Patents by Inventor Gregory F. Miknis

Gregory F. Miknis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phospholipid compositions
    Patent number: 10493086
    Abstract: Compositions involving a modified egg yolk extract for use as an effective anti-cancer agent are described. The modified egg yolk extract involves specific fractions of phosphatidylcholines and sphingomyelins modified and produced from a chemical synthesis applied to the extract that produce a beneficial effect on the inhibition of cancerous cell growth. Methods of administering these compositions are also described.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: December 3, 2019
    Assignee: MACHAVERT PHARMACEUTICALS LLC
    Inventors: Jakub Staszak-Jirkovsky, Lukas Kobr, Gregory F. Miknis, Colleen Hudson, Luca Monfregola, Pavel Jirkovsky, Zbon{hacek over (c)}áková Milada, Jason Duex, Pitchaimani Kandasamy
  • PHOSPHOLIPID COMPOSITIONS
    Publication number: 20180028545
    Abstract: Compositions involving a modified egg yolk extract for use as an effective anti-cancer agent are described. The modified egg yolk extract involves specific fractions of phosphatidylcholines and sphingomyelins modified and produced from a chemical synthesis applied to the extract that produce a beneficial effect on the inhibition of cancerous cell growth. Methods of administering these compositions are also described.
    Type: Application
    Filed: October 6, 2017
    Publication date: February 1, 2018
    Inventors: Jakub STASZAK-JIRKOVSKY, Lukas KOBR, Gregory F. MIKNIS, Colleen HUDSON, Luca MONFREGOLA,, Pavel JIRKOVSKY, Zboncáková MILADA, Jason DUEX, Pitchaimani KANDASAMY
  • PHOSPHOLIPID COMPOSITIONS
    Publication number: 20180000850
    Abstract: Compositions involving a modified egg yolk extract for use as an effective anti-cancer agent are described. The modified egg yolk extract involves specific fractions of phosphatidylcholines and sphingomyelins modified and produced from a chemical synthesis applied to the extract that produce a beneficial effect on the inhibition of cancerous cell growth. Methods of administering these compositions are also described.
    Type: Application
    Filed: June 29, 2017
    Publication date: January 4, 2018
    Inventors: Jakub STASZAK-JIRKOVSKY, Lukas KOBR, Gregory F. MIKNIS, Colleen HUDSON, Luca MONFREGOLA,, Pavel JIRKOVSKY, Zboncåkovå MILADA, Jason DUEX, Pitchaimani KANDASAMY
  • Substituted pyrazolo[1,5-a]pyrimidine compounds as mTOR inhibitors
    Patent number: 8865726
    Abstract: Compounds of Formula I: and salts thereof in which R1, R2, R2a, R3, n, X and ring B have the meanings given in the specification, are inhibitors of mTOR and are useful in the treatment of diseases which are sensitive to inhibition of mTOR, such as cancers.
    Type: Grant
    Filed: September 3, 2010
    Date of Patent: October 21, 2014
    Assignee: Array BioPharma Inc.
    Inventors: Steven W. Andrews, Kevin Ronald Condroski, Lisa A. De Meese, Jay Bradford Fell, John P. Fischer, John A. Josey, Kevin Koch, Yvan Le Huerou, Gregory F. Miknis, Martha E. Rodriguez, George T. Topalov, Eli M. Wallace, Rui Xu
  • SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS
    Publication number: 20120178715
    Abstract: Compounds of Formula I: and salts thereof in which R1, R2, R2a, R3, n, X and ring B have the meanings given in the specification, are inhibitors of mTOR and are useful in the treatment of diseases which are sensitive to inhibition of mTOR, such as cancers.
    Type: Application
    Filed: September 3, 2010
    Publication date: July 12, 2012
    Applicant: ARRAY BIOPHARMA INC.
    Inventors: Steven W. Andrews, Kevin Ronald Condroski, Lisa A. De Meese, Jay Bradford Fell, John P. Fischer, John A. Josey, Kevin Koch, Yvan Le Huerou, Gregory F. Miknis, Martha E. Rodriguez, George T. Topalov, Eli M. Wallace, Rui Xu
  • INHIBITORS OF PHOSPHATASES
    Publication number: 20090060968
    Abstract: The present invention relates to compounds that inhibit phosphatases, compositions thereof, and methods of using those compounds and compositions for treating diseases.
    Type: Application
    Filed: September 12, 2008
    Publication date: March 5, 2009
    Inventors: Jeffrey O. Saunders, Gregory F. Miknis, Alexandre J. Buckmelter, Kevin W. Hunt, James F. Blake, Guy P.A. Vigers, Xicheng Sun
  • Inhibitors of phosphatases
    Patent number: 7439249
    Abstract: The present invention relates to compounds that inhibit phosphatases, compositions thereof, and methods of using those compounds and compositions for treating diseases.
    Type: Grant
    Filed: December 31, 2003
    Date of Patent: October 21, 2008
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jeffrey O. Saunders, Gregory F. Miknis, Alexandre J. Buckmelter, Kevin W. Hunt, James F. Blake, Guy P. A. Vigers, Xicheng Sun
  • Sulfhydantoins as phosphate isosteres
    Patent number: 7432292
    Abstract: The present invention relates to novel phosphate isosteres. The invention relates to compounds having a sulfhydantoin or a reverse sulfhydantoin moiety, uses thereof, and related methods. The present invention relates to compounds of formula I or II: or pharmaceutically acceptable salts thereof; wherein Q, T, m, and X are as described herein. These compounds are inhibitors of phosphatases, particularly inhibitors of SHP-2. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing these compounds and compositions in the treatment of various phosphatase-mediated diseases.
    Type: Grant
    Filed: December 30, 2003
    Date of Patent: October 7, 2008
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jeffrey O. Saunders, Gregory F. Miknis, James F. Blake
  • Inhibitors of phosphatases
    Publication number: 20040186116
    Abstract: The present invention relates to compounds that inhibit phosphatases, compositions thereof, and methods of using those compounds and compositions for treating diseases.
    Type: Application
    Filed: December 31, 2003
    Publication date: September 23, 2004
    Inventors: Jeffrey O. Saunders, Gregory F. Miknis, Alexandre J. Buckmelter, Kevin W. Hunt, James F. Blake, Guy P.A. Vigers, Xicheng Sun
  • Sulfhydantoins as phosphate isosteres
    Publication number: 20040167187
    Abstract: The present invention relates to novel phosphate isosteres. The invention relates to compounds having a sulfhydantoin or a reverse sulfhydantoin moiety, uses thereof, and related methods.
    Type: Application
    Filed: December 30, 2003
    Publication date: August 26, 2004
    Inventors: Jeffrey O. Saunders, Gregory F. Miknis, James F. Blake