Patents by Inventor Gregory GOSCH

Gregory GOSCH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPETITIVE PROBES FOR ENGINEERING SIGNAL GENERATION
    Publication number: 20230357826
    Abstract: A method of identifying a first target nucleic acid comprising, providing a sample comprising the first target nucleic acid, providing a first set of paired oligonucleotides with complementarity to the first target nucleic acid, the first set of paired oligonucleotides comprising a first ratio of (a) first competitive oligonucleotides to (b) first signal oligonucleotides comprising a signal tag, wherein the competitive oligonucleotides compete with the signal oligonucleotides for binding to the first target nucleic acid, amplifying the first target nucleic acid with the polymerase chain reaction, thereby degrading the first signal oligonucleotide and permitting generation of a first signal, generating the first signal, measuring intensity of the first signal, and correlating the intensity of the first signal to the first ratio, thereby identifying the first target nucleic acid.
    Type: Application
    Filed: November 4, 2022
    Publication date: November 9, 2023
    Inventors: Lucien A.E. JACKY, Aditya RAJAGOPAL, Karen L. MENGE, Gregory GOSCH
  • COMPETITIVE PROBES FOR ENGINEERING SIGNAL GENERATION
    Publication number: 20220002788
    Abstract: A method of identifying a first target nucleic acid comprising, providing a sample comprising the first target nucleic acid, providing a first set of paired oligonucleotides with complementarity to the first target nucleic acid, the first set of paired oligonucleotides comprising a first ratio of (a) first competitive oligonucleotides to (b) first signal oligonucleotides comprising a signal tag, wherein the competitive oligonucleotides compete with the signal oligonucleotides for binding to the first target nucleic acid, amplifying the first target nucleic acid with the polymerase chain reaction, thereby degrading the first signal oligonucleotide and permitting generation of a first signal, generating the first signal, measuring intensity of the first signal, and correlating the intensity of the first signal to the first ratio, thereby identifying the first target nucleic acid.
    Type: Application
    Filed: September 21, 2021
    Publication date: January 6, 2022
    Inventors: Lucien A.E. JACKY, Aditya RAJAGOPAL, Karen L. MENGE, Gregory GOSCH
  • COMPETITIVE PROBES FOR ENGINEERING SIGNAL GENERATION
    Publication number: 20200087714
    Abstract: A method of identifying a first target nucleic acid comprising, providing a sample comprising the first target nucleic acid, providing a first set of paired oligonucleotides with complementarity to the first target nucleic acid, the first set of paired oligonucleotides comprising a first ratio of (a) first competitive oligonucleotides to (b) first signal oligonucleotides comprising a signal tag, wherein the competitive oligonucleotides compete with the signal oligonucleotides for binding to the first target nucleic acid, amplifying the first target nucleic acid with the polymerase chain reaction, thereby degrading the first signal oligonucleotide and permitting generation of a first signal, generating the first signal, measuring intensity of the first signal, and correlating the intensity of the first signal to the first ratio, thereby identifying the first target nucleic acid.
    Type: Application
    Filed: November 21, 2019
    Publication date: March 19, 2020
    Inventors: Lucien A.E. JACKY, Aditya RAJAGOPAL, Karen L. MENGE, Gregory GOSCH
  • COMPETITIVE PROBES FOR ENGINEERING SIGNAL GENERATION
    Publication number: 20190233882
    Abstract: A method of identifying a first target nucleic acid comprising, providing a sample comprising the first target nucleic acid, providing a first set of paired oligonucleotides with complementarity to the first target nucleic acid, the first set of paired oligonucleotides comprising a first ratio of (a) first competitive oligonucleotides to (b) first signal oligonucleotides comprising a signal tag, wherein the competitive oligonucleotides compete with the signal oligonucleotides for binding to the first target nucleic acid, amplifying the first target nucleic acid with the polymerase chain reaction, thereby degrading the first signal oligonucleotide and permitting generation of a first signal, generating the first signal, measuring intensity of the first signal, and correlating the intensity of the first signal to the first ratio, thereby identifying the first target nucleic acid.
    Type: Application
    Filed: April 5, 2019
    Publication date: August 1, 2019
    Inventors: Lucien A.E. JACKY, Aditya RAJAGOPAL, Karen L. MENGE, Gregory GOSCH
  • Competitive probes for engineering signal generation
    Patent number: 10301668
    Abstract: A method of identifying a first target nucleic acid comprising, providing a sample comprising the first target nucleic acid, providing a first set of paired oligonucleotides with complementarity to the first target nucleic acid, the first set of paired oligonucleotides comprising a first ratio of (a) first competitive oligonucleotides to (b) first signal oligonucleotides comprising a signal tag, wherein the competitive oligonucleotides compete with the signal oligonucleotides for binding to the first target nucleic acid, amplifying the first target nucleic acid with the polymerase chain reaction, thereby degrading the first signal oligonucleotide and permitting generation of a first signal, generating the first signal, measuring intensity of the first signal, and correlating the intensity of the first signal to the first ratio, thereby identifying the first target nucleic acid.
    Type: Grant
    Filed: August 15, 2017
    Date of Patent: May 28, 2019
    Assignee: CHROMACODE, INC.
    Inventors: Lucien A. E. Jacky, Aditya Rajagopal, Karen L. Menge, Gregory Gosch
  • COMPETITIVE PROBES FOR ENGINEERING SIGNAL GENERATION
    Publication number: 20180057864
    Abstract: A method of identifying a first target nucleic acid comprising, providing a sample comprising the first target nucleic acid, providing a first set of paired oligonucleotides with complementarity to the first target nucleic acid, the first set of paired oligonucleotides comprising a first ratio of (a) first competitive oligonucleotides to (b) first signal oligonucleotides comprising a signal tag, wherein the competitive oligonucleotides compete with the signal oligonucleotides for binding to the first target nucleic acid, amplifying the first target nucleic acid with the polymerase chain reaction, thereby degrading the first signal oligonucleotide and permitting generation of a first signal, generating the first signal, measuring intensity of the first signal, and correlating the intensity of the first signal to the first ratio, thereby identifying the first target nucleic acid.
    Type: Application
    Filed: August 15, 2017
    Publication date: March 1, 2018
    Inventors: Lucien A.E. JACKY, Aditya RAJAGOPAL, Karen L. MENGE, Gregory GOSCH