Patents by Inventor Gregory Allan SACHA

Gregory Allan SACHA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIBODY-DRUG CONJUGATE LYOPHILISED FORMULATION
    Publication number: 20240091373
    Abstract: Disclosed herein are surfactant free lyophilized formulations of antibody-drug conjugates (ADCs), such as anti-tissue factor ADCs, and reconstituted formulations, processes and uses thereof. The formulations are particularly suitable for an anti-TF ADC based on an auristatin derivative or other similarly hydrophobic drug. Typically, the excipients of the formulations comprise or consist of histidine, sucrose, trehalose, mannitol and glycine.
    Type: Application
    Filed: December 13, 2022
    Publication date: March 21, 2024
    Inventors: Jesper VALBJØRN, Xiaona JING, Kelly Ann ROBY, Timothy Warren PAUL, Gregory Allan SACHA, Nathan Alan PEASE, Bodil WILLUMSEN
  • ANTIBODY-DRUG CONJUGATE LYOPHILISED FORMULATION
    Publication number: 20200246477
    Abstract: Disclosed herein are surfactant free lyophilized formulations of antibody-drug conjugates (ADCs), such as anti-tissue factor ADCs, and reconstituted formulations, processes and uses thereof. The formulations are particularly suitable for an anti-TF ADC based on an auristatin derivative or other similarly hydrophobic drug. Typically, the excipients of the formulations comprise or consist of histidine, sucrose, trehalose, mannitol and glycine.
    Type: Application
    Filed: January 14, 2020
    Publication date: August 6, 2020
    Inventors: Jesper VALBJØRN, Xiaona JING, Kelly Ann ROBY, Timothy Warren PAUL, Gregory Allan SACHA, Nathan Alan PEASE, Bodil WILLUMSEN
  • Lyophilized anti-tissue factor antibody-drug conjugates
    Patent number: 10617764
    Abstract: Disclosed herein are surfactant free lyophilized formulations of antibody-drug conjugates (ADCs), such as anti-tissue factor ADCs, and reconstituted formulations, processes and uses thereof. The formulations are particularly suitable for an anti-TF ADC based on an auristatin derivative or other similarly hydrophobic drug. Typically, the excipients of the formulations comprise or consist of histidine, sucrose, trehalose, mannitol and glycine.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: April 14, 2020
    Assignee: GENMAB A/S
    Inventors: Jesper Valbjørn, Xiaona Jing, Kelly Ann Roby, Timothy Warren Paul, Gregory Allan Sacha, Nathan Alan Pease, Bodil Willumsen
  • FORMULATION FOR ANTIBODY AND DRUG CONJUGATE THEREOF
    Publication number: 20190030180
    Abstract: Disclosed herein are surfactant free antibody and antibody-drug-conjugate (ADC) formulations for anti-AXL antibodies and ADCs, including aqueous formulations, lyophilized formulations, and reconstituted formulations, as well as related processes and uses. The formulations are particularly suitable for an anti-AXL ADC based on an auristatin or DM1 derivative or other similarly hydrophobic drugs. Some formulations comprise histidine and mannitol.
    Type: Application
    Filed: January 13, 2017
    Publication date: January 31, 2019
    Inventors: Lene Schantz HARLOW, Timothy Warren PAUL, Brendan M. MAYHUGH, Kelly Ann ROBY, Gregory Allan SACHA, Xiaona JING, Andrew HAGARMAN, Cale HALBLEIB
  • ANTIBODY-DRUG CONJUGATE LYOPHILISED FORMULATION
    Publication number: 20160279258
    Abstract: Disclosed herein are surfactant free lyophilized formulations of antibody-drug conjugates (ADCs), such as anti-tissue factor ADCs, and reconstituted formulations, processes and uses thereof. The formulations are particularly suitable for an anti-TF ADC based on an auristatin derivative or other similarly hydrophobic drug. Typically, the excipients of the formulations comprise or consist of histidine, sucrose, trehalose, mannitol and glycine.
    Type: Application
    Filed: November 21, 2014
    Publication date: September 29, 2016
    Inventors: Jesper VALBJØRN, Xiaona JING, Kelly Ann ROBY, Timothy Warren PAUL, Gregory Allan SACHA, Nathan Alan PEASE, Bodil WILLUMSEN