Patents by Inventor Gregory G. Kubiak

Gregory G. Kubiak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • STABLE NON-HYGROSCOPIC CRYSTALLINE FORM OF N-[N-[N-(4-(PIPERIDIN-4-YL)BUTANOYL)-N-ETHYLGLYCYL]ASPARTYL]-L-&bgr;-CYCLOHEXYL ALANINE AMIDE, INTERMEDIATES THEREOF, AND PREPARATION THEREOF AND OF ANTITHROMBOTIC AZACYCLOALKYLALKANOYL PEPTIDES AND PSEUDOPEPTIDES
    Patent number: 6753409
    Abstract: The invention is directed to a non-hygroscopic stable crystalline form of the antithrombotic compound N-[N-[N-(4-piperdin-4-yl)butanoyl)-N-ethylglycyl]-(L)-aspartyl]-(L)-&bgr;-cyclohexyl-alanine amide, to processes for preparing said stable crystalline form, to a pharmaceutical composition thereof, and intermediates thereof, and the invention is directed also to processes for preparing a compound of the formula wherein: A, B, Z, E1, E2, G, R, m, n, and p are as defined herein.
    Type: Grant
    Filed: August 15, 2000
    Date of Patent: June 22, 2004
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Zofia J. Chrzan, James J. Mencel, David Toledo-Velasquez, Vincent Windisch, Rick G. Woodward, Diane C. Salazar, Narasimha M. Vemuri, Anthony J. Gardetto, Matthew R. Powers, Gregory G. Kubiak, Robert C. Liu, Benoit J. Vanasse, James P. Sherbine, Walter Rodriguez, Adam W. Sledeski
  • Novel processes for the preparation of adenosine compounds and intermediates thereto
    Publication number: 20030069423
    Abstract: Novel processes for the preparation of adenosine compounds and intermediates thereto. The adenosine compounds prepared by the present processes may be useful as cardiovascular agents, more particularly as antihypertensive and anti-ischemic agents, as cardioprotective agents which ameliorate ischemic injury or myocardial infarct size consequent to myocardial ischemia, and as an antilipolytic agents which reduce plasma lipid levels, serum triglyceride levels, and plasma cholesterol levels. The present processes may offer improved yields, purity, ease of preparation and/or isolation of intermediates and final product, and more industrially useful reaction conditions and workability.
    Type: Application
    Filed: May 10, 2002
    Publication date: April 10, 2003
    Inventors: Timothy A. Ayers, Geoffrey A. D'Netto, Gregory G. Kubiak, James J. Mencel, Michael K. O'Brien, Matthew R. Powers, John J. Shay, Adam W. Sledeski, David S. Teager, Benoit Vanasse
  • Process for preparing N6-substituted adenosine derivatives
    Patent number: 6429315
    Abstract: This invention is directed to a process for preparing N6-substituted adenosine derivatives, to intermediates useful therefor and to methods of preparing these intermediates.
    Type: Grant
    Filed: January 21, 2000
    Date of Patent: August 6, 2002
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Adam W. Sledeski, Luc Grondard, Matthew R. Powers, Tory H. Powner, Michael K. O'Brien, Ching T. Tsuei, Patrick Leon, Gregory G. Kubiak, Laurence Pailleres-Hubert, Benoit Viguier
  • Stable non-hygroscopic crystalline form of N-[N-[N-4-(piperidin-4-yl)butanoyl)-N-ethylglycyl] aspartyl]-L-.beta.-cyclohexyl alanine amide
    Patent number: 6153588
    Abstract: The invention is directed to a non-hygroscopic stable crystalline form of the antithrombotic compound N-[N-[N-(4-piperdin-4-yl)butanoyl)-N-ethylglycyl]-(L)-aspartyl]-(L)-.beta. -cyclohexyl-alanine amide, to processes for preparing said stable crystalline form, to a pharmaceutical composition thereof, and intermediates thereof, and the invention is directed also to processes for preparing a compound of the formula ##STR1## wherein: A, B, Z, E.sup.1, E.sup.2, G, R, m, n, and p are as defined herein.
    Type: Grant
    Filed: February 18, 1999
    Date of Patent: November 28, 2000
    Assignee: Aventis Pharmaceuticals Products Inc.
    Inventors: Zofia J. Chrzan, James J. Mencel, David Toledo-Velasquez, Vincent Windisch, Rick G. Woodward, Diane C. Salazar, deceased, Narasimha M. Vemuri, Anthony J. Gardetto, Matthew R. Powers, Gregory G. Kubiak, Robert C. Liu, Benoit J. Vanasse, James P. Sherbine, Walter Rodriguez, Adam W. Sledeski