Abstract: The present application describes stapled peptide degron chimeras, which act as protein degradation inducing moieties, either by combining a stapled peptide that binds a disease-related protein with a small molecule degron, such as a cereblon- or VHL-binding small molecule as the degron, or a polypeptide sequence degron, such as a Cop1-binding Trib peptide as the degron; or by combining a stapled peptide degron with a peptide, such as a stapled peptide, or a small molecule that binds a disease-related protein. The present application also relates to methods for the targeted degradation of endogenous proteins through the use of stapled peptide degron chimeras which can be utilized in the treatment of proliferative disorders or other conditions whereby elimination of a disease-causing or disease-related protein would have a therapeutic benefit. The present application also provides methods for making compounds of the application and intermediates thereof.

Abstract: A fluid tank structure is disclosed that is integrated within a bypass duct of a turbofan gas turbine engine. The fluid tank structure includes a hollow interior that is closed off when the fluid tank structure is coupled with an inner wall of the bypass duct. The inner wall forms one wall of a fluid tank volume enclosed by the fluid tank structure.

Abstract: An open-head power tong having a bifurcated frame defining a central opening and a side opening, a rotatably supported ring having a side opening and which carries releasable pipe engaging jaws that move into and out of the central opening, and a reversible hydraulic motor for driving the ring and the jaws therewith to respectively engage and rotate a pipe in a clockwise and a counterclockwise direction during respective make-up and break-out of a drill string, is provided with a pneumatically operated indexing mechanism which automatically aligns the side openings of the frame and the ring after the termination of a make-up or break-out operation such that a drill pipe, located within the central opening, is permitted to be passed laterally therethrough so as to allow the removal of the tong from the drill string.

Abstract: An open-head power tong having an access door is provided with an improved door-interlock mechanism which ensures that the door is closed before the power tong can be operated. The interlock mechanism includes a pneumatically actuated contact valve connected to a pneumatically piloted hydraulic diverter valve which is operably associated with the hydraulic motor that drives the tong. The contact valve is so positioned on the tong such that the door when moved to its closed position engages the contact valve causing the flow of pneumatic pressure to the diverter valve to position the same so as to permit hydraulic fluid to flow to the hydraulic motor for operation of the power tong. When the door is in its open position, out of engagement with the contact valve, the contact valve relieves the pressure on the diverter valve thus positioning the diverter valve to divert the flow of hydraulic fluid around the hydraulic motor whereby the operation of the power tong is stopped.