: 20080279881
    Abstract: A recombinant, refolded non-fusion polypeptide expressed from a truncated r56 gene of the causative agent of scrub typhus, Orientia tsutsugamushi for the Karp, Kato and Gilliam strains has been produced. The invention is useful for detecting prior exposure to scrub typhus, screening for and/or identification of at least one infectious strain-similarity (i.e. a Karp-like, Kato-like or Gilliam-like strain) based on its strength of reaction toward a truncated protein and as a component in vaccine formulation sand production of immune globulins for passive prophylaxis and immunity in subjects.
    Type: Application
    Filed: December 27, 2007
    Publication date: November 13, 2008
    Inventors: Wei-Mei Ching, Daryl J. Kelly, Gregory A. Dasch
  • Patent number: 7335477
    Abstract: A recombinant, refolded non-fusion polypeptide expressed from a truncated r56 gene of the causative agent of scrub typhus, Orientia tsutsugamushi for the Karp, Kato and Gilliam strains has been produced. The invention is useful for detecting prior exposure to scrub typhus, screening for and/or identification of at least one infectious strain-similarity (i.e. a Karp-like, Kato-like or Gilliam-like strain) based on its strength of reaction toward a truncated protein and as a component in vaccine formulations and production of immune globulins for passive prophylaxis and immunity in subjects.
    Type: Grant
    Filed: April 12, 2002
    Date of Patent: February 26, 2008
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Wei-Mei Ching, Daryl J. Kelly, Gregory A. Dasch
  • Patent number: 6699674
    Abstract: A recombinant, refolded non-fusion polypeptide expressed from a truncated r56 gene of the causative agent of scrub typhus, Orientia tsutsugamushi. The invention is useful for detecting prior exposure to scrub typhus and as a component in vaccine formulations.
    Type: Grant
    Filed: June 14, 2002
    Date of Patent: March 2, 2004
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Wei-Me Ching, Daryl J. Kelly, Gregory A. Dasch
  • Publication number: 20030185837
    Abstract: A recombinant, refolded non-fusion polypeptide expressed from a truncated r56 gene of the causative agent of scrub typhus, Orientia tsutsugamushi. The invention is useful for detecting prior exposure to scrub typhus and as a component in vaccine formulations.
    Type: Application
    Filed: June 14, 2002
    Publication date: October 2, 2003
    Applicant: The United States of America as Represented by the Secretary of the Navy
    Inventors: Wei-Me Ching, Daryl J. Kelly, Gregory A. Dasch
  • Publication number: 20030165523
    Abstract: A recombinant, refolded non-fusion polypeptide expressed from a truncated r56 gene of the causative agent of scrub typhus, Orientia tsutsugamushi for the Karp, Kato and Gilliam strains has been produced. The invention is useful for detecting prior exposure to scrub typhus, screening for and/or identification of at least one infectious strain-similarity (i.e. a Karp-like, Kato-like or Gilliam-like strain) based on its strength of reaction toward a truncated protein and as a component in vaccine formulations and production of immune globulins for passive prophylaxis and immunity in subjects.
    Type: Application
    Filed: April 12, 2002
    Publication date: September 4, 2003
    Inventors: Wei-Mei Ching, Daryl J. Kelly, Gregory A. Dasch
  • Patent number: 6482415
    Abstract: A recombinant, refolded non-fusion polypeptide expressed from a truncated r56 gene of the causative agent of scrub typhus, Orientia tsutsugamushi. The invention is useful for detecting prior exposure to scrub typhus and as a component in vaccine formulations.
    Type: Grant
    Filed: December 22, 1998
    Date of Patent: November 19, 2002
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Wei-Mei Ching, Daryl J. Kelly, Gregory A. Dasch
  • Patent number: 5783441
    Abstract: All or part of the DNA sequence of the gene which encodes the S-layer protein of R. prowazekii as illustrated in Sequence ID No. 1 as well as a truncated identical piece of this gene in R. typhi as well as the 5' and 3' noncoding regions can be used for vaccination against typhus and spotted fever rickettsial infection or to diagnose the diseases caused by these bacteria. The invention is also accomplished by the deduced amino acid sequence of the S-layer protein of R. prowazekii derived from the DNA sequence of the encoding gene. Further, the invention includes the peptide or protein products based on all or parts of this gene.
    Type: Grant
    Filed: December 20, 1993
    Date of Patent: July 21, 1998
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Mitchell Carl, Michael E. Dobson, Wei-Mei Ching, Gregory A. Dasch