Abstract: An improved fluidic spray device that includes: (a) a base having boundary surfaces including top, bottom and side edge surfaces, (b) a plurality of projections extending from a base boundary surface chosen from the group consisting of its top and bottom surfaces, wherein these projections are configured and spaced so as to provide the interior geometry of the flow passages for a fluidic circuit having a power nozzle and an interaction region located downstream of the power nozzle, and (c) wherein the flow passages that are proximate the base edges having no sidewalls to form edge boundaries for these flow passages.

Abstract: The present invention relates to the delivery of drug, peptide and protein pharmaceuticals using a biotin-mediated uptake system. More particularly the invention relates to the amplification of active substance delivery with the biotin uptake system using a biotin-active substance-polymer conjugate or a biotin-nanoparticle conjugate. The invention also relates to processes for preparing the conjugates, pharmaceutical and diagnostic compositions containing same and methods of diagnosis and treatment involving the conjugates.

Abstract: For those spray applications that use a fluidic oscillator of the type that generates a spray by having a pressurized liquid flow through the oscillator and exhaust into a surrounding environment, and where such an oscillator has a boundary surface which has fabricated into it a channel in the form of what is referred to herein as fluidic circuit, an improved enclosure for this oscillator includes: a body having an interior and an exterior surface, wherein a portion of this interior surface is configured to attach to the oscillator boundary surface so as to form with the oscillator's channel an enclosed pathway through which the to-be-sprayed liquid may flow, and wherein a segment of this interior surface is configured so as to yield specified properties of the resulting spray.

Abstract: A fluidic oscillator suitable for use at colder temperatures for generating an exhaust flow in the form of an oscillating spray of fluid droplets has an inlet for pressurized fluid, a pair of power nozzles configured to accelerate the movement of the pressurized fluid, a fluid pathway that connects and allows for the flow of pressurized fluid between its inlet and the power nozzles, an interaction chamber which is attached to the nozzles and receives the flow from the nozzles, a fluid outlet from which the spray exhausts from the interaction chamber, and a means for increasing the instability of the flow from the power nozzles, with this means being situated in a location chosen from the group consisting of a location within the fluid pathway or proximate the power nozzles. In a first preferred embodiment, the flow instability generating means comprises a protrusion that extends inward from each side of the fluid pathway so as to cause a flow separation region downstream of the protrusions.

Abstract: A fluidic insert that receives fluid under pressure from a fluid inlet tube and generates a specified spatial distribution of the fluid exiting the insert includes: (1) a body member having top, bottom, front and rear outer surfaces, (2) top and bottom fluidic circuits located, respectively, at least partially within the member's top and bottom surfaces, wherein each of these circuits has at least one power nozzle, an interaction chamber, and an outlet whose exit lies within the member front surface, (3) the bottom fluidic circuit having a portion of its surface area located upstream of the power nozzle and adapted so that it can mate with a fluid inlet tube that supplies fluid to the insert, and (4) an inter-circuit flow passage that allows fluid to flow from the bottom fluid circuit to the top fluid circuit, the bottom end of this passage located such that it is downstream of the point where the inlet tube mates with the bottom circuit and upstream of the bottom circuit's power nozzle, with the top end of t

Abstract: The invention relates to vitamin-mediated targeting for the delivery of agents and active substances in the therapy of disease. Targeting using vitamins essential for cancer growth are used in complexes for amplified delivery of cytotoxic drugs to tumors and cancer cells, with a concomitant reduction in toxicity to the subject being treated.

Abstract: A backload-responsive fluidic switch having high pressure recovery of more than 50% comprises a body member with a power nozzle having a width W and a centerline CL which is adapted to be coupled to a source of fluid under pressure for issuing a jet of fluid along the centerline. A pair of diverging fluid flow passages have a common connection with the power nozzle and respective bounding walls, each respective bounding wall diverging from the centerline no more than about 50°, and a splitter defining respective inner walls of the pair of diverging walls, the splitter being spaced a distance of about 3W from the power nozzle. Inflatable bladder(s) connected to the diverging fluid flow passage(s), and a vent connected to the other of said fluid flow passages.

Abstract: A fluidic insert that receives fluid under pressure from a fluid inlet tube and generates a specified spatial distribution of the fluid exiting the insert includes: (1) a body member having top, bottom, front and rear outer surfaces, (2) top and bottom fluidic circuits located, respectively, at least partially within the member's top and bottom surfaces, wherein each of these circuits has at least one power nozzle, an interaction chamber, and an outlet whose exit lies within the member front surface, (3) the bottom fluidic circuit having a portion of its surface area located upstream of the power nozzle and adapted so that it can mate with a fluid inlet tube that supplies fluid to the insert, and (4) an inter-circuit flow passage that allows fluid to flow from the bottom fluid circuit to the top fluid circuit, the bottom end of this passage located such that it is downstream of the point where the inlet tube mates with the bottom circuit and upstream of the bottom circuit's power nozzle, with the top end of t

Abstract: A backload-responsive fluidic switch having high pressure recovery of more than 50% comprises a body member with a power nozzle having a width W and a centerline CL which is adapted to be coupled to a source of fluid under pressure for issuing a jet of fluid along the centerline. A pair of diverging fluid flow passages have a common connection with said power nozzle and respective bounding walls, each respective bounding wall diverging from the centerline no more than about 50°, and a splitter defining respective inner walls of said pair of diverging walls, the splitter being spaced a distance of about 3W from the power nozzle. Inflatable bladder(s) connected to the diverging fluid flow passage(s), and a vent connected to the other of said fluid flow passages.

Abstract: An all-terrain vehicle (ATV) can be secured to a truck or trailer bed, for transporting on roads or highways, using adjustable-length connectors with rigid shafts, rather than chains, ropes, or cables. Two steel "tine pins" (or comparable rigid structures, such as rounded eye hooks) are securely mounted on opposed ends or sides of the ATV. Similar tine pins are also mounted on the bed of a trailer or truck used to carry the ATV. The ATV is loaded onto the trailer or truck, moved into position (this does not require precise placement) and secured by turnbuckle-type securing connectors which have adjustable lengths. Unlike chains or ropes, these adjustable connectors become rigid and non-yielding after their lengths have been adjusted. An eyehole which accommodates a tine pin is provided at each end of each connector.

Abstract: A dispensing apparatus for dispensing contents from a container. The container rests upon a support in the apparatus and has an outlet at one end from which contents are directly dispersed and cover at its other end. The apparatus has a ram with a ram member engageable against the cover to move the cover between a first position adjacent the other end to a position adjacent the outlet to dispense contents from the container. The pressure exerted on the cover by the ram member is released after a dispensing operation.

Abstract: A calibration apparatus is applied to a gas control panel (46) that uses mass flow controllers (70,98,118) to control the flows of different gases to a processing chamber (42). The gas control panel (46) includes a mass flow meter (150) mounted on the gas control panel (46). The mass flow meter (150) is connected between pre-existing and unused gas valves (152, 156) on the gas control panel (46) in place of a mass flow controller that is also otherwise unused. The meter input valve (152) for the mass flow meter (150) is in fluid communication with the mass flow controllers (70, 98, 118). The input and output meter valves (152, 156) are connected to respective pre-existing solenoids (154, 158) which in turn are connected to a gas flow control (48). A final valve solenoid (82) controls a final valve (80) which is also in fluid communication with the mass flow controllers (70, 98, 118) and routes the gases to the processing chamber (42).

Abstract: Nanoparticles containing an active substance and a ketalized polytartramidic acid, process for their preparation, and use thereof. Nanoparticles containing an active substance and a ketalized polytartramidic acid are suitable as vehicles for active substances, in particular for peptides and proteins. Processes for the preparation of the nanoparticles are described.

Abstract: An improved trailer hitch which can be used to more easily attach a trailer to a towing vehicle by simply engaging a horizontal coupling shaft in a latch assembly, and closing the latch. The trailer hitch comprises six main components: a yoke assembly, a latch assembly, a transverse horizontal coupling shaft, a connector bar, a trailer yoke and a pivot bolt. The yoke assembly provides for rotation about the vertical axis, the latch assembly provides for rotation about the transverse horizontal axis, and the pivot bolt for rotation around the longitudinal horizontal axis. A trailer can be easily attached to a towing vehicle by placing the transverse horizontal shaft in the latch assembly, and closing and fastening the latch.