Abstract: Compounds are provided according to Formula (I), and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein A, R1, and R5 are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.

Abstract: A system for railroad directive management is presented. The system can receive a myriad of data related to a directive, track segments, and/or vehicle events on the track and/or track segments. Vehicle- and/or event-specific data can be compared with one or more thresholds, including force thresholds, temporal thresholds, environmental thresholds, and/or event thresholds to determine whether and what kind of directive modification should be instantiated. Specialized algorithms can be implemented to trace vehicle paths along the track to determine whether directive-related segments are traversed, and specialized clustering algorithms can be utilized to cluster data unique to a particular segment on a per-segment basis. The system can be integrated with existing track infrastructure and can further generate alerts to notify coupled systems and/or personnel of directives and/or modification thereof.

Abstract: Reliability monitoring can be performed for compute instances in a cluster with auto-scaling capability. Such monitoring can analyze state information for various instances, such as spot instances, to determine when an interruption or termination is to occur. An impact assessor can determine the impact on performance due to any such interruption or termination, and if necessary to maintain at least a minimum level of performance then an action performer can obtain additional or alternate instances, which may be of a different type, to make up for lost capacity. Any tasks being performed can be migrated to the newly-allocated instances without any failures or significant impact on performance, and the previously-utilized instances can be released corresponding to the termination or interruption.

Abstract: Embodiments of the disclosure provide for a system and method for determining a circuit breaker position in a power distribution/load center. In one embodiment, the load center includes a plurality of circuit breakers. Each circuit breaker includes a base and a plurality of contact components coupled to the base. In that regard, an activation of a combination of the contact components indicates a position of the circuit breaker within the load center. The activation of the combination indicates that one or more of the contact components is in contact with one or more pegs coupled to the load center. When this occurs, a data transceiver coupled to each of the contact components transmits a data signal. The data signal includes a plurality of data bits, where each data bit indicates whether a corresponding contact component of the combination is activated or not activated.

Abstract: Embodiments of the disclosure provide for a system and method for determining a circuit breaker position in a power distribution/load center. In one embodiment, the load center includes a plurality of circuit breakers. Each circuit breaker includes a base and a plurality of contact components coupled to the base. In that regard, an activation of a combination of the contact components indicates a position of the circuit breaker within the load center. The activation of the combination indicates that one or more of the contact components is in contact with one or more pegs coupled to the load center. When this occurs, a data transceiver coupled to each of the contact components transmits a data signal. The data signal includes a plurality of data bits, where each data bit indicates whether a corresponding contact component of the combination is activated or not activated.

Abstract: A system for railroad directive management is presented. The system can receive a myriad of data related to a directive, track segments, and/or vehicle events on the track and/or track segments. Vehicle- and/or event-specific data can be compared with one or more thresholds, including force thresholds, temporal thresholds, environmental thresholds, and/or event thresholds to determine whether and what kind of directive modification should be instantiated. Specialized algorithms can be implemented to trace vehicle paths along the track to determine whether directive-related segments are traversed, and specialized clustering algorithms can be utilized to cluster data unique to a particular segment on a per-segment basis. The system can be integrated with existing track infrastructure and can further generate alerts to notify coupled systems and/or personnel of directives and/or modification thereof.

Abstract: A system for railroad directive management is presented. The system can receive a myriad of data related to a directive, track segments, and/or vehicle events on the track and/or track segments. Vehicle- and/or event-specific data can be compared with one or more thresholds, including force thresholds, temporal thresholds, environmental thresholds, and/or event thresholds to determine whether and what kind of directive modification should be instantiated. Specialized algorithms can be implemented to trace vehicle paths along the track to determine whether directive-related segments are traversed, and specialized clustering algorithms can be utilized to cluster data unique to a particular segment on a per-segment basis. The system can be integrated with existing track infrastructure and can further generate alerts to notify coupled systems and/or personnel of directives and/or modification thereof.

Abstract: Embodiments of the disclosure provide for a fast device installation and replacement (DI&R) service in a network while simultaneously providing confidentiality and integrity protection for sensitive device data. In one embodiment, this protection is provided by using certain characterization data associated with each device in a network to generate a passphrase. This passphrase can be related to the topology of the devices. In one embodiment, the passphrase is a concatenation of certain device characterization data with respect to the topology. In embodiments, the concatenation includes arranging the characterization data based on an order of each device with respect to the topology. Cryptographic keys are derived based on the passphrase. The cryptographic keys are used to automatically encrypt and decrypt the sensitive device data without user intervention.

Abstract: An augmented reality device. The device includes an integrated lens system having a field of view (FOV). The lens system includes a reflective layer, a transparent substrate layer, an external light control layer, and an anti-reflective layer. The device also includes a display device configured to present an image on an interior surface of the integrated lens system.

Abstract: Embodiments of the disclosure provide for a system and method for determining a circuit breaker position in a power distribution/load center. In one embodiment, the load center includes a plurality of circuit breakers. Each circuit breaker includes a base and a plurality of contact components coupled to the base. In that regard, an activation of a combination of the contact components indicates a position of the circuit breaker within the load center. The activation of the combination indicates that one or more of the contact components is in contact with one or more pegs coupled to the load center. When this occurs, a data transceiver coupled to each of the contact components transmits a data signal. The data signal includes a plurality of data bits, where each data bit indicates whether a corresponding contact component of the combination is activated or not activated.

Abstract: A head-mounted display (HMD) apparatus comprising at least one optical system, each optical system comprising a lens having a reflective optical surface and an HMD device associated with and distanced from the reflective optical surface. The HMD device comprises a substrate having horizontal and/or vertical convex curvatures having a curved geometric profile which continuously curves with smooth transitions in horizontal and/or vertical dimensions. The curved profile is dimensioned to curve around a temple of a wearer and extend in a direction toward an ear of a wearer. The substrate comprising a plurality of pixel elements arranged along the horizontal convex curvature and being controlled to selectively radiate light representative of computer-generated content (CGC) to the associated reflective optical surface such that those selected pixel elements for display emanate rays of the light for subsequent reflection from the reflective optical surface toward a respective one eye of the wearer.

Abstract: Embodiments of the disclosure provide for a system and method for determining a circuit breaker position in a power distribution/load center. In one embodiment, the load center includes a plurality of circuit breakers. Each circuit breaker includes a base and a plurality of contact components coupled to the base. In that regard, an activation of a combination of the contact components indicates a position of the circuit breaker within the load center. The activation of the combination indicates that one or more of the contact components is in contact with one or more pegs coupled to the load center. When this occurs, a data transceiver coupled to each of the contact components transmits a data signal. The data signal includes a plurality of data bits, where each data bit indicates whether a corresponding contact component of the combination is activated or not activated.

Abstract: Embodiments of the disclosure provide for a system and method for determining a circuit breaker position in a power distribution/load center. In one embodiment, the load center includes a plurality of circuit breakers. Each circuit breaker includes a base and a plurality of contact components coupled to the base. In that regard, an activation of a combination of the contact components indicates a position of the circuit breaker within the load center. The activation of the combination indicates that one or more of the contact components is in contact with one or more pegs coupled to the load center. When this occurs, a data transceiver coupled to each of the contact components transmits a data signal. The data signal includes a plurality of data bits, where each data bit indicates whether a corresponding contact component of the combination is activated or not activated.

Abstract: A spout for a paint container having a retracted position with the spout resting within the volume of the container and an extended position with a portion of the spout extending through the top opening of the can. When retracted, the can is sealable with a friction fit lid in the rim channel, as is commonly used with paint cans, or the assembly may include a collar mountable within a rim channel that accommodates the traditional paint can lid. Regardless of the embodiment, the spout is held within the can proximate to the rim and can quickly move between the extended and retracted positions with a flange on the lower portion of the spout sealing against the annular collar in the extended position and tabs on the top portion of the spout holding the spout near the rim when retracted.

Abstract: Embodiments of the disclosure provide for a fast device installation and replacement (DI&R) service in a network while simultaneously providing confidentiality and integrity protection for sensitive device data. In one embodiment, this protection is provided by using certain characterization data associated with each device in a network to generate a passphrase. This passphrase can be related to the topology of the devices. In one embodiment, the passphrase is a concatenation of certain device characterization data with respect to the topology. In embodiments, the concatenation includes arranging the characterization data based on an order of each device with respect to the topology. Cryptographic keys are derived based on the passphrase. The cryptographic keys are used to automatically encrypt and decrypt the sensitive device data without user intervention.

Abstract: An optical system that includes a lens element and a lens element holder. The optical system also includes a display device holder that is configured to hold a display device having a single light-emitting panel. The lens element includes a right-eye reflective surface and a left-eye reflective surface. The right-eye reflective surface includes a first plurality of different surface elements oriented to reflect and collimate light from corresponding different regions of a first portion of the light-emitting panel toward a predetermined right-eye location, and the left-eye reflective surface includes a second plurality of different surface elements oriented to reflect and collimate light from corresponding different regions of a second portion of the light-emitting panel toward a predetermined left-eye location.

Abstract: Multiple-reflector ultrawide field of view (UWFOV) systems and methods are provided. In one embodiment, a head-wearable display device includes a frame, a narrow-beam light source fixed with respect to the frame, a UWFOV reflective surface fixed with respect to the frame, and a diverging reflective surface fixed with respect to the frame that is configured to receive light emitted from the narrow-beam light source and reflect the light toward the UWFOV reflective surface to spread the light completely across the UWFOV reflective surface.

Abstract: A head-up display (HUD) apparatus is provided. The HUD apparatus includes a display holder configured to hold a single planar multiple-pixel display. The HUD apparatus also includes a single reflective and transmissive lens that is configured to reflect an image from the planar multiple-pixel display toward a predetermined location of a user. The reflective and transmissive lens is further configured to at least partially collimate light from the planar multiple-pixel display to focus the image at a distance in front of the reflective and transmissive lens for each eye of two eyes of the user.

Abstract: A method comprising detecting, by a processor, an optical sight of a device in range of a lens of a head mounted display (HMD) apparatus. The lens has an HMD field of view (H-FOV) of a real-world view. The method comprises determining, by the processor, a magnification factor of a sight field of view (S-FOV) for the detected sight. The method includes displaying, by a display device of the HMD apparatus, computer generated data (CGD) in the S-FOV relative to a magnification level according to the magnification factor of the S-FOV of the real-world view while looking through the sight. A system and computer readable medium are also provided.

Abstract: Head-mounted displays (100) are disclosed which include a frame (107), an image display system (110) supported by the frame (107), and a Fresnel lens system (115) supported by the frame (107). The HMD (100) can employ a reflective optical surface, e.g., a free-space, ultra-wide angle, reflective optical surface (a FS/UWA/RO surface) (120), supported by the frame (107), with the Fresnel lens system (115) being located between the image display system (110) and the reflective optical surface (120). The Fresnel lens system (115) can include at least one curved Fresnel lens element (820). Fresnel lens elements (30) for use in HMDs are also disclosed which have facets (31) separated by edges (32) which lie along radial lines (33) which during use of the HMD pass through a center of rotation (34) of a nominal user's eye (35) or through the center of the eye's lens (36) or are normal to the surface of the eye's cornea.