Patents by Inventor Gregory Cope

Gregory Cope has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Engineered imine reductases and methods for the reductive animation of ketone and amine compounds
    Patent number: 9193957
    Abstract: The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
    Type: Grant
    Filed: May 9, 2013
    Date of Patent: November 24, 2015
    Assignee: Codexis, Inc.
    Inventors: Haibin Chen, Steven J. Collier, Jovana Nazor, Joly Sukumaran, Derek Smith, Jeffrey C. Moore, Gregory Hughes, Jacob Janey, Gjalt Huisman, Scott Novick, Nicholas Agard, Oscar Alvizo, Gregory Cope, Wan Lin Yeo, Stefanie Ng Minor
  • Engineered imine reductases and methods for the reductive animation of ketone and amine compounds.
    Publication number: 20130302859
    Abstract: The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
    Type: Application
    Filed: May 9, 2013
    Publication date: November 14, 2013
    Applicant: CODEXIS,INC.
    Inventors: CHEN Haibin, Steven J. Collier, Jovana NAZOR, Joly SUKUMARAN, Derek SMITH, Jeffrey C. MOORE, Gregory HUGHES, Jacob JANEY, Gjalt HUISMAN, Scott NOVICK, Nicholas AGARD, Oscar ALVIZO, Gregory COPE, Wan Lin YEO, Stephanie NG
  • Regulation of target protein activity through modifier proteins
    Patent number: 7291494
    Abstract: The present invention is based on the discovery that a polypeptide containing the JAB subunit or the JAM domain has peptidase activity, e.g., isopeptidase activity. The present invention provides polypeptides and crystalline polypeptides containing the JAM domain and methods of using such polypeptides to screen for agents capable of affecting the peptidase activity of the polypeptides. The present invention also provides methods of using the JAM domain for rational drug design or identifying agents capable of affecting the peptidase activity of the JAM domain.
    Type: Grant
    Filed: January 14, 2002
    Date of Patent: November 6, 2007
    Assignees: California Institute of Technology, National Institutes of Health
    Inventors: Gregory Cope, Rati Verma, Lakshminarayanan Aravind, Eugene V. Koonin, Raymond Deshaies, Xavier Ambroggio
  • Modulation of COP9 signalsome isopeptidase activity
    Patent number: 7279317
    Abstract: Methods for identifying agents that can increase or decrease the isopeptidase activity of a COP9 signalsome (CSN) are provided, as are agent identified using such screening assays. In addition, methods of ameliorating a pathologic condition such as a cancer or an autoimmune disease in a subject by modulating the CSN isopeptidase activity are provided, as are medicaments useful for treating a subject having such a condition.
    Type: Grant
    Filed: January 9, 2003
    Date of Patent: October 9, 2007
    Assignee: California Institute of Technology
    Inventors: Raymond J. Deshaies, Gregory Cope, Rati Verma, Xavier I. Ambroggio
  • Regulation of target protein activity through modifier proteins
    Publication number: 20030166243
    Abstract: The present invention is based on the discovery that a polypeptide containing the JAB subunit or the JAM domain has peptidase activity, e.g. isopeptidase activity. The present invention provides polypeptides and crystalline polypeptides containing the JAM domain and methods of using such polypeptides to screen for agents capable of affecting the peptidase activity of the polypeptides. The present invention also provides methods of using the JAM domain for rational drug design or identifying agents capable of affecting the peptidase activity of the JAM domain.
    Type: Application
    Filed: January 14, 2002
    Publication date: September 4, 2003
    Inventors: Gregory Cope, Rati Verma, L. Aravind, Eugene V. Koonin, Raymond Deshaies, Xavier Ambroggio
  • Modulation of COP9 signalsome isopeptidase activity
    Publication number: 20030153097
    Abstract: Methods for identifying agents that can increase or decrease the isopeptidase activity of a COP9 signalsome (CSN) are provided, as are agent identified using such screening assays. In addition, methods of ameliorating a pathologic condition such as a cancer or an autoimmune disease in a subject by modulating the CSN isopeptidase activity are provided, as are medicaments useful for treating a subject having such a condition.
    Type: Application
    Filed: January 9, 2003
    Publication date: August 14, 2003
    Inventors: Raymond J. Deshaies, Gregory Cope, Rati Verma, Xavier I. Ambroggio