Abstract: An apparatus includes a sub-surface safety valve (SSSV) to be positioned in a wellbore. The SSSV is configurable to move between a closed position and an open position. While in the closed position, the SSSV prevents downhole fluid in the wellbore to flow to a surface of the wellbore. While in the open position, the SSSV allows the downhole fluid in the wellbore to flow to the surface of the wellbore. The apparatus further includes an electrostatic motor to be positioned in the wellbore and to be coupled to the SSSV. The electrostatic motor is to be selectively powered to move the SSSV between the closed position and the open position.

Abstract: The present invention provides hepcidin analogues with improved in vivo half lives, and related pharmaceutical compositions and methods of use thereof.

Abstract: Various embodiments related to three dimensional printers, and reinforced filaments, and their methods of use are described. In one embodiment, a void free reinforced filament is fed into an extrusion nozzle. The reinforced filament includes a core, which may be continuous or semi-continuous, and a matrix material surrounding the core. The reinforced filament is heated to a temperature greater than a melting temperature of the matrix material and less than a melting temperature of the core prior to extruding the filament from the extrusion nozzle.

Abstract: Methods and systems for forecasting demand for items across multiple channels are disclosed. In some implementations, multi-channel demand forecasting may be performed on a per-item, per-location basis, by selectively generating item-location forecasts for each item and location within a supply chain for each channel, or disaggregating a chain level forecast on a per-item basis to each location. Particular selection of an appropriate model, and selective training of models, allows for efficient computation of such forecasts across a large supply chain with thousands of locations and hundreds of thousands, or millions, of items for which forecasts are generated.

Abstract: The present invention provides hepcidin analogues with improved in vivo half lives, and related pharmaceutical compositions and methods of use thereof.

Abstract: In one aspect of the present disclosure, a device may include a shaft having a distal end, and a tip at the distal end of the shaft. The tip may include an opening defined by a surface of the tip. An instrument inserted through the shaft may extend distally out of the opening. The device also may include an elevator for engaging the instrument. The elevator may include a proximal end fixed relative to the surface of the tip, a proximal portion extending distally from the proximal end, and a distal portion extending distally from the proximal portion. A force exerted on the elevator bends the proximal portion to deflect the distal portion without bending of the distal portion.

Abstract: A base station antenna includes a remote electronic tilt (“RET”) actuator, a phase shifter having a moveable element and a mechanical linkage extending between the RET actuator and the phase shifter. The mechanical linkage includes an adjustable RET linkage that has a first link that has a first connection element, a second link that has a second connection element and a connecting member that includes at least a third link. The adjustable RET linkage includes at least a first hinge and a second hinge.

Abstract: A blade includes an airfoil defined by a pressure side outer wall and a suction side outer wall connecting along leading and trailing edges and form a radially extending chamber for receiving a coolant flow. A rib configuration may include: a leading edge transverse rib connecting the pressure side outer wall and the suction side outer wall and partitioning the radially extending chamber into a leading edge passage within the leading edge of the airfoil and a central passage adjacent to the leading edge passage. One or both camber line ribs connect to a corresponding pressure side outer wall and suction side outer wall at a point aft of the leading edge transverse rib causing the central passage to extend towards one or both of the pressure side outer wall and the suction side outer wall, resulting in a flared center cavity aft of the leading edge.

Abstract: Provided are ulinastatin glycoforms, ulinastatin fusion polypeptides, and related compositions, mixtures, and methods of use, including methods of recombinantly producing ulinastatin polypeptides and treating diseases.

Abstract: A multifunctional assembly having a resistive element a conductive element in electrical communication with the resistive element, the conductive element defining at least one of a plurality of multifunctional zones of the resistive element, wherein the conductive element is configured to direct a flow of electricity across at least one of the plurality of multifunctional zones of the resistive element in a preselected manner.

Abstract: Systems, apparatus and methods of additively manufacturing objects are disclosed. Specifically, provided herein are methods of heating objects having a particle-based support at least partially surrounding the object during portions of stages of the heating. Additionally, systems, apparatus, and methods for removing the particle-based support during heating, such that the object can continue heating to form a final part. Systems, apparatus, and methods for distributing the particle-based support to shore the objects through heating are disclosed. Systems, apparatus, and methods for removing the particle-based support are also disclosed herein.

Abstract: A novel and improved elbow prosthesis and method of implanting same including a prosthesis system that has a retaining system. The joint prosthesis system can include an implant, and an alignment guide. The alignment guide can include a post member extending through a central axis of rotation in a prosthesis and a drill guide member having a first limiting member for limiting articular surface removal from a joint. The first limiting member can include a recessed guide for positioning the implant.

Abstract: A secure, remote support platform allows secure, remote device support with an edge device (101) and a trusted intermediary server resource (“trusted server”). The trusted server (113) is an endpoint for secure connections with a support application used by a remote technician and with the edge device. The secure connections carry messages with inputs, data requests, and feedback. Messages between the trusted server and support edge device are secured in a manner that allows each endpoint to validate the messages. The remote technician controls the edge device to assesses a target device connected to the edge device. The edge device presents emulated peripheral devices to the target device while capturing the target device desktop with a camera or presents remotely controlled peripherals and returns screen captures or updates of the desktop from the target device.

Abstract: A remote technical support system includes an edge device that operates as a highly secured conduit for a technician to view, access, and control a target device via a secure protocol over a connection medium between the edge device and the target device. The edge device's architecture allows it to selectively present numerous peripheral devices to the target device. The architectural components of the edge device can be controlled by a technician through a secure connection with a trusted server which allows authorized to access the edge device. The edge device also relays technician commands to and obtains diagnostic information from the target device and communicates feedback to the technician over the secure connection. The commands may be relayed to the target via the one or more selectively connected USB peripherals.

Abstract: A piston oil squirter is selectively opened when an oil temperature is below a threshold oil temperature to transfer heat from the combustion chamber and heat the oil more rapidly when the engine is cold.

Abstract: The present invention provides novel peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel diseases.

Abstract: Systems and methods for wireless telemetry in oil and gas wells use fluid pressure differentials to send signals from surface equipment to a downhole tool. More specifically, the methods and systems selectively apply fluid pressure to a tubing string and measure the resulting mechanical strain, or deformation, on a tubular of the downhole tool. The deformation may be an elastic deformation or it may be a plastic deformation with yielding of the tubular. One or more of such strains or deformations may be used to encode a digital signal that can command an action on the tool. The strain or deformation may be measured by a low-cost strain gauge.