Abstract: The current disclosure provide a novel human calcium sensing receptor named CaR2 and the nucleotide sequence that encodes the receptor. The disclosure further provides antibodies specific for CaR2. Also disclosed are methods of identifying modulators of the receptor and methods of using the identified modulators to treat calcium receptor mediated conditions.

Abstract: A method for determining a threshold value of a parameter used to determine whether an individual has Attention Deficit Hyperactivity Disorder (ADHD) comprising: providing a group of individuals a segment of which is known to have ADHD and a segment of which is known to be normal and not have ADHD; testing each individual in the group by sampling the peripheral skin temperature of the individual during a pre-determined time interval when the subject is in an inactive state to provide sampled peripheral skin temperature data, and analyzing the sampled peripheral skin data to produce a parameter value for that individual; and processing the individual parameter values for all of the members of the group to determine a threshold parameter value which is acceptable for determining whether or not an individual has ADHD when tested by said testing procedure.