Patents by Inventor Gregory Acland

Gregory Acland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20070161033
    Abstract: Provided is a method for identifying dogs as likely to be genetically normal, carriers of, or affected with progressive rod-cone degeneration comprising analyzing nucleic acids from a dog and determining the presence or absence of one or more prcd polymorphisms in the nucleic acids. Representative prcd polymorphisms characteristic of a prcd haplotype are also provided.
    Type: Application
    Filed: December 13, 2006
    Publication date: July 12, 2007
    Inventors: Gregory Acland, Gustavo Aguirre, Orly Goldstein, Barbara Zangerl, Susan Pearce-Kelling, Duska Sidjanin, Jeanette Felix
  • Publication number: 20070077228
    Abstract: A method for treating an ocular disorder characterized by the defect or absence of a normal gene in the ocular cells of a human or animal subject involves administering to the subject by subretinal injection an effective amount of a recombinant adeno-associated virus carrying a nucleic acid sequence encoding the normal gene under the control of a promoter sequence which expresses the product of the gene in the ocular cells. The ocular cells are preferably retinal pigment epithelial (RPE) cells, and the gene is preferably an RPE-specific gene, e.g., RPE65. The promoter is one that can express the gene product in the RPE cells. Compositions for subretinal administration are useful in this method.
    Type: Application
    Filed: August 28, 2006
    Publication date: April 5, 2007
    Applicants: The Trustees of the University of Pennsylvania, The University of Florida Research Foundation, Inc, Cornell Research Foundation, Inc.
    Inventors: Gregory Acland, Gustavo Aguirre, Jean Bennett, William Hauswirth, Samuel Jacobson, Albert Maguire
  • Publication number: 20060115843
    Abstract: The invention relates to a method for identifying dogs which are genetically normal, heterozygous for, or homozygous for the mutation primarily responsible for Collie eye anomaly (CEA). The method comprises the steps of obtaining a biological sample from a dog and testing DNA in the biological sample for the presence or absence of a 7.8 kilobase deletion within chromosome 37 in which the CEA mutation is located. No deletion is indicative of a normal dog. A deletion on one allele of chromosome 37 is indicative of a dog that is heterozygous for the CEA mutation. A deletion in both alleles of chromosome 37 are indicative of a dog that is homozygous for the CEA mutation. Also provided is a kit for identifying a dog as normal, heterozygous for, or homozygous for the CEA mutation.
    Type: Application
    Filed: October 20, 2005
    Publication date: June 1, 2006
    Inventors: Gregory Acland, Anna Kukekova, Gustavo Aguirre, Elaine Ostrander, Dayna Akey, Orly Goldstein
  • Publication number: 20050282212
    Abstract: Tools and methods are provided for determining whether or not a dog is genetically normal, is a carrier of, or is affected with or predisposed to progressive rod-cone degeneration. The method is based on the detection of a transversion from G to A at position corresponding to nucleotide position 1298 of SEQ ID NO: 1.
    Type: Application
    Filed: June 21, 2005
    Publication date: December 22, 2005
    Inventors: Gustavo Aguirre, Gregory Acland, Barbara Zangerl, Orly Goldstein, Susan Pearce-Kelling, Jeanette Felix, Duska Sidjanin
  • Patent number: 5804388
    Abstract: Provided are nucleic acid molecules which comprise at least a portion of a polymorphic genetic marker for determining whether a canine has a mutated progressive rod-cone degeneration disease (prcd) gene locus in one or both alleles. The genetic markers are located on canine chromosome 9 in a genomic region identified as the prcd-informative region. A method for making genetic markers representing polymorphic sequences located in the prcd-informative region of canine chromosome 9 comprises isolating a polymorphic DNA sequence in the prcd-informative region, using oligonucleotides complementary with at least a portion of the sequence to amplify the sequence, and analyzing canine chromosome 9 in a prcd-informative pedigree for the ability of the polymorphic sequence to co-segregate with the prcd gene locus by a linkage test.
    Type: Grant
    Filed: July 10, 1997
    Date of Patent: September 8, 1998
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Gustavo Aguirre, Gregory Acland, Kunal Ray