Abstract: Certain embodiments are directed to methods of treating or preventing an addictive behavior in a subject by administering to the subject an effective amount of a 5-HT2C receptor agonist in combination with a DA D3/D4 receptor antagonist.

Abstract: A method and apparatus are provided for a hemodiafiltration delivery module that is used in conjunction with a UF controlled dialysis machine to enable hemodiafiltration therapy to be performed. The advantage is that one can fully utilize a current functioning dialysis machine to perform a hemodiafiltration therapy as opposed to purchasing a completely new machine that offers this capability.

Abstract: Certain embodiments are directed to methods of treating or preventing an addictive behavior in a subject by administering to the subject an effective amount of a 5-HT2C receptor agonist in combination with a DA D3/D4 receptor antagonist.

Abstract: A flushable filter system is configured to purify a contaminated liquid containing substances that degrade filter performance and includes a filter cartridge including semi-permeable hollow fiber membrane that separates the filter cartridge into an upstream compartment and a downstream compartment. The system includes a flush port in communication with the upstream compartment of the filter cartridge for periodically discharging accumulated particulates and contaminates from an upstream side of the semi-permeable hollow fiber membrane. A device is provided to reduce mechanical stress imposed on the semi-permeable hollow fiber membrane during operation of the flushable filter system resulting in maintenance of integrity of the semi-permeable hollow fiber membrane during extended use and cyclic operation of the filter cartridge. The device is configured to dampen any fluid pressure spike that is observed within the flushable filter system during operation thereof.

Abstract: A flush pump feature on a liquid purifying filter includes a segment of flexible tubing containing a small bulb pump is described. Two check valves are positioned upstream and downstream of the bulb pump which then terminates with a simple manually operated open/closed valve. The addition of this flush pump feature enables the filter unit to be easily purged of air at first use and also will make the filter easier to clean and maintain without the need to remove it from a hydration carrier. In addition, the flush bulb feature can also be used to perform a simple visual integrity test of filter while out in a remote location and also can be used to effectively remove bulk water from the filter for lighter storage when not in use which also minimizes freeze related damage when used in a cold environment.

Abstract: A flush pump feature on a liquid purifying filter includes a segment of flexible tubing containing a small bulb pump is described. Two check valves are positioned upstream and downstream of the bulb pump which then terminates with a simple manually operated open/closed valve. The addition of this flush pump feature enables the filter unit to be easily purged of air at first use and also will make the filter easier to clean and maintain without the need to remove it from a hydration carrier. In addition, the flush bulb feature can also be used to perform a simple visual integrity test of filter while out in a remote location and also can be used to effectively remove bulk water from the filter for lighter storage when not in use which also minimizes freeze related damage when used in a cold environment.

Abstract: A flush pump feature on a liquid purifying filter includes a segment of flexible tubing containing a small bulb pump is described. Two check valves are positioned upstream and downstream of the bulb pump which then terminates with a simple manually operated open/closed valve. The addition of this flush pump feature enables the filter unit to be easily purged of air at first use and also will make the filter easier to clean and maintain without the need to remove it from a hydration carrier. In addition, the flush bulb feature can also be used to perform a simple visual integrity test of filter while out in a remote location and also can be used to effectively remove bulk water from the filter for lighter storage when not in use which also minimizes freeze related damage when used in a cold environment.

Abstract: Potent and selective ligands for the dopamine 3 (D3) receptor are disclosed. The D3 receptor ligands have a structural formula: wherein R1 is C1-6 alkyl or C3-6cycloalkyl; or wherein R2 is substituted with one or two halogen(s) or OC1-3alkyl.

Abstract: The present invention relates to trans-capsularly administering into a diseased joint a high specificity antagonist selected from the group consisting of: i) an inhibitor of a pro-inflammatory interleukin; ii) an inhibitor of TNF-? synthesis; iii) an inhibitor of membrane-bound TNF-?; iv) an inhibitor of a natural receptor of TNF-?; v) an inhibitor of NO synthase, vi) an inhibitor of PLA2 enzyme; vii) an anti-proliferative agent; viii) an anti-oxidant; ix) an apoptosis inhibitor selected from the group consisting of EPO mimetic peptides, EPO mimetibodies, IGF-I, IGF-II, and caspase inhibitors, and x) an inhibitor of MMPs; and xi) an inhibitor of p38 kinase.

Abstract: Potent and selective ligands for the dopamine 3 (D3) receptor are disclosed. The D3 receptor ligands have a structural formula (I) wherein X is C?O or SO2, R1 is C1-6 alkyl, R2 is aryl, heteroaryl, aryl, —(CH2)1-3aryl, or —(CH2)1-3heteroaryl, and n is 0 or 1. Methods of using the D3 receptor ligands in the treatment of diseases and conditions wherein modulation of the D3 receptor provides a benefit also are disclosed.

Abstract: Potent and selective ligands for the dopamine 3 (D3) receptor are disclosed. The D3 receptor ligands have a structural formula: wherein R1 is C1-6 alkyl or C3-6cycloalkyl; or wherein R2 is substituted with one or two halogen(s) or OC1-3alkyl.

Abstract: The present invention relates to administering a doxycycline compound into a diseased intervertebral disc.

Abstract: Potent and selective ligands for the dopamine 3 (D3) receptor are disclosed. The D3 receptor ligands have a structural formula (I) wherein X is C?O or SO2, R1 is C1-6 alkyl, R2 is aryl, heteroaryl, aryl, —(CH2)1-3aryl, or —(CH2)1-3heteroaryl, and n is 0 or 1. Methods of using the D3 receptor ligands in the treatment of diseases and conditions wherein modulation of the D3 receptor provides a benefit also are disclosed.

Abstract: A collapsible bag for carrying articles that includes a folding seat mounted on an exterior surface of the bag. The bag includes side frame members and a bottom plate that are individually pivotable relative to a base frame assembly to change the volume of the interior compartment of the bag. The bag is provided with various article retainers on its exterior surface to provide easy access to articles retained therein.

Abstract: In accordance with one embodiment, a connector for use in a fluid circuit includes a first housing having a hollow interior and an inlet and an outlet. The hollow interior includes first filter elements that are open at first and second ends thereof. The first ends of the first filter elements are in fluid communication with the inlet, while the second ends are in fluid communication with the outlet. The connector also includes a second housing that is in fluid communication with the hollow interior of the first housing. The second housing contains second filter elements that are arranged in a U-shape and are open at first and second ends thereof that are disposed proximate an outlet of the second housing. Fluid is conducted across the first filter elements to gain access to the second housing where the fluid is conducted across the second filter elements in order to exit to the second housing through the outlet.

Abstract: In one embodiment, a liquid purification system for purifying a liquid and delivering purified liquid to external downstream equipment includes a source of liquid to be purified and a filter device that is operatively coupled to and selectively in communication with the source of liquid. The filter device includes a filter element. The system also includes a controller and a means for performing a filter integrity test on the filter element, whereby the controller is configured to detect when purified liquid is being used by the downstream equipment and coordinate the initiation of the filter integrity test at time when conducting the filter integrity test does not adversely effect the operation of the downstream equipment.

Abstract: A communication system that facilitates the transmission of audio messages via dispatch communications to subscriber units as members of a distribution list. The system includes a network device (e.g., a message application server) adapted to receive a dispatch communication including an audio message from an originating subscriber unit intended for member(s) of a distribution list; post the audio message for retrieval by the members of the distribution list; send respective notifications of the posting of the audio message to the members of the distribution list; receive requests for the audio message from the members of the distribution list; and send respective dispatch communications including the audio message to the requesting members of the distribution list.

Abstract: The present invention provides a computer implemented lab reservation system including a reservation engine and a reservation database. The reservation database contains data concerning the computer systems and target operating environments in the lab. The reservation engine manipulates the reservation database in order to efficiently match user requests to specific lab computer systems and target operating environments. The reservation system also manipulates the reservation database in order to efficiently configure computer systems and target operating environments. The reservation engine also manipulates the reservation database in order to efficiently reinstall computer system default settings, when users return configured systems, so that the computer systems can be reallocated to new requests.

Abstract: The present invention relates to administering a doxycycline compound into a diseased intervertebral disc.