Patents by Inventor Gregory D. Vite

Gregory D. Vite has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 12,13-modified epothilone derivatives
    Patent number: 6399638
    Abstract: The present invention relates to 12,13-position modified epothilone derivatives, methods of preparation of the derivatives and intermediates therefor.
    Type: Grant
    Filed: March 29, 1999
    Date of Patent: June 4, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: Gregory D. Vite, Soong-Hoon Kim, Gerhard Höfle
  • 12, 13-cyclopropane epothilone derivatives
    Patent number: 6380395
    Abstract: The present invention relates to 12,13-position modified epothilone derivatives, methods of preparation of the derivatives and intermediates therefor.
    Type: Grant
    Filed: March 29, 1999
    Date of Patent: April 30, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: Gregory D. Vite, Soong-Hoon Kim, Gerhard Höfle
  • Preparation of epothilone intermediates
    Publication number: 20020042109
    Abstract: The present invention relates to a process for the preparation of intermediates useful in the synthesis of epothilone analogs by initially enzymatically degrading certain epothilone compounds to form ring-open structures containing a carboxyl group which is esterified, the hydroxyl groups on the moiety protected and the resulting compound oxidized by, e.g. ozone, to form a first intermediate. The first intermediate can be reacted with a triphenylphosphine adduct to yield a compound containing an ester group at position 1 which is subsequently hydrolyzed to form a second intermediate.
    Type: Application
    Filed: March 19, 2001
    Publication date: April 11, 2002
    Inventors: Gregory D. Vite, Soong-Hoon Kim, Gerhard Hofle
  • Process for the preparation of aziridinyl epothilones from oxiranyl epothilones
    Publication number: 20010031880
    Abstract: The present invention relates to a stereospecific process to produce aziridinyl epothilones from oxiranyl epothilones and the intermediates derived therein.
    Type: Application
    Filed: March 17, 2000
    Publication date: October 18, 2001
    Inventors: Robert M. Borzilleri, Soong-Hoon Kim, Alicia Regueiro-Ren, Gregory D. Vite
  • Process for the preparation of aziridinyl epothilones from oxiranyl epothilones
    Patent number: 6291684
    Abstract: The present invention relates to a stereospecific process to produce aziridinyl epothilones from oxiranyl epothilones and the intermediates derived therein.
    Type: Grant
    Filed: March 17, 2000
    Date of Patent: September 18, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: Robert M. Borzilleri, Soong-Hoon Kim, Alicia Regueiro-Ren, Gregory D. Vite
  • Method of inhibiting protease
    Patent number: 5776933
    Abstract: Novel aminediol compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds in inhibiting retroviral protease, particularly useful in the treatment and/or prevention of HIV infection (AIDS).
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: July 7, 1998
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Eric M. Gordon, Joel C. Barrish, Gregory S. Bisacchi, Chong-Qing Sun, Joseph A. Tino, Gregory D. Vite, Robert Zahler
  • Aminediol protease inhibitors
    Patent number: 5760036
    Abstract: Novel aminediol compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds in inhibiting retroviral protease, particularly useful in the treatment and/or prevention of HIV infection (AIDS).
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: June 2, 1998
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Eric M. Gordon, Joel C. Barrish, Gregory S. Bisacchi, Chong-Oing Sun, Joseph A. Tino, Gregory D. Vite, Robert Zahler
  • Aminediol protease inhibitors
    Patent number: 5559256
    Abstract: Novel aminediol compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds in inhibiting retroviral protease, particularly useful in the treatment and/or prevention of HIV infection (AIDS).
    Type: Grant
    Filed: June 25, 1993
    Date of Patent: September 24, 1996
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Eric M. Gordon, Joel C. Barrish, Gregory S. Bisacchi, Chong-Qing Sun, Joseph A. Tino, Gregory D. Vite, Robert Zahler