Patents by Inventor Gregory A. Lizee

Gregory A. Lizee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • T-CELL RECEPTORS TARGETING EGFR AND METHODS OF USE THEREOF
    Publication number: 20260216244
    Abstract: The present disclosure provides T-cell receptors comprising an antigen binding variable region that specifically binds an antigenic peptide derived from EGFR L858R. The present disclosure, further provides activated or engineered T-cells comprising the T-cell receptors of the disclosure, and methods of making and using these T-cell receptors. Aspects of the disclosure further relate to a polypeptide comprising an antigen binding variable region comprising a CDR3 region of the disclosure.
    Type: Application
    Filed: January 31, 2024
    Publication date: July 30, 2026
    Applicant: Board of Regents, The University of Texas System
    Inventors: Alexandre Reuben, Minying Zhang, John Victor Heymach, Gregory A. Lizee, Peixin Jiang
  • T CELL RECEPTORS TARGETING THE HIGHLY PREVALENT KRAS G12V MUTATION ON HLA-A*03:01 IN LUNG CANCER
    Publication number: 20260216333
    Abstract: The present disclosure is directed to recombinant T-cell Receptors (TCRs) that binds Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) protein comprising a G12V mutation presented on a human leucocyte antigen-A (HLA-A)*03:01, polynucleotides encoding such TCRs, engineered T-cells comprising such TCRs, and methods of using the same.
    Type: Application
    Filed: January 4, 2024
    Publication date: July 30, 2026
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Alexandre REUBEN, Minying ZHANG, John Victor HEYMACH, Gregory A. LIZEE, Peixin JIANG