Abstract: The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.

Abstract: A system for correlating crime incidents with the location of a subject in which crime incident data containing information about the location and time of at least one crime and subject location data containing information about the locations at various times of a plurality of subjects are provided to a correlation database of a computer, whereupon the correlation computer correlates the crime incident data and the subject location data to determine if each of said subjects are likely suspects of said crime based upon whether each of the subjects were proximate to the location of the crime at the time of the crime.