Abstract: Provided herein, among other things, is a cytotoxic immune cell (e.g., a cytotoxic T cell) that expresses an engineered immune receptor (such as a CAR or TCR) whose cytotoxicity within the tumor microenvironment is enhanced by a pro-inflammatory protein that is induced only when the cell binds to either a tissue-specific or cancer-associated antigen. As such, the present cells can be used for the treatment of cancers that are associated with solid tumors.

Abstract: Provided herein is a cytotoxic immune cell that is primed by and/or whose cytotoxicity within the tumor microenvironment is enhanced by binding to a stromal marker, e.g., Fibroblast Activation Protein Alpha (FAP). In some embodiments, the cells may contain a protein circuit that contains at least two components, wherein one of the components binding-triggered transcriptional switch that is activated by binding to the stromal marker. The second component may be a nucleic acid encoding an immune receptor (e.g., a chimeric antigen receptor or TCR) that is activated by binding to a cancer-specific antigen and/or a pro-inflammatory cytokine.

Abstract: This disclosure discloses a network-based computing technology to evaluate relationships between social networking profiles and then to take an action based on such evaluation. This network-based computing technology may include a running logic, whether hardware or software, such as an engine, which may be modularized, that is programmed to score the relationships based on shared content.

Abstract: The present disclosure provides immune cells genetically modified to produce two antigen-triggered polypeptides, each recognizing a different cell surface antigen, wherein the two different cell surface antigens employed are selected from those pairs described herein. The present disclosure further provides systems comprising two antigen-triggered polypeptides (or nucleic acids encoding same), each recognizing a different cell surface antigen, wherein the two different cell surface antigens employed are selected from those pairs described herein. Also provided are method of killing a target cancer cell, using the described genetically modified immune cells and/or systems. The present disclosure also provides polyspecific-immune inducing polypeptides including first and second antigen binding domains specific for first and second antigens, respectively, present on the surface of a target cancer cell.

Abstract: This disclosure discloses a network-based computing technology to evaluate relationships between social networking profiles and then to take an action based on such evaluation. This network-based computing technology may include a running logic, whether hardware or software, such as an engine, which may be modularized, that is programmed to score the relationships based on shared content.

Abstract: This disclosure discloses a network-based computing technology to evaluate relationships between social networking profiles and then to take an action based on such evaluation. This network-based computing technology may include a running logic, whether hardware or software, such as an engine, which may be modularized, that is programmed to score the relationships based on shared content.

Abstract: This disclosure discloses a network-based computing technology to evaluate relationships between social networking profiles and then to take an action based on such evaluation. This network-based computing technology may include a running logic, whether hardware or software, such as an engine, which may be modularized, that is programmed to score the relationships based on shared content.

Abstract: This disclosure discloses a network-based computing technology to evaluate relationships between social networking profiles and then to take an action based on such evaluation. This network-based computing technology may include a running logic, whether hardware or software, such as an engine, which may be modularized, that is programmed to score the relationships based on shared content.

Abstract: This disclosure discloses a network-based computing technology to evaluate relationships between social networking profiles and then to take an action based on such evaluation. This network-based computing technology may include a running logic, whether hardware or software, such as an engine, which may be modularized, that is programmed to score the relationships based on shared content.

Abstract: A fenestration assembly comprising a sliding glass assembly that slides between a fully closed position and a fully open position in which the sliding glass assembly is received into a pocket of the fenestration assembly. The pocket is covered on at least one side with insulation. The fenestration assembly may have two sliding glass assemblies. The fenestration assembly may be used in an energy efficient building system.

Abstract: A fenestration assembly comprising a sliding glass assembly that slides between a fully closed position and a fully open position in which the sliding glass assembly is received into a pocket of the fenestration assembly. The pocket is covered on at least one side with insulation. The fenestration assembly may have two sliding glass assemblies. The fenestration assembly may be used in an energy efficient building system.

Abstract: A method of predictive analysis, including the steps of (a) selecting a sequence of discrete information signals for a time interval; (b) identifying one or more creators of the a group the discrete information signals, the one or more creators comprising a first group of social media participants; (c) selecting a group of observers of the sequence of discrete information signals, the observers comprising a second group of social media participants; (d) selecting a sub-group of observers from the group of the observers, the sub-group comprising one or more individuals of the group of observers who have taken external actions subsequent to the time interval; and (e) determining the existence or absence of one or more dependencies between the among the first group and the second group of media participants.

Abstract: A method of predictive analysis, including the steps of (a) selecting a sequence of discrete information signals for a time interval; (b) identifying one or more creators of the a group the discrete information signals, the one or more creators comprising a first group of social media participants; (c) selecting a group of observers of the sequence of discrete information signals, the observers comprising a second group of social media participants; (d) selecting a sub-group of observers from the group of the observers, the sub-group comprising one or more individuals of the group of observers who have taken external actions subsequent to the time interval; and (e) determining the existence or absence of one or more dependencies between the among the first group and the second group of media participants.

Abstract: A fenestration assembly comprising a sliding glass assembly that slides between a fully closed position and a fully open position in which the sliding glass assembly is received into a pocket of the fenestration assembly. The pocket is covered on at least one side with insulation. The fenestration assembly may have two sliding glass assemblies. The fenestration assembly may be used in an energy efficient building system.

Abstract: A wellhead assembly to seal and suspend an in-casing hydraulic drive unit for a downhole pump, including pressure-containing wellhead body members with a vertical bore and a production bore at its uppermost portion. A hydraulic pump hanger is retained and sealed in the vertical bore. The hydraulic pump hanger suspends and seals the hydraulic cylinder, includes a bore extending vertically therethrough, forms at least one hydraulic line to communicate with hydraulic fluid supply lines, forms a hydraulic inlet port to each hydraulic line, and provides a check valve sealed in each hydraulic inlet port. The wellhead body member(s) includes a stem port aligned with each hydraulic inlet port, with a valve actuating stem sealed in each stem port to actuate each check valve between a normally closed and open position. The wellhead body member(s) also includes hydraulic injection port(s) formed to supply hydraulic fluid to each hydraulic inlet port.

Abstract: The present invention provides a novel system and method for failover. In an embodiment, a primary server and a backup server are available to a plurality of clients. Messages containing requests are processed by the primary server, while a mirror image of transaction records generated by the processing of those requests is maintained in volatile memory of both the primary server and the backup server. In this mode of operation, the volatile memory is periodically flushed to non-volatile memory.

Abstract: A process for continually compensating for the microjog error resulting from RRO. Typically, the 1F RRO is the most significant, but the method could be applied to the microjog error caused by RRO of other frequencies. The process continually determines an instantaneous microjog error based on the RRO and adjusts the read element target position throughout one revolution, such that the write element remains centered on its intended position.

Abstract: A device that insures peace of mind from steering wheel airbags deploying on First Responders after being installed. A device that weighs less than two pounds. My device is made of the strongest fabrics known and has a lock down strap built in that requires only one person to install in seconds. All you do is slip the device over the steering wheel and cinch down strap securing it to the steering wheel.

Abstract: The present invention provides a novel system and method for executing orders. In an embodiment, a system for executing orders includes a communications gateway through which orders and intents can be passed to an internalization engine. The internalization is operable to maintain intents and compare them with incoming orders, and with market feeds of best bid offers, in order to match up certain incoming orders with intents from the same firm in accordance with market rules. Where no match is made, the order is passed to a trading engine, also connected to the communications gateway, so that the order can be processed in the usual manner. Where a match is made, an appropriate portion of the intent is paired with the order and a trade notification is sent to the trading engine for processing in the usual manner.