Patents by Inventor Gregory Dudley

Gregory Dudley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SELECTIVE PHOSPHATASE INHIBITORS BASED ON ILLUDALIC ACID
    Publication number: 20230265065
    Abstract: The present disclosure provides novel selective phosphatase inhibitor compounds based on illudalic acid. The present disclosure provides a streamlined method of synthesizing illudalic acid and a method for synthesizing phosphatase inhibitor compounds. The method of this invention provides convergent benzannulation of ?-keto amides and esters, followed by a one-pot reduction/hydrolysis sequence. The concise synthetic approach provided by this invention enables rapid assembly of illudalog compounds of this invention that are potent protein tyrosine phosphatase receptor-type D (PTPRD) inhibitors.
    Type: Application
    Filed: July 29, 2021
    Publication date: August 24, 2023
    Inventors: Gregory Dudley, Paratchata Batsomboon, Robert Gaston, Harvey Fulo
  • Compounds and methods of arylmethylation (benzylation) as protection for alcohol groups during chemical synthesis
    Patent number: 8580992
    Abstract: A process for benzylating an alcohol includes mixing 2-benzyloxy-1-methylpyridinium triflate in an aromatic hydrocarbon solvent having a predetermined boiling point; adding an acid scavenger to the mixture; combining the alcohol to be benzylated with the mixture; reacting the alcohol with the 2-benzyloxy-1-methylpyridinium triflate by heating above ambient temperature to generate the benzylated alcohol; and separating the benzylated alcohol from the mixture.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: November 12, 2013
    Assignee: The Florida State University Research Foundation, Inc.
    Inventor: Gregory Dudley
  • Compounds and methods of arylmethylation (benzylation) as protection for alcohol groups during chemical synthesis
    Patent number: 8334414
    Abstract: A process for benzylating an alcohol includes mixing 2-benzyloxy-1-methylpyridinium triflate in an aromatic hydrocarbon solvent having a predetermined boiling point; adding an acid scavenger to the mixture; combining the alcohol to be benzylated with the mixture; reacting the alcohol with the 2-benzyloxy-1-methylpyridinium triflate by heating above ambient temperature to generate the benzylated alcohol; and separating the benzylated alcohol from the mixture.
    Type: Grant
    Filed: June 23, 2010
    Date of Patent: December 18, 2012
    Assignee: Florida State University Research Foundation, Inc.
    Inventor: Gregory Dudley
  • Compounds and methods of arylmethylation (benzylation) as protection for alcohol groups during chemical synthesis
    Patent number: 8008531
    Abstract: A process for benzylating an alcohol includes mixing 2-benzyloxy-1-methylpyridinium triflate in an aromatic hydrocarbon solvent having a predetermined boiling point; adding an acid scavenger to the mixture; combining the alcohol to be benzylated with the mixture; reacting the alcohol with the 2-benzyloxy-1-methylpyridinium triflate by heating above ambient temperature to generate the benzylated alcohol; and separating the benzylated alcohol from the mixture.
    Type: Grant
    Filed: June 23, 2010
    Date of Patent: August 30, 2011
    Assignee: The Florida State University Research Foundation, Inc.
    Inventor: Gregory Dudley
  • Compounds and methods of arylmethylation (benzylation) as protection for alcohol groups during chemical synthesis
    Patent number: 7915437
    Abstract: A process for benzylating an alcohol includes mixing 2-benzyloxy-1-methylpyridinium triflate in an aromatic hydrocarbon solvent having a predetermined boiling point; adding an acid scavenger to the mixture; combining the alcohol to be benzylated with the mixture; reacting the alcohol with the 2-benzyloxy-1-methylpyridinium triflate by heating above ambient temperature to generate the benzylated alcohol; and separating the benzylated alcohol from the mixture.
    Type: Grant
    Filed: June 23, 2010
    Date of Patent: March 29, 2011
    Assignee: Florida State University Research Foundation, Inc.
    Inventor: Gregory Dudley
  • Compounds and Methods of Arylmethylation (Benzylation) As Protection For Alcohol Groups During Chemical Synthesis
    Publication number: 20100324323
    Abstract: A process for benzylating an alcohol includes mixing 2-benzyloxy-1-methylpyridinium triflate in an aromatic hydrocarbon solvent having a predetermined boiling point; adding an acid scavenger to the mixture; combining the alcohol to be benzylated with the mixture; reacting the alcohol with the 2-benzyloxy-1-methylpyridinium triflate by heating above ambient temperature to generate the benzylated alcohol; and separating the benzylated alcohol from the mixture.
    Type: Application
    Filed: June 23, 2010
    Publication date: December 23, 2010
    Inventor: Gregory Dudley
  • Compounds and Methods of Arylmethylation (Benzylation) As Protection For Alcohol Groups During Chemical Synthesis
    Publication number: 20100324324
    Abstract: A process for benzylating an alcohol includes mixing 2-benzyloxy-1-methylpyridinium triflate in an aromatic hydrocarbon solvent having a predetermined boiling point; adding an acid scavenger to the mixture; combining the alcohol to be benzylated with the mixture; reacting the alcohol with the 2-benzyloxy-1-methylpyridinium triflate by heating above ambient temperature to generate the benzylated alcohol; and separating the benzylated alcohol from the mixture.
    Type: Application
    Filed: June 23, 2010
    Publication date: December 23, 2010
    Inventor: Gregory Dudley
  • Compounds and Methods of Arylmethylation (Benzylation) As Protection For Alcohol Groups During Chemical Synthesis
    Publication number: 20100256383
    Abstract: A process for benzylating an alcohol includes mixing 2-benzyloxy-1-methylpyridinium triflate in an aromatic hydrocarbon solvent having a predetermined boiling point; adding an acid scavenger to the mixture; combining the alcohol to be benzylated with the mixture; reacting the alcohol with the 2-benzyloxy-1-methylpyridinium triflate by heating above ambient temperature to generate the benzylated alcohol; and separating the benzylated alcohol from the mixture.
    Type: Application
    Filed: June 23, 2010
    Publication date: October 7, 2010
    Inventor: Gregory Dudley
  • Compounds and methods of arylmethylation (benzylation) as protection for alcohol groups during chemical synthesis
    Patent number: 7754909
    Abstract: A process for benzylating an alcohol includes mixing 2-benzyloxy-1-methylpyridinium triflate in an aromatic hydrocarbon solvent having a predetermined boiling point; adding an acid scavenger to the mixture; combining the alcohol to be benzylated with the mixture; reacting the alcohol with the 2-benzyloxy-1-methylpyridinium triflate by heating above ambient temperature to generate the benzylated alcohol; and separating the benzylated alcohol from the mixture.
    Type: Grant
    Filed: April 6, 2006
    Date of Patent: July 13, 2010
    Assignee: The Florida State University Research Foundation, Inc.
    Inventor: Gregory Dudley