Abstract: The present invention relates to metformin for use in treating a patient, wherein the patient exhibits an increased level of GDF15 in response to metformin treatment; to methods of identifying a patient who will benefit or who will not benefit from metformin treatment; methods of treating a patient at risk of developing or suffering from a disease or disorder comprising administering therapeutically effective amount of metformin; methods of adapting the dosage of metformin; the usage of GDF15 as biomarker for identifying a patient who will benefit or who will not benefit from metformin treatment, kits for use in identifying a patient who will benefit from metformin treatment and the use of the kits, as well as methods of treating a patient or who will not benefit from metformin treatment.

Abstract: A modular surfacing system has edge pieces with skirts attached using a break away adhesive material allowing separation of the pieces without damage. The edge rail pieces may be used alone or with the skirt piece attached at any of a variety of overhanging heights to cover different substrate edge thicknesses. Skirts may be interchanged. The modular surfacing pieces may be solid seamless cut natural stone modular pieces, laminated natural stone modular pieces, composite material or synthetic material shaped into modular pieces. The pieces are cut into any desired sizes with wide edging of any desirable thickness and solid piece corners as well as mating modular surface tiles and mating modular backsplash tiles.