Abstract: A microscope slide holding cassette includes a main body for surrounding and protecting microscopes, and shelves capable of holding the microscope slides. The shelves have support members that extend outwardly in order to support label ends of slides. Catches carried at the end of the support members are capable of limiting movement of the slides during transport of the cassette. To transport slides to different workstations, a pickup device can use a vacuum to pick up a slide without contacting areas of the slide that may have glue. The pickup device can load and unload the cassette. The pickup device can have a low-profile configuration in order to access relatively small spaces for processing flexibility.

Abstract: Disclosed herein, in certain embodiments, is a method of manipulating a microscopy slide image. Disclosed herein, in certain embodiments, is a method of panning across the entire width and height of a microscopy slide image. Disclosed herein, in certain embodiments, is a method of changing the magnification of a microscopy slide image.

Abstract: An integrated monitoring and body fluid sampling device constructed to permit digital as well as alternate-site body fluid sampling and analysis, the device comprising: a housing; at least one skin-penetration member; and a member constructed for the application of circumferential or vacuum pressure to an appendage; wherein the member is detachably or retractably connected to the housing in a manner such that the integrated monitoring and body fluid sampling device can perform digital or alternate-site body fluid sampling and analysis. Additional arrangements and techniques are also described.

Abstract: Disclosed herein, in certain embodiments, is a method of manipulating a microscopy slide image. Disclosed herein, in certain embodiments, is a method of panning across the entire width and height of a microscopy slide image. Disclosed herein, in certain embodiments, is a method of changing the magnification of a microscopy slide image.

Abstract: Disclosed herein, in certain embodiments, is a method of treating breast cancer characterized by the amplification of HER2 genes in a subject in need thereof, comprising: (a) isolating a tissue sample comprised of a plurality of breast tumor cells; (b) isolating a first section from said tissue sample; (c) isolating a second section from an adjacent portion of said tissue sample; (d) contacting the first section with a first stain; (e) contacting the second section with a probe; (f) imaging the first section following contact with the stain to produce a first image; (g) analyzing the first image for abnormal microscopic features; (h) identifying areas of interest in the first image that display abnormal microscopic features; (i) electronically annotating the first image to identify the areas of interest; (j) imaging the second section following contact with the probe; (k) aligning the first image and the second image; and (l) analyzing areas of interest in the second image that correspond to an area of intere

Abstract: An integrated monitoring and body fluid sampling device constructed to permit digital as well as alternate-site body fluid sampling and analysis, the device comprising: a housing; at least one skin-penetration member; and a member constructed for the application of circumferential or vacuum pressure to an appendage; wherein the member is detachably or retractably connected to the housing in a manner such that the integrated monitoring and body fluid sampling device can perform digital or alternate-site body fluid sampling and analysis. Additional arrangements and techniques are also described.

Abstract: A method for scanning a probe array is described. The method comprises tuning an excitation light to a plurality of wavelengths each within an excitation range of a fluorescent label associated with one or more target molecules; and directing the tuned excitation light of each wavelength at the probe array.

Abstract: A system is described for providing focus elements associated with a biological probe array that comprises a biological probe array enabled to hybridize target molecules to probes disposed in an active area of the biological probe array; and focus elements disposed on the biological probe array, where the focus elements represent an unambiguous pattern.

Abstract: A system is described for providing a wavelength of light that comprises: a scanner that provides a first wavelength; and an optical assembly that emits a second wavelength based, at least in part upon the first wavelength, wherein the second wavelength is not the result of a fluorescent emission.

Abstract: A steering mirror assembly operates in a stable manner with a high bandwidth, with one to two degree peak-to-peak angular stroke. The steering mirror assembly includes a mirror for directing signals to their destination by reflection. The steering mirror may be moved through any position in a cone of several degrees. Movement of the mirror is achieved by a number of actuators. The mirror is coupled to a flexure ring that locks out undesirable directions of motion. The mirror assembly also includes position sensor that indicate to the assembly where the mirror is currently positioned. Data from these sensors is used as feedback to appropriately adjust mirror position.