Abstract: A MEMS/NEMS device having an adjustable frequency response comprises an array of electrostatically actuated resonators, an electrostatic actuation circuit, electrical detection means, and means adjusting the frequency response of the resonators. The device comprises resonators having a movable portion, electrically connected in series between a first biasing potential VB and a second biasing potential VB2, each resonator biased to a potential Vi between VB and VB2, depending on position in the series. The electrostatic actuation circuit comprises, for each resonator, an actuation electrode facing the movable portion, all electrodes being connected in parallel to a common control potential VIN, the actuation voltage of each resonator being equal to VIN?Vi. The detection means comprises a detection output common to all resonators, the output being connected to an output potential Vout.

Abstract: A delta sigma analog-to-digital converter (ADC) providing optimized performance and energy consumption. In one embodiment, a delta-sigma ADC includes a loop filter and a multi-bit quantizer. The multi-bit quantizer is coupled to the loop filter. The quantizer includes a counter, a reference voltage generator, and a comparator. The counter is configured to provide a multi-bit output value that estimates an output of the loop filter. The reference voltage generator is configured to generate a reference voltage ramp based on the output value of the counter. The comparator is coupled to the reference voltage generator to compare the reference voltage ramp to output of the loop filter.

Abstract: A delta sigma analog-to-digital converter (ADC) providing optimized performance and energy consumption. In one embodiment, a delta-sigma ADC includes a loop filter and a multi-bit quantizer. The multi-bit quantizer is coupled to the loop filter. The quantizer includes a counter, a reference voltage generator, and a comparator. The counter is configured to provide a multi-bit output value that estimates an output of the loop filter. The reference voltage generator is configured to generate a reference voltage ramp based on the output value of the counter. The comparator is coupled to the reference voltage generator to compare the reference voltage ramp to output of the loop filter.

Abstract: A MEMS/NEMS device having an adjustable frequency response comprises an array of electrostatically actuated resonators, an electrostatic actuation circuit, electrical detection means, and means adjusting the frequency response of the resonators. The device comprises resonators having a movable portion, electrically connected in series between a first biasing potential VB and a second biasing potential VB2, each resonator biased to a potential Vi between VB and VB2, depending on position in the series. The electrostatic actuation circuit comprises, for each resonator, an actuation electrode facing the movable portion, all electrodes being connected in parallel to a common control potential VIN, the actuation voltage of each resonator being equal to VIN?Vi. The detection means comprises a detection output common to all resonators, the output being connected to an output potential Vout.

Abstract: Methods of treating disorders related to Oxytocin Receptor activity utilize OXYTOCIN RECEPTOR antagonists, such as antibodies, including specified portions or variants, polypeptides, polynucleotides, small molecule drugs, siRNA, shRNA, and DNAzymes. Disorders related to Oxytocin Receptor activity include inflammatory disorders, such as pulmonary disorders, for example, asthma, emphysema, and COPD.

Abstract: Interfering RNA molecules are now designed and produced with specificity for multiple binding sequences present in distinct genetic contexts in one or more pre-selected target RNA molecules and are used to modulate expression of the target sequences. The multitargeting interfering RNA molecules have two strands that target multiple target sites on one or more pre-selected RNA molecules. Such a multitargeting interfering RNA approach provides a powerful tool for gene regulation.

Abstract: CNGH0011 polypeptides and nucleic acids encoding a variety of proteins have diagnostic, preventive, therapeutic, and other uses for a number of human and other animal disorders. Nucleic acid antagonist molecules (siRNA, shRNA, among others), expression vectors containing nucleic acid molecules, host cells into which the expression vectors have been introduced, fusion polypeptides, antigenic peptides and antibodies can be utilized to control the level of protein and regulate a variety of cellular processes in diagnostic, screening, and therapeutic methods.