Abstract: The present invention provides methods for modifying chromosomal sequences. In particular, methods are provided for using RNA-guided endonucleases or modified RNA-guided endonucleases to modify targeted chromosomal sequences.

Abstract: The present invention provides methods for modifying chromosomal sequences. In particular, methods are provided for using RNA-guided endonucleases or modified RNA-guided endonucleases to modify targeted chromosomal sequences.

Abstract: Disclosed herein are representative embodiments of tools and techniques for performing contextual searches using text determined based on digital-ink data. According to one exemplary technique, digital-ink data is received at a computing device and text is determined based on the digital-ink data. Additionally, by an application of the computing device, a contextual search is performed using the text.

Abstract: Disclosed herein are methods and compositions for genome editing of a Rosa locus, using fusion proteins comprising a zinc-finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.

Abstract: A thermal energy system comprising a first thermal system in use having a cooling demand, and a heat sink connection system coupled to the first thermal system, the heat sink connection system being adapted to provide selective connection to a plurality of heat sinks for cooling the first thermal system, the heat sink connection system comprising a first heat exchanger system adapted to be coupled to a first remote heat sink containing a working fluid and a second heat exchanger system adapted to be coupled to ambient air as a second heat sink, a fluid loop interconnecting the first thermal system, the first heat exchanger system and the second heat exchanger system, at least one mechanism for selectively altering the order of the first heat exchanger system and the second heat exchanger system in relation to a fluid flow direction around the fluid loop, and a controller for actuating the at least one mechanism. An alternative embodiment has a heating demand and uses heat sources.

Abstract: The described embodiments allow for the selection of content in a touch screen display. The method includes detecting a single tap on a word of text in a text editing field in a touch screen, and responsive to the single tap selecting the word of text in whole. In another embodiment additional content can be selected. Contact with selected content displayed in a touch screen can be detected. The contact with the touch screen can be detected moving in a direction along the selected content. Additional content is selected by selecting a word of text adjacent to the selected content being contacted.

Abstract: Lighting devices are configured to communicate with one another and with external systems. Sensors located at such lighting devices communicate with the external systems and with others of the lighting devices. Lighting is controlled to maintain safety, to drive customer traffic within a retail facility, or to conserve energy. An application programming interface provides a common mechanism for control of various lighting device types.

Abstract: A firearm training tool having a shot indicating system in further in one form a trigger take-up indicating system. The trigger module is adjustable to adjust various properties of the trigger.

Abstract: A catheter used for treatment of complex vasculature, such as a bifurcated aneurysm, is provided with an inflatable balloon at a distal portion thereof. The shape, location and material of the inflatable balloon are selected such that when inflated, the balloon conforms to the shape of the complex vasculature, or at least a portion thereof, without appreciably deforming the vessel walls. In this manner, the balloon can be used to control flow in the vasculature, for example occluding a selected branch of the vasculature during introduction of material in order concentrate the material and minimize its disbursement by blood flow.

Abstract: Embodiments of the present invention provide for the control of a powered utility. A circuit board, an onboard controller located on the circuit board, and a daughterboard connector also located on the circuit board are utilized. The onboard controller is configured to provide a first level of control functionality to the system. The first level of control functionality includes the ability to transfer the powered utility between an operating state and an off state. The daughterboard connector is configured to accept a daughterboard, and that daughterboard is configured to increase the control functionality of the system above the first level of control functionality to a second level of control functionality.

Abstract: A catheter used for treatment of complex vasculature, such as a bifurcated aneurysm, is provided with an inflatable balloon at a distal portion thereof. The shape, location and material of the inflatable balloon are selected such that when inflated, the balloon conforms to the shape of the complex vasculature, or at least a portion thereof, without appreciably deforming the vessel walls. In this manner, the balloon can be used to control flow in the vasculature, for example occluding a selected branch of the vasculature during introduction of material in order concentrate the material and minimize its disbursement by blood flow.

Abstract: Systems and methods are operable to synchronize presentation between video streams and separately received audio streams. An exemplary embodiment receives a first media content stream at a media device, wherein the first media content stream comprises at least a video stream portion; receives a second media content stream at the media device, wherein the second media content stream comprises at least an audio stream portion; delays the audio stream portion of the second media content stream by a duration corresponding to at least one synchronization time delay; communicates the video stream portion of the first media content stream to a visual display device; and communicates the delayed audio stream portion of the second media content stream to an audio presentation device, wherein a visual scene of the video stream portion of the first media content stream is substantially synchronized with sounds of the audio stream portion of the second media content stream.

Abstract: A system for peer-to-portal broadcasting, including a portal web server serving a portal web page that includes source code received from and generated by a broadcast server, to a web browser, in response to a request received from the web browser, a broadcast server, including a source code generator for generating the source code that is included in the portal web page, in response to a request received from the portal web server, a web client computer for requesting the portal web page from the portal web server and for executing the source code included in the portal web page, and a publisher computer that enables a publisher to broadcast media files from the publisher computer to the web client computer via the broadcast server, in response to the web client computer executing the source code included in the portal web page.

Abstract: A trapping device for trapping non-dispersing cloths in a toilet bowl is disclosed. The trapping device comprises a strap and a plurality of hooks. The trapping device may be installed in a trapway of the toilet bowl. The strap has a first end, a second end, and a middle portion, wherein the first end includes a first tab extending perpendicular to the strap and the second end includes a second tab extending perpendicular to the strap, and the middle portion is rounded. The plurality of hooks extend from an inner wall of the strap. The strap is made of a strap material that is resilient to bend and springs back to its previous shape, such as a stainless steel or a high density polyethylene.

Abstract: Embodiments of the present invention provide for the rapid reignition of a high intensity discharge lamp. In one embodiment of the invention, an apparatus for a fast reigntion of a high intensity discharge lamp is disclosed. The apparatus is comprised of a ballast operatively coupled to the lamp that is configured to receive power from a power supply. The apparatus is also comprised of a timer circuit that enters a timing phase and produces a quantum of timing information when the lamp ceases receiving power from the power supply. This timer circuit does not require external power during the timing phase. The apparatus is additionally comprised of a control circuit that receives the timing information and permits the ballast to reignite the lamp based on the information.

Abstract: Systems and methods are operable to synchronize presentation between video streams and separately received audio streams. An exemplary embodiment receives a first media content stream at a media device, wherein the first media content stream comprises at least a video stream portion; receives a second media content stream at the media device, wherein the second media content stream comprises at least an audio stream portion; delays the audio stream portion of the second media content stream by a duration corresponding to at least one synchronization time delay; communicates the video stream portion of the first media content stream to a visual display device; and communicates the delayed audio stream portion of the second media content stream to an audio presentation device, wherein a visual scene of the video stream portion of the first media content stream is substantially synchronized with sounds of the audio stream portion of the second media content stream.

Abstract: A catheter used for treatment of complex vasculature, such as a bifurcated aneurysm, is provided with an inflatable balloon at a distal portion thereof. The shape, location and material of the inflatable balloon are selected such that when inflated, the balloon conforms to the shape of the complex vasculature, or at least a portion thereof, without appreciably deforming the vessel walls. In this manner, the balloon can be used to control flow in the vasculature, for example occluding a selected branch of the vasculature during introduction of material in order concentrate the material and minimize its disbursement by blood flow.

Abstract: Embodiments of the present invention provide for the control of a powered utility. A circuit board, an onboard controller located on the circuit board, and a daughterboard connector also located on the circuit board are utilized. The onboard controller is configured to provide a first level of control functionality to the system. The first level of control functionality includes the ability to transfer the powered utility between an operating state and an off state. The daughterboard connector is configured to accept a daughterboard, and that daughterboard is configured to increase the control functionality of the system above the first level of control functionality to a second level of control functionality.

Abstract: Lighting devices are configured to communicate with one another and with external systems. Sensors located at such lighting devices communicate with the external systems and with others of the lighting devices. Lighting is controlled to maintain safety, to drive customer traffic within a retail facility, or to conserve energy. An application programming interface provides a common mechanism for control of various lighting device types.

Abstract: Disclosed herein are methods and compositions for genome editing of a Rosa locus, using fusion proteins comprising a zinc-finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.